{"id":8106,"date":"2021-06-17T10:18:27","date_gmt":"2021-06-17T08:18:27","guid":{"rendered":"https:\/\/www.iqac.csic.es\/cientifics-del-csic-proposen-una-nova-estrategia-per-regular-la-xarxa-de-comunicacio-de-les-cel%c2%b7lules\/"},"modified":"2026-06-16T10:47:06","modified_gmt":"2026-06-16T08:47:06","slug":"cientifics-del-csic-proposen-una-nova-estrategia-per-regular-la-xarxa-de-comunicacio-de-les-cel%c2%b7lules","status":"publish","type":"post","link":"https:\/\/www.iqac.csic.es\/ca\/cientifics-del-csic-proposen-una-nova-estrategia-per-regular-la-xarxa-de-comunicacio-de-les-cel%c2%b7lules\/","title":{"rendered":"Cient\u00edfics del CSIC proposen una nova estrat\u00e8gia per regular la xarxa de comunicaci\u00f3 de les c\u00e8l\u00b7lules"},"content":{"rendered":"<p>Un estudi liderat per cient\u00edfics de <strong>l&#8217;Institut de Qu\u00edmica Avan\u00e7ada de Catalunya (IQAC-CSIC)<\/strong> del <strong><a href=\"https:\/\/www.csic.es\/\" target=\"_blank\" rel=\"noopener\">Consell Superior d\u2019Investigacions Cient\u00edfiques (CSIC)<\/a><\/strong>, en col\u00b7laboraci\u00f3 amb la <a href=\"https:\/\/www.stonybrook.edu\/\" target=\"_blank\" rel=\"noopener\"><strong>Universitat Stony Brook (EEUU<\/strong>)<\/a>, proposa una nova estrat\u00e8gia per al desenvolupament de nous f\u00e0rmacs basats en la inhibici\u00f3 dels enzims tirosina cinases, mol\u00e8cules que activen i desencadenen molts processos cel\u00b7lulars. La recerca ha estat publicada i destacada en la portada interior de la revista <em>Chemistry &#8211; A European Journal<\/em>.<\/p>\n<p>L&#8217;enfocament proposat, nou i poc convencional, es basa en la regulaci\u00f3 de la cascada de senyalitzaci\u00f3 de tirosina cinasa, i podria conduir al desenvolupament d&#8217;eines millorades i m\u00e9s selectives per a la recerca, el diagn\u00f2stic o els tractaments d&#8217;algunes malalties.<\/p>\n<p>Les tirosina cinases s\u00f3n un conjunt d&#8217;enzims fonamentals per a la comunicaci\u00f3 entre les c\u00e8l\u00b7lules de l\u2019organisme, que desencadenen i impulsen reaccions bioqu\u00edmiques\u00a0 importants per a la vida. \u201cLa disfunci\u00f3 d&#8217;aquests enzims est\u00e0 relacionada amb malalties greus com la diabetis, alguns trastorns neurol\u00f2gics i molts tipus de c\u00e0ncer\u201d, explica <strong>Ignacio Alfonso<\/strong>, investigador del IQAC-CSIC.<\/p>\n<h4><strong>Activen vies de senyalitzaci\u00f3 diferents<\/strong><\/h4>\n<p>La senyalitzaci\u00f3 cel\u00b7lular \u00e9s el proc\u00e9s mitjan\u00e7ant el qual es comuniquen les c\u00e8l\u00b7lules. En la c\u00e8l\u00b7lula existeixen molts tipus de receptors o prote\u00efnes espec\u00edfiques que reconeixen les prote\u00efnes sintetitzades pel propi organisme i fan que la c\u00e8l\u00b7lula respongui a elles. Una de les m\u00e9s importants s\u00f3n les tirosina cinases.