{"id":11492,"date":"2026-06-04T09:33:58","date_gmt":"2026-06-04T07:33:58","guid":{"rendered":"https:\/\/www.iqac.csic.es\/join-iqac\/validacio-dassajos-i-avaluacio-de-compostos\/"},"modified":"2026-06-04T09:33:58","modified_gmt":"2026-06-04T07:33:58","slug":"validacio-dassajos-i-avaluacio-de-compostos","status":"publish","type":"join-iqac","link":"https:\/\/www.iqac.csic.es\/ca\/join-iqac\/validacio-dassajos-i-avaluacio-de-compostos\/","title":{"rendered":"Validaci\u00f3 d&#8217;assajos i avaluaci\u00f3 de compostos"},"content":{"rendered":"<p>L&#8217;Institut de Qu\u00edmica Avan\u00e7ada de Catalunya (IQAC-CSIC) busca contractar una empresa especialitzada per dur a terme la validaci\u00f3 d&#8217;assajos i l&#8217;avaluaci\u00f3 de compostos utilitzant neurones dopamin\u00e8rgiques derivades de c\u00e8l\u00b7lules mare pluripotents.<\/p>\n<h3>Requisits<\/h3>\n<ul>\n<li>Experi\u00e8ncia demostrada en el cultiu de neurones humanes derivades de c\u00e8l\u00b7lules mare pluripotents.<\/li>\n<li>Capacitat demostrada en el desenvolupament i validaci\u00f3 d&#8217;assajos funcionals basats en c\u00e8l\u00b7lules utilitzant neurones dopamin\u00e8rgiques derivades de c\u00e8l\u00b7lules iPS.<\/li>\n<li>Capacitat demostrada en la miniaturitzaci\u00f3 d&#8217;assajos.<\/li>\n<li>Experi\u00e8ncia en l&#8217;aplicaci\u00f3 d&#8217;est\u00edmuls controlats (incloent-hi estimulaci\u00f3 mitjan\u00e7ant llum).<\/li>\n<li>Experi\u00e8ncia en la quantificaci\u00f3 de biomarcadors bioqu\u00edmics en c\u00e8l\u00b7lules derivades d&#8217;iPS.<\/li>\n<li>Experi\u00e8ncia en l&#8217;an\u00e0lisi de corbes dosi-resposta per al perfilat de compostos en format HTS (High Throughput Screening), proporcionant els par\u00e0metres rellevants.<\/li>\n<li>Capacitats per a l&#8217;adquisici\u00f3 i an\u00e0lisi d&#8217;imatges en format HTS.<\/li>\n<\/ul>\n<h3>Abast del Treball<\/h3>\n<h5>Validaci\u00f3 Preliminar<\/h5>\n<ul>\n<li>Assajos inicials amb compostos de refer\u00e8ncia per confirmar el funcionament correcte del sistema experimental.<\/li>\n<li>Optimitzaci\u00f3 de les condicions de l&#8217;assaig, incloent-hi els par\u00e0metres d&#8217;il\u00b7luminaci\u00f3.<\/li>\n<li>Definici\u00f3 de criteris de viabilitat de l&#8217;assaig (GO \/ NO GO).<\/li>\n<\/ul>\n<h5>Validaci\u00f3 de l&#8217;Assaig i Avaluaci\u00f3 de Compostos<\/h5>\n<ul>\n<li>Implementaci\u00f3 de l&#8217;assaig en neurones dopamin\u00e8rgiques derivades de c\u00e8l\u00b7lules mare pluripotents en format miniaturitzat de plaques multipouet de 384 pouets (384 MTP).<\/li>\n<li>Tractament amb compostos de refer\u00e8ncia a diferents concentracions.<\/li>\n<li>Aplicaci\u00f3 de protocols d&#8217;estimulaci\u00f3 lum\u00ednica controlada, incloent-hi les condicions de control apropiades.<\/li>\n<li>Si \u00e9s compatible, avaluaci\u00f3 del cultiu cel\u00b7lular mitjan\u00e7ant adquisici\u00f3 d&#8217;imatges BrightField en format de 384 pouets abans de procedir al pas final i, quan sigui factible, quantificaci\u00f3 de la densitat cel\u00b7lular per proporcionar un \u00edndex<\/li>\n<li>del nombre de c\u00e8l\u00b7lules (viabilitat) despr\u00e9s del tractament.<\/li>\n<li>Quantificaci\u00f3 de dopamina en el sobrenedant cel\u00b7lular mitjan\u00e7ant m\u00e8todes bioqu\u00edmics.<\/li>\n<li>Avaluaci\u00f3 en m\u00faltiples punts temporals despr\u00e9s del tractament.