{"id":8171,"date":"2022-06-21T10:50:42","date_gmt":"2022-06-21T08:50:42","guid":{"rendered":"https:\/\/www.iqac.csic.es\/investigadors-del-csic-desenvolupen-molecules-foto-regulables-que-controlen-el-ritme-cardiac-mitjancant-llum\/"},"modified":"2026-06-16T10:47:10","modified_gmt":"2026-06-16T08:47:10","slug":"investigadors-del-csic-desenvolupen-molecules-foto-regulables-que-controlen-el-ritme-cardiac-mitjancant-llum","status":"publish","type":"post","link":"https:\/\/www.iqac.csic.es\/ca\/investigadors-del-csic-desenvolupen-molecules-foto-regulables-que-controlen-el-ritme-cardiac-mitjancant-llum\/","title":{"rendered":"Investigadors del CSIC desenvolupen mol\u00e8cules foto-regulables que controlen el ritme card\u00edac mitjan\u00e7ant llum"},"content":{"rendered":"<p>Investigadors de l\u2019<a href=\"https:\/\/www.iqac.csic.es\/\" target=\"_blank\" rel=\"noopener\">Institut de Qu\u00edmica Avan\u00e7ada de Catalunya (IQAC)<\/a>, en col\u00b7laboraci\u00f3 amb l\u2019<a href=\"https:\/\/www.idaea.csic.es\/\" target=\"_blank\" rel=\"noopener\">Institut de Diagnosi