<\/p>\n<p>\u201cLes c\u00e8l\u00b7lules reben senyals de l&#8217;entorn quan una mol\u00e8cula (una hormona, per exemple) s&#8217;uneix a un d&#8217;aquests receptors. El receptor reconeix la mol\u00e8cula i desencadena una s\u00e8rie de reaccions qu\u00edmiques\u201d, explics Alfonso. Aix\u00f2 permet que les c\u00e8l\u00b7lules treballin per a controlar funcions vitals de l&#8217;organisme, com la multiplicaci\u00f3 o la destrucci\u00f3 cel\u00b7lular. Cada proc\u00e9s t\u00e9 la seva pr\u00f2pia via de senyalitzaci\u00f3. Despr\u00e9s que la primera mol\u00e8cula de la via de senyalitzaci\u00f3 rebi el senyal, s&#8217;activa una altra mol\u00e8cula, despr\u00e9s una altra i una altra, i aix\u00ed successivament durant tota la cascada de senyalitzaci\u00f3 fins que es compleix la funci\u00f3 cel\u00b7lular. \u201cL&#8217;activaci\u00f3 anormal de les vies de senyalitzaci\u00f3 pot arribar a produir malalties, com el c\u00e0ncer\u201d, indica l\u2019investigador.<\/p>\n<p>Les cinases s\u00f3n una fam\u00edlia de mol\u00e8cules que activen moltes vies de senyalitzaci\u00f3 diferents, la qual cosa implica que elles mateixes participen en tots aquests processos. \u201cEn els casos en els quals es vol evitar algun d&#8217;aquests processos, una estrat\u00e8gia de recerca \u00e9s inhibir les cinases, bloquejant-les amb mol\u00e8cules sint\u00e8tiques. Per\u00f2 aquesta estrat\u00e8gia no \u00e9s molt selectiva, ja que es poden estar inhibint altres vies importants\u201d, adverteix Alfonso. De fet, la similitud entre les cinases i la seva versatilitat funcional (la mateixa cinasa actua sobre diferents mol\u00e8cules i est\u00e0 implicada en processos diferents) ha dificultat el disseny d&#8217;inhibidors espec\u00edfics per a modular situacions patol\u00f2giques o disseccionar diferents funcions en recerca b\u00e0sica.<\/p>\n<h4>Objectiu: el lloc on actuen les cinases<\/h4>\n<p>\u00c9s aqu\u00ed on el treball planteja una estrat\u00e8gia alternativa: no inhibir les cinases, sin\u00f3 <em>tapar <\/em>i bloquejar les mol\u00e8cules sobre les quals actuen les cinases. L&#8217;eina per a aix\u00f2 serien receptors sint\u00e8tics artificials, \u00e9s a dir, mol\u00e8cules sint\u00e8tiques que protegirien el lloc on les cinases exerceixen la seva acci\u00f3. \u201cEl nostre grup ha dissenyat mol\u00e8cules que interactuen amb els substrats de la cinasa, i no amb la cinasa\u201d, explica <strong>Alfonso<\/strong>. \u201cHem preparat g\u00e0bies moleculars artificials, compostes per pseudop\u00e8ptids, que s\u00f3n capaces de modular l&#8217;activitat d&#8217;aquests enzims\u201d, aclareix l&#8217;investigador.<\/p>\n<p>\u00abAquest enfocament complementari aplana el cam\u00ed per a la modulaci\u00f3 selectiva d&#8217;una via de senyalitzaci\u00f3 individual estimulada per cinases, sense interferir amb altres funcions de les mateixes cinases\u00bb, explica <strong>Todd Miller<\/strong>, de la Universitat de Stony Brook. \u201cAquesta tecnologia permetria als investigadors analitzar les contribucions de vies de senyalitzaci\u00f3 espec\u00edfiques en la funci\u00f3 cel\u00b7lular\u201d.<\/p>\n<p>A pesar que es tracta d&#8217;una demostraci\u00f3 conceptual, els resultats d\u2019aquest treball podrien conduir a inhibidors m\u00e9s selectius d&#8217;aquestes cinases que s&#8217;utilitzarien com a eines de recerca per a la comprensi\u00f3 completa d&#8217;aquesta complexa xarxa de comunicaci\u00f3. \u201cAquest enfocament genera coneixements b\u00e0sics, que podrien ser fonamentals per a comprendre millor les funcions biol\u00f2giques clau i l&#8217;origen de moltes malalties\u201d, conclou <strong>Ignacio Alfonso<\/strong>.