<\/li>\n<\/ul>\n<p>Les empreses amb experi\u00e8ncia rellevant estan convidades a enviar la seva manifestaci\u00f3 d&#8217;inter\u00e8s a <a href=\"mailto:ramona.galatola@iqac.csic.es\" target=\"_blank\" rel=\"noopener\">ramona.galatola@iqac.csic.es<\/a> abans del 14 de juny de 2026.<\/p>\n","protected":false},"featured_media":0,"parent":0,"template":"","meta":{"_acf_changed":false},"tipo-de-contenido":[221,222],"class_list":["post-11492","join-iqac","type-join-iqac","status-publish","hentry","tipo-de-contenido-ofertes-de-treball","tipo-de-contenido-ofertes-perfil-contractant","entry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Validaci\u00f3 d&#039;assajos i avaluaci\u00f3 de compostos | IQAC - Institut de Qu\u00edmica Avan\u00e7ada de Catalunya - CSIC<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.iqac.csic.es\/join-iqac\/validacion-de-ensayos-y-evaluacion-de-compuestos\/\" \/>\n<meta property=\"og:locale\" content=\"ca_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Validaci\u00f3 d&#039;assajos i avaluaci\u00f3 de compostos | IQAC - Institut de Qu\u00edmica Avan\u00e7ada de Catalunya - CSIC\" \/>\n<meta property=\"og:description\" content=\"L&#8217;Institut de Qu\u00edmica Avan\u00e7ada de Catalunya (IQAC-CSIC) busca contractar una empresa especialitzada per dur a terme la validaci\u00f3 d&#8217;assajos i l&#8217;avaluaci\u00f3 de compostos utilitzant neurones dopamin\u00e8rgiques derivades de c\u00e8l\u00b7lules mare pluripotents. Requisits Experi\u00e8ncia demostrada en el cultiu de neurones humanes derivades de c\u00e8l\u00b7lules mare pluripotents. Capacitat demostrada en el desenvolupament i validaci\u00f3 d&#8217;assajos funcionals basatsContinue reading &quot;Validaci\u00f3 d&#8217;assajos i avaluaci\u00f3 de compostos&quot;\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.iqac.csic.es\/join-iqac\/validacion-de-ensayos-y-evaluacion-de-compuestos\/\" \/>\n<meta property=\"og:site_name\" content=\"IQAC - Institut de Qu\u00edmica Avan\u00e7ada de Catalunya - CSIC\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/iqac.csic.es\/\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.iqac.csic.es\/wp-content\/uploads\/2026\/08\/iqac-logo.webp\" \/>\n\t<meta property=\"og:image:width\" content=\"1280\" \/>\n\t<meta property=\"og:image:height\" content=\"720\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/webp\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:site\" content=\"@IQAC_CSIC\" \/>\n<meta name=\"twitter:label1\" content=\"Temps estimat de lectura\" \/>\n\t<meta name=\"twitter:data1\" content=\"2 minuts\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.iqac.csic.es\\\/join-iqac\\\/validacion-de-ensayos-y-evaluacion-de-compuestos\\\/\",\"url\":\"https:\\\/\\\/www.iqac.csic.es\\\/join-iqac\\\/validacion-de-ensayos-y-evaluacion-de-compuestos\\\/\",\"name\":\"Validaci\u00f3 d'assajos i avaluaci\u00f3 de compostos | IQAC - 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Institut de Qu\u00edmica Avan\u00e7ada de Catalunya - CSIC","og_description":"L&#8217;Institut de Qu\u00edmica Avan\u00e7ada de Catalunya (IQAC-CSIC) busca contractar una empresa especialitzada per dur a terme la validaci\u00f3 d&#8217;assajos i l&#8217;avaluaci\u00f3 de compostos utilitzant neurones dopamin\u00e8rgiques derivades de c\u00e8l\u00b7lules mare pluripotents. Requisits Experi\u00e8ncia demostrada en el cultiu de neurones humanes derivades de c\u00e8l\u00b7lules mare pluripotents. 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