{"id":8072,"date":"2020-10-15T11:07:46","date_gmt":"2020-10-15T09:07:46","guid":{"rendered":"https:\/\/www.iqac.csic.es\/investigadors-del-iqac-csic-busquen-reforcar-les-mucoses-nasals-i-orals-per-impermeabilitzar-les-davant-el-sars-cov-2\/"},"modified":"2026-06-16T10:47:04","modified_gmt":"2026-06-16T08:47:04","slug":"investigadors-del-iqac-csic-busquen-reforcar-les-mucoses-nasals-i-orals-per-impermeabilitzar-les-davant-el-sars-cov-2","status":"publish","type":"post","link":"https:\/\/www.iqac.csic.es\/ca\/investigadors-del-iqac-csic-busquen-reforcar-les-mucoses-nasals-i-orals-per-impermeabilitzar-les-davant-el-sars-cov-2\/","title":{"rendered":"Investigadors del IQAC-CSIC busquen refor\u00e7ar les mucoses nasals i orals per impermeabilitzar- les davant el SARS-CoV-2"},"content":{"rendered":"<ul>\n<li><strong>El projecte desenvolupa un aerosol amb l\u00edpids similars als de la pell, que emuli la seva impermeabilitat en aplicar-lo en les mucoses i disminueixi o eviti la penetraci\u00f3 del virus<\/strong><\/li>\n<\/ul>\n<ul>\n<li><strong>L\u2019aerosol podria emprar-se en les mucoses nasals i orals per oferir una protecci\u00f3 complement\u00e0ria a les m\u00e0scares<\/strong><\/li>\n<\/ul>\n<p>Un equip de <a href=\"https:\/\/www.iqac.csic.es\/es\/\">l&#8217;Institut de Qu\u00edmica Avan\u00e7ada de Catalunya<\/a> del <a href=\"https:\/\/www.csic.es\/\" target=\"_blank\" rel=\"noopener noreferrer\">Consell Superior d\u2019Investigacions Cient\u00edfiques<\/a> (IQAC-CSIC), treballa en un projecte que busca <strong>modificar les mucoses nasals i orals amb l&#8217;objectiu de disminuir o prevenir la penetraci\u00f3 del virus\u00a0SARS-CoV-2, causant de la Covid-19. L&#8217;estudi t\u00e9 com a objectiu el desenvolupament d\u2019aerosols que \u2018imitin\u2019 en la seva composici\u00f3 qu\u00edmica i estructural els l\u00edpids de la pell, ja que aquests \u00faltims s\u00f3n m\u00e9s impermeables al coronavirus.<\/strong> D&#8217;aquesta manera, es formarien estructures lip\u00eddiques en les mucoses m\u00e9s refor\u00e7ades que podrien impedir la penetraci\u00f3 del virus.<\/p>\n<p>El coronavirus\u00a0SARS-CoV-2\u00a0s&#8217;infiltra principalment a trav\u00e9s de les mucoses nasals o bucals, en comparaci\u00f3 amb la baixa penetraci\u00f3 a trav\u00e9s de la pell. \u201cEl projecte busca utilitzar aquestes propietats de major impermeabilitat de la pell per a refor\u00e7ar la mucosa, augmentar el seu efecte barrera i disminuir la seva permeabilitat per rebaixar o evitar la penetraci\u00f3 del virus, assenyala <strong>Maria Luisa\u00a0Coderch\u00a0Negra<\/strong>, investigadora del\u00a0IQAC-CSIC\u00a0que dirigeix l&#8217;estudi.<\/p>\n<p>El projecte t\u00e9 l&#8217;objectiu de formular aerosols bucals i nasals amb l\u00edpids similars als que hi s\u00f3n presents en l&#8217;estrat\u00a0corni\u00a0de la pell humana (la capa m\u00e9s externa de l&#8217;epidermis), tot formant una barrera protectora capa\u00e7 d&#8217;impermeabilitzar les mucoses a l&#8217;entrada del virus. Aquesta innovaci\u00f3 no proporcionaria una protecci\u00f3 completa per\u00f2 la disminuci\u00f3 de la permeabilitat podria evitar parcialment la penetraci\u00f3 del virus a nivell sist\u00e8mic i, aix\u00ed, protegir les persones en general i, en particular, el personal sanitari.