<\/p>\n<p>&nbsp;<\/p>\n<p><em>Luc\u00eda Tapia, Naiara Solozabal, Jordi Sol\u00e0, Yolanda P\u00e9rez, W. Todd Miller, and Ignacio Alfonso. <strong>Modulation of Src Kinase Activity by Selective Substrate Recognition with Pseudopeptidic Cages<\/strong>. ChemEurJ. <strong>DOI: <\/strong><a href=\"https:\/\/doi.org\/10.1002\/chem.202100990\" target=\"_blank\" rel=\"noopener\">10.1002\/chem.202100990<\/a><\/em><br \/>\n&nbsp;<\/p>\n<p style=\"text-align: right;\"><strong>IQAC-CSIC Comunicaci\u00f3<\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Un estudi liderat per cient\u00edfics de l&#8217;Institut de Qu\u00edmica Avan\u00e7ada de Catalunya (IQAC-CSIC) del Consell Superior d\u2019Investigacions Cient\u00edfiques (CSIC), en col\u00b7laboraci\u00f3 amb la Universitat Stony Brook (EEUU), proposa una nova estrat\u00e8gia per al desenvolupament de nous f\u00e0rmacs basats en la inhibici\u00f3 dels enzims tirosina cinases, mol\u00e8cules que activen i desencadenen molts processos cel\u00b7lulars. La recerca<a class=\"more-link\" href=\"https:\/\/www.iqac.csic.es\/ca\/cientifics-del-csic-proposen-una-nova-estrategia-per-regular-la-xarxa-de-comunicacio-de-les-cel%c2%b7lules\/\">Continue reading <span class=\"screen-reader-text\">\u00abCient\u00edfics del CSIC proposen una nova estrat\u00e8gia per regular la xarxa de comunicaci\u00f3 de les c\u00e8l\u00b7lules\u00bb<\/span><\/a><\/p>\n","protected":false},"author":3,"featured_media":8107,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[73],"tags":[],"class_list":["post-8106","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news","entry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.7 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Cient\u00edfics del CSIC proposen una nova estrat\u00e8gia per regular la xarxa de comunicaci\u00f3 de les c\u00e8l\u00b7lules | IQAC - Institut de Qu\u00edmica Avan\u00e7ada de Catalunya - CSIC<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.iqac.csic.es\/cientificos-del-csic-proponen-una-nueva-estrategia-para-regular-la-red-de-comunicacion-de-las-celulas\/\" \/>\n<meta property=\"og:locale\" content=\"ca_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Cient\u00edfics del CSIC proposen una nova estrat\u00e8gia per regular la xarxa de comunicaci\u00f3 de les c\u00e8l\u00b7lules | IQAC - Institut de Qu\u00edmica Avan\u00e7ada de Catalunya - CSIC\" \/>\n<meta property=\"og:description\" content=\"Un estudi liderat per cient\u00edfics de l&#8217;Institut de Qu\u00edmica Avan\u00e7ada de Catalunya (IQAC-CSIC) del Consell Superior d\u2019Investigacions Cient\u00edfiques (CSIC), en col\u00b7laboraci\u00f3 amb la Universitat Stony Brook (EEUU), proposa una nova estrat\u00e8gia per al desenvolupament de nous f\u00e0rmacs basats en la inhibici\u00f3 dels enzims tirosina cinases, mol\u00e8cules que activen i desencadenen molts processos cel\u00b7lulars. 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