Publications
  • Clapes, P.; Joglar, J.; Gutierrez, M., Carbon-carbon bond-forming enzymes for the synthesis of non-natural amino acids. Methods in Molecular Biology. Springer Science+Business Media, LLC 794 73-85, 2012
    DOI: 10.1007/978-1-61779-331-8_5

  • Clapés, P.; Garrabou, X., Current Trends in Asymmetric Synthesis with Aldolases. Adv. Synth. Catal. 353 (13) 2263-2283, 2011
    DOI: 10.1002/chin.201202243

  • Garrabou, X.; Calveras, J.; Joglar, J.; Parella, T.; Bujons, J.; Clapes, P., Highly Efficient Aldol additions of DHA and DHAP to N-Cbz-Amino aldehydes Catalyzed by L-Rhamnulose-1-Phosphate and L-Fuculose-1-Phosphate Aldolases in Aqueous Borate Buffer. Org. Biomol. Chem. 9 (24) 8430 - 8436, 2011
    DOI: 10.1039/C1OB06263H Further information: http://pubs.rsc.org/en/content/articlelanding/2011/ob/c1ob06263h

  • Clapés P.; Fessner, W.-D., Enzymatic direct aldol additions. Science of Synthesis. Stereoselective Synthesis 2. Stereoselective Reactions of Carbonyl and Imino Groups, Molander, G. A., Ed. Georg Thieme Verlag KG: Suttgart (Germany) Vol. 2 677-734, 2011

  • Gutierrez, M.; Parella, T.; Joglar, J.; Bujons, J.; Clapés P., Structure-guided redesign of D-fructose-6-phosphate aldolase from E. coli: remarkable activity and selectivity towards acceptor substrates by two-point mutation. Chem. Commun. 47 (20) 5762-5764, 2011
    DOI: 10.1039/C1CC11069A

  • Gómez, L.; Molinar-Toribio, E.; Calvo-Torras, M. ; Adelantado, C.; Juan, M. E.; Planas, J. M.; Cañas X.; Lozano, C.; Pumarola, S.; Clapés P.; Torres, J. L., D-Fagomine lowers postprandial blood glucose and modulates bacterial adhesion. Br. J. Nutr. FirstView 1-8, 2011
    DOI: 10.1017/S0007114511005009

  • Garrabou, X.; Joglar, J.; Parella, T.; Bujons, J.; Clapés, P., Redesign of the Phosphate Binding Site of L-Rhamnulose-1-Phosphate Aldolase towards a Dihydroxyacetone Dependent Aldolase. Adv. Synth. Catal. 353, (1) 89-99, 2011
    DOI: 10.1002/adsc.201000719

  • Clapes, S. P.; Joglar, T. J.; Concia, A. L.; Castillo, E. J. A.; Lozano, P. C., Chemoenzymatic method for the synthesis of 1-deoxy-D-xylulose. WO2010086482A1, 2010
    Further information: http://handle.digital.csic.es/bitstream/10261/32702/1/WO2010086482A1.pdf

  • Castillo, J. A.; Guérard-Hélaine, C.; Gutiérrez, M.; Garrabou, X.; Sancelme, M.; Schürmann, M.; Inoue, T.; Hélaine, V.; Charmantray, F.; Gefflaut, T.; Hecquet, L.; Joglar, J.; Clapés, P.; Sprenger, G. A.; Lemaire, M., A Mutant D-Fructose-6-Phosphate Aldolase (Ala129Ser) with Improved Affinity towards Dihydroxyacetone for the Synthesis of Polyhydroxylated Compounds. Adv. Synth. Catal. 352, (6) 1039-1046, 2010
    DOI: 10.1002/chin.201035036

  • Garrabou, X.; Gomez, L.; Joglar, J.; Gil, S.; Parella, T.; Bujons, J.; Clapés, P., Structure-guided minimalist redesign of L-fuculose-1-phosphate aldolase active site. Expedient synthesis of novel polyhydroxylated pyrrolizidines and their inhibitory properties against glycosidases and intestinal disaccharidases. Chem. Eur. J. 16 10691-10706, 2010
    DOI: 10.1002/chem.201000714

  • Schneider, S.; Gutiérrez, M.; Sandalova, T.; Schneider, G.; Clapés, P.; Sprenger, G. A.; Samland, A. K., Redesigning the Active Site of Transaldolase TalB from Escherichia coli: New Variants with Improved Affinity towards Nonphosphorylated Substrates. Chembiochem 11 (5) 681-690, 2010
    DOI: 10.1002/cbic.200900720

  • Clapes, P.; Fessner, W.-D.; Sprenger, G. A.; Samland, A. K., Recent progress in stereoselective synthesis with aldolases. Curr. Opin. Chem. Biol. 14, (2) 154-167, 2010
    DOI: 10.1016/j.cbpa.2009.11.029

  • Padró, M.; Castillo, J.; Gómez, L.; Joglar, J.; Clapés, P.; de Bolós C., Cytotoxicity and enzymatic activity inhibition in cell lines treated with novel iminosugar derivatives. Glycoconjugate J. 27 (2) 277-285, 2010
    DOI: 10.1007/s10719-009-9276-3 Further information: http://www.springerlink.com/content/5u526h340170722w/fulltext.pdf