<\/p>\n<p>Despr\u00e9s d&#8217;optimitzar les metodologies m\u00e9s adequades per avaluar la permeabilitat de les mucoses, els investigadors aplicaran diferents aerosols basats en compostos similars als de la pell sobre mucoses\u00a0bucals\u00a0i nasals i tractaran de determinar, al principi, el seu efecte\u00a0impermeabilitzant\u00a0enfront de l&#8217;aigua. Seguidament, s&#8217;analitzar\u00e0 la capacitat de penetraci\u00f3 d&#8217;un model de virus similar al coronavirus a trav\u00e9s de les mucoses protegides amb el nou aerosol. \u201cAra hi ha un gran mercat per evitar la penetraci\u00f3 del\u00a0SARS-CoV-2\u00a0i tamb\u00e9 d&#8217;altres virus. A m\u00e9s, es poden aplicar formulacions relacionades per\u00a0 evitar la penetraci\u00f3 de t\u00f2xics o contaminants\u201d, explica la doctora\u00a0<strong>Coderch<\/strong>.<\/p>\n<h5><strong>Les barreres de la pell i les mucoses<\/strong><\/h5>\n<p>L&#8217;estrat\u00a0corni\u00a0de la pell \u00e9s la capa m\u00e9s externa de l&#8217;epidermis i est\u00e0 format per unes vint\u00a0subcapes\u00a0de c\u00e8l\u00b7lules mortes i aplanades, els\u00a0corne\u00f2cits, que constitueixen una estructura d&#8217;empaquetament. Entre aquests existeixen unes bicapes lip\u00eddiques perfectament estructurades, compostes per l\u00edpids que contribueixen a crear una barrera protectora pr\u00e0cticament infranquejable (ceramides, \u00e0cids grassos i colesterol). Aquesta capa es torna permeable sols en en cas de ferides, cremades o malalties cut\u00e0nies.<\/p>\n<p>No obstant aix\u00f2, les mucoses, les barreres que cobreixen la boca, faringe, bronquis, pulmons i sistema digestiu, s\u00f3n molt m\u00e9s permeables a les infeccions. \u201cLes mucoses estan obertes al m\u00f3n exterior i per aix\u00f2 disposen de mecanismes enfront dels microbis, com la pres\u00e8ncia d&#8217;enzims en la saliva, o els cilis dels nostres bronquis, que s\u00f3n com petits p\u00e8ls diminuts capa\u00e7os de filtrar l&#8217;aire que respirem. Per\u00f2 aquests mecanismes s\u00f3n insuficients enfront d&#8217;un virus com el\u00a0SARS-Cov-2\u201d, explica la investigadora del CSIC.<\/p>\n<p>\u201cL&#8217;impacte potencial seria enorme si tota la poblaci\u00f3 pogu\u00e9s protegir-se a trav\u00e9s de la mucosa nasal del\u00a0SARS-*CoV-2, fins i tot encara que fos parcialment. Avui dia, l&#8217;\u00fanica protecci\u00f3 contra la infecci\u00f3 de la Covid-19 es basa en l&#8217;\u00fas de m\u00e0scares. No sabem en quina mesura podria reduir-se la permeabilitat, per\u00f2 sempre proporcionaria protecci\u00f3 addicional a la m\u00e0scara\u201d, conclou\u00a0<strong>Coderch<\/strong>.<\/p>\n<p>&nbsp;<\/p>\n<p style=\"text-align: right;\"><strong>IQAC-CSIC Comunicaci\u00f3<\/strong><\/p>\n<h5><\/h5>\n","protected":false},"excerpt":{"rendered":"<p>El projecte desenvolupa un aerosol amb l\u00edpids similars als de la pell, que emuli la seva impermeabilitat en aplicar-lo en les mucoses i disminueixi o eviti la penetraci\u00f3 del virus L\u2019aerosol podria emprar-se en les mucoses nasals i orals per oferir una protecci\u00f3 complement\u00e0ria a les m\u00e0scares Un equip de l&#8217;Institut de Qu\u00edmica Avan\u00e7ada de<a class=\"more-link\" href=\"https:\/\/www.iqac.csic.es\/ca\/investigadors-del-iqac-csic-busquen-reforcar-les-mucoses-nasals-i-orals-per-impermeabilitzar-les-davant-el-sars-cov-2\/\">Continue reading <span class=\"screen-reader-text\">\u00abInvestigadors del IQAC-CSIC busquen refor\u00e7ar les mucoses nasals i orals per impermeabilitzar- les davant el SARS-CoV-2\u00bb<\/span><\/a><\/p>\n","protected":false},"author":3,"featured_media":4144,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[73],"tags":[],"class_list":["post-8072","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news","entry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.7 - 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