{"id":8071,"date":"2020-10-09T10:29:44","date_gmt":"2020-10-09T08:29:44","guid":{"rendered":"https:\/\/www.iqac.csic.es\/un-projecte-busca-desenvolupar-molecules-amb-propietats-neutralitzadors-del-sars-cov-2\/"},"modified":"2026-06-16T10:47:04","modified_gmt":"2026-06-16T08:47:04","slug":"un-projecte-busca-desenvolupar-molecules-amb-propietats-neutralitzadors-del-sars-cov-2","status":"publish","type":"post","link":"https:\/\/www.iqac.csic.es\/ca\/un-projecte-busca-desenvolupar-molecules-amb-propietats-neutralitzadors-del-sars-cov-2\/","title":{"rendered":"Un projecte busca desenvolupar mol\u00e8cules amb propietats neutralitzadors del SARS-CoV-2"},"content":{"rendered":"<p><strong>El\u00a0IQAC-CSIC\u00a0participa en aquest projecte, que aquesta liderat per la Universitat P\u00fablica de Navarra i\u00a0Navarrabiomed, i \u00e9s finan\u00e7at pel Fons Supera Covid-19, del Banc Santander, la\u00a0CRUE\u00a0i el CSIC.<\/strong><\/p>\n<p><a href=\"https:\/\/www.iqac.csic.es\/\">L&#8217;Institut de Qu\u00edmica Avan\u00e7ada de Catalunya (IQAC)<\/a>\u00a0del <a href=\"https:\/\/www.csic.es\/\" target=\"_blank\" rel=\"noopener noreferrer\">Consell Superior de Recerques Cient\u00edfiques (CSIC)<\/a> <strong>participa en nou projecte que busca desenvolupar mol\u00e8cules amb propietats neutralitzadors del\u00a0SARS-CoV-2, causant de la malaltia COVID-19, per al tractament de pacients que requereixen hospitalitzaci\u00f3 i supervisi\u00f3 cl\u00ednica a causa de la gravetat de la infecci\u00f3.<\/strong> Est\u00e0 liderat per la <a href=\"http:\/\/www.unavarra.es\/portada\" target=\"_blank\" rel=\"noopener noreferrer\">Universitat P\u00fablica de Navarra (UPNA)<\/a>\u00a0i\u00a0<a href=\"https:\/\/www.navarrabiomed.es\/es\" target=\"_blank\" rel=\"noopener noreferrer\">Navarrabiomed<\/a>, i compta tamb\u00e9 amb la participaci\u00f3 d&#8217;altres tres institucions de Barcelona: el\u00a0IRB\u00a0Barcelona (<a href=\"https:\/\/www.irbbarcelona.org\/es\" target=\"_blank\" rel=\"noopener noreferrer\">Institut de Recerca Biom\u00e8dica<\/a>), el\u00a0CIBER-*BBN\u00a0(<a href=\"https:\/\/www.ciber-bbn.es\/\" target=\"_blank\" rel=\"noopener noreferrer\">Centre de Recerca Biom\u00e8dica en Xarxa en l&#8217;\u00e0rea tem\u00e0tica de\u00a0Bioingenier\u00eda, Biomaterials i\u00a0Nanomedicina<\/a>)\u00a0i el\u00a0IRTA\u00a0(<a href=\"http:\/\/www.irta.cat\/es\/\" target=\"_blank\" rel=\"noopener noreferrer\">Institut de Recerca i Tecnologia Agroaliment\u00e0ries<\/a>).<\/p>\n<p>Amb una durada prevista dotze mesos, el projecte reuneix un equip multidisciplinari: s\u00edntesi qu\u00edmica, enginyeria de prote\u00efnes, an\u00e0lisi estructural, biologia cel\u00b7lular, aix\u00ed com especialistes en condicions de bioseguretat BSL3 (el tercer nivell de bioseguretat per a laboratoris d&#8217;una escala de quatre) per a poder testar el potencial d&#8217;aquestes mol\u00e8cules.<\/p>\n<p><strong>Reprodueixen el receptor cel\u00b7lular al qual s&#8217;ancora el virus<\/strong><\/p>\n<p>Aquestes mol\u00e8cules amb propietats neutralitzadors del\u00a0SARS-CoV-2\u00a0es basen en p\u00e8ptids espec\u00edfics del receptor\u00a0ACE-2\u00a0capa\u00e7os de reduir o anul\u00b7lar la capacitat d&#8217;infecci\u00f3 de\u00a0SARS-CoV-2. \u201c<em>Es tracta de mol\u00e8cules que reprodueixen la regi\u00f3 del receptor hum\u00e0 a trav\u00e9s del qual s&#8217;ancora el virus<\/em> \u2014explica l&#8217;investigador que lidera el projecte, <strong><a href=\"https:\/\/www.navarrabiomed.es\/es\/directorio\/lopez-sagaseta\" target=\"_blank\" rel=\"noopener noreferrer\">Jacinto L\u00f3pez\u00a0Sagaseta<\/a><\/strong>, de la Unitat de Cristal\u00b7lografia de Prote\u00efnes de\u00a0Navarrabiomed\u00a0(centre de recerca biom\u00e8dica del Govern de Navarra i la\u00a0UPNA)\u2014.<em> Pretenem crear mol\u00e8cules a partir d&#8217;aquesta regi\u00f3 motlle, per\u00f2 amb major capacitat d&#8217;uni\u00f3 a la part\u00edcula viral i que, per tant, dificultarien la uni\u00f3 del virus al receptor natural i el conseg\u00fcent progr\u00e9s de la infecci\u00f3<\/em>\u201d. Segons aquest investigador, aquestes mol\u00e8cules poden \u201c<em>ajudar al disseny de f\u00e0rmacs capa\u00e7os de mitigar el proc\u00e9s i la velocitat de la infecci\u00f3, facilitant aix\u00ed la recuperaci\u00f3 cl\u00ednica del pacient<\/em>\u201d.<\/p>\n<p>La part qu\u00edmica del projecte ser\u00e0 duta a terme per <strong>Miriam Royo<\/strong> i <strong>Daniel\u00a0Pulido<\/strong>, investigadors del grup de <a href=\"https:\/\/www.iqac.csic.es\/research\/departments\/surfactants-and-nanobiotechnology\/multivalent-systems-for-nanomedicine\/\">Sistemes\u00a0Multivalentes\u00a0per a\u00a0Nanomedicina<\/a>\u00a0del\u00a0IQAC, que participen en el disseny i realitzaci\u00f3 de la s\u00edntesi dels\u00a0ligandos\u00a0basats en el receptor\u00a0ACE-2.<\/p>\n<p>El Fons Supera Covid-19, llan\u00e7at per Banc Santander,\u00a0CRUE\u00a0Universitats Espanyoles i el Consell Superior de Recerques Cient\u00edfiques (CSIC), ha concedit 160.000 euros per a donar suport a aquest projecte de recerca.<\/p>\n<p>Els socis del consorci esperen que \u201c<em>la disponibilitat de mol\u00e8cules amb alta efic\u00e0cia inhibit\u00f2ria ajudi substancialment a mitigar l&#8217;impacte socioecon\u00f2mic de la pand\u00e8mia, a causa de la persist\u00e8ncia i\/o futurs brots de\u00a0SARS-*CoV-2\u00a0o altres coronavirus potencialment perillosos i amb rutes d&#8217;entrada similars<\/em>\u201d, en paraules de <strong>Jacinto L\u00f3pez\u00a0Sagaseta<\/strong>.<\/p>\n<p><strong>Un fons de 8,5 milions<\/strong><\/p>\n<p>El Fons Supera Covid-19, dotat amb un total de 8,5 milions d&#8217;euros, ha anat destinat a projectes de diferents entitats desenvolupats sobre tres eixos estrat\u00e8gics enfront de la covid-19: recerca aplicada sobre el virus i la seva prevenci\u00f3, impacte social i enfortiment de la capacitat tecnol\u00f2gica de les universitats, i reducci\u00f3 de la bretxa digital. En concret, es van presentar 700 propostes, de les quals 35 han estat seleccionades per a recerca aplicada contra el virus, cap\u00edtol dotat amb 5 milions d&#8217;euros. A m\u00e9s, s&#8217;han distribu\u00eft prop d&#8217;un mili\u00f3 d&#8217;euros a dotze projectes d&#8217;impacte social. I, finalment, s&#8217;han destinat 2,5 milions d&#8217;euros per a dotar de prop de 5.000 ordinadors i 15.000 solucions de connectivitat a internet i webcams a joves universitaris de tota Espanya que es troben en una situaci\u00f3 socioecon\u00f2mica desfavorable.<\/p>\n<p style=\"text-align: right;\"><strong>Ana Sotres \/ IQAC-CSIC Comunicaci\u00f3<\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"<p>El\u00a0IQAC-CSIC\u00a0participa en aquest projecte, que aquesta liderat per la Universitat P\u00fablica de Navarra i\u00a0Navarrabiomed, i \u00e9s finan\u00e7at pel Fons Supera Covid-19, del Banc Santander, la\u00a0CRUE\u00a0i el CSIC. L&#8217;Institut de Qu\u00edmica Avan\u00e7ada de Catalunya (IQAC)\u00a0del Consell Superior de Recerques Cient\u00edfiques (CSIC) participa en nou projecte que busca desenvolupar mol\u00e8cules amb propietats neutralitzadors del\u00a0SARS-CoV-2, causant de la<a class=\"more-link\" href=\"https:\/\/www.iqac.csic.es\/ca\/un-projecte-busca-desenvolupar-molecules-amb-propietats-neutralitzadors-del-sars-cov-2\/\">Continue reading <span class=\"screen-reader-text\">\u00abUn projecte busca desenvolupar mol\u00e8cules amb propietats neutralitzadors del SARS-CoV-2\u00bb<\/span><\/a><\/p>\n","protected":false},"author":3,"featured_media":4142,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[73],"tags":[],"class_list":["post-8071","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news","entry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.7 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Un projecte busca desenvolupar mol\u00e8cules amb propietats neutralitzadors del SARS-CoV-2 | IQAC - Institut de Qu\u00edmica Avan\u00e7ada de Catalunya - CSIC<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.iqac.csic.es\/un-proyecto-busca-desarrollar-moleculas-con-propiedades-neutralizantes-del-sars-cov-2\/\" \/>\n<meta property=\"og:locale\" content=\"ca_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Un projecte busca desenvolupar mol\u00e8cules amb propietats neutralitzadors del SARS-CoV-2 | IQAC - Institut de Qu\u00edmica Avan\u00e7ada de Catalunya - CSIC\" \/>\n<meta property=\"og:description\" content=\"El\u00a0IQAC-CSIC\u00a0participa en aquest projecte, que aquesta liderat per la Universitat P\u00fablica de Navarra i\u00a0Navarrabiomed, i \u00e9s finan\u00e7at pel Fons Supera Covid-19, del Banc Santander, la\u00a0CRUE\u00a0i el CSIC. 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