{"id":11271,"date":"2026-05-28T16:42:45","date_gmt":"2026-05-28T14:42:45","guid":{"rendered":"https:\/\/www.iqac.csic.es\/grupos-investigacion\/nanomedicina-per-a-aplicacions-terapeutiques\/"},"modified":"2026-05-28T16:42:45","modified_gmt":"2026-05-28T14:42:45","slug":"nanomedicina-per-a-aplicacions-terapeutiques","status":"publish","type":"grupos-investigacion","link":"https:\/\/www.iqac.csic.es\/ca\/grupos-investigacion\/nanomedicina-per-a-aplicacions-terapeutiques\/","title":{"rendered":"Nanomedicina per a aplicacions terap\u00e8utiques"},"content":{"rendered":"<p>El grup de Nanomedicina per a Aplicacions Terap\u00e8utiques desenvolupa estrat\u00e8gies terap\u00e8utiques avan\u00e7ades basades en el disseny de nano- i biotransportadors intel\u00b7ligents per a l&#8217;administraci\u00f3 dirigida de f\u00e0rmacs, \u00e0cids nucleics i prote\u00efnes. Aquests nanotransportadors estan dissenyats per millorar l&#8217;estabilitat, l&#8217;especificitat i el lliurament intracel\u00b7lular dels agents terap\u00e8utics, augmentant-ne l&#8217;efic\u00e0cia i minimitzant els efectes secundaris. <\/p>\n<p>Treballem amb diversos sistemes, incloent-hi micel\u00b7les polim\u00e8riques, liposomes, nanopart\u00edcules d&#8217;\u00f2xid de ferro i fotot\u00e8rmiques, ves\u00edcules extracel\u00b7lulars (EVs) i sistemes h\u00edbrids com combinacions EV\u2013liposoma. Aquestes tecnologies s&#8217;apliquen a necessitats m\u00e8diques no cobertes en c\u00e0ncer, malalties d&#8217;emmagatzematge lisos\u00f2mic, ferides cr\u00f2niques i malalties relacionades amb el sistema immunitari. <\/p>\n<p>Un eix clau de la nostra recerca \u00e9s la ter\u00e0pia del c\u00e0ncer. Desenvolupem micel\u00b7les polim\u00e8riques carregades amb agents quimioterap\u00e8utics i les combinem amb estrat\u00e8gies fotot\u00e8rmiques per millorar la selectivitat tumoral, optimitzar el lliurament citos\u00f2lic i estimular respostes immunit\u00e0ries. Aix\u00f2 inclou nanotractaments activats per llum dissenyats per induir mort cel\u00b7lular immunog\u00e8nica i donar suport al desenvolupament de vacunes contra el c\u00e0ncer de c\u00e8l\u00b7lules completes.  <\/p>\n<p>Integrem intel\u00b7lig\u00e8ncia artificial i aprenentatge autom\u00e0tic per accelerar el disseny i l&#8217;optimitzaci\u00f3 de nanomedicines, i treballem amb models in vitro i in vivo avan\u00e7ats per avaluar l&#8217;efic\u00e0cia terap\u00e8utica, la seguretat, la biodistribuci\u00f3 i la modulaci\u00f3 immune, connectant la recerca b\u00e0sica amb l&#8217;aplicaci\u00f3 translacional.<\/p>\n<h3>L\u00ednies principals de recerca<\/h3>\n<ul>\n<li><strong>Nanotransportadors intel\u00b7ligents per a administraci\u00f3 terap\u00e8utica:<\/strong> Disseny i desenvolupament de nanopart\u00edcules polim\u00e8riques i micel\u00b7les, liposomes, nanopart\u00edcules magn\u00e8tiques i fotot\u00e8rmiques, ves\u00edcules extracel\u00b7lulars (EVs) i sistemes h\u00edbrids per al lliurament de f\u00e0rmacs, siRNA i prote\u00efnes.<\/li>\n<li><strong>Nanotecnologies fotot\u00e8rmiques i sensibles a la llum:<\/strong> \u00das de nanomaterials activats per llum i excitaci\u00f3 amb l\u00e0ser polsat per facilitar l&#8217;entrada intracel\u00b7lular, permetre la fuga endos\u00f2mica i eliminar selectivament c\u00e8l\u00b7lules tumorals.<\/li>\n<li><strong>Nanoter\u00e0pies immunomoduladores:<\/strong> Estudi de la interacci\u00f3 dels nanosistemes amb el sistema immunitari i desenvolupament d&#8217;estrat\u00e8gies per induir mort cel\u00b7lular immunog\u00e8nica i generar vacunes contra el c\u00e0ncer.<\/li>\n<li><strong>Desenvolupament de nanomedicina guiat per IA:<\/strong> Aplicaci\u00f3 d&#8217;intel\u00b7lig\u00e8ncia artificial i aprenentatge autom\u00e0tic per dissenyar, optimitzar i predir el rendiment de nanotransportadors en col\u00b7laboraci\u00f3 amb grups de qu\u00edmica computacional.<\/li>\n<li><strong>Models precl\u00ednics i recerca translacional:<\/strong> Avaluaci\u00f3 in vitro i in vivo de sistemes terap\u00e8utics en oncologia i malalties metab\u00f2liques, centrada en efic\u00e0cia, seguretat, biodistribuci\u00f3 i perfil immunol\u00f2gic.<\/li>\n<\/ul>\n","protected":false},"featured_media":11272,"parent":0,"template":"","meta":{"_acf_changed":false},"departamento":[161],"class_list":["post-11271","grupos-investigacion","type-grupos-investigacion","status-publish","has-post-thumbnail","hentry","departamento-tensioactius-i-nanobiotecnologia","entry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.7 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Nanomedicina per a aplicacions terap\u00e8utiques | IQAC - Institut de Qu\u00edmica Avan\u00e7ada de Catalunya - CSIC<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.iqac.csic.es\/ca\/grupos-investigacion\/nanomedicina-per-a-aplicacions-terapeutiques\/\" \/>\n<meta property=\"og:locale\" content=\"ca_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Nanomedicina per a aplicacions terap\u00e8utiques | IQAC - Institut de Qu\u00edmica Avan\u00e7ada de Catalunya - CSIC\" \/>\n<meta property=\"og:description\" content=\"El grup de Nanomedicina per a Aplicacions Terap\u00e8utiques desenvolupa estrat\u00e8gies terap\u00e8utiques avan\u00e7ades basades en el disseny de nano- i biotransportadors intel\u00b7ligents per a l&#8217;administraci\u00f3 dirigida de f\u00e0rmacs, \u00e0cids nucleics i prote\u00efnes. Aquests nanotransportadors estan dissenyats per millorar l&#8217;estabilitat, l&#8217;especificitat i el lliurament intracel\u00b7lular dels agents terap\u00e8utics, augmentant-ne l&#8217;efic\u00e0cia i minimitzant els efectes secundaris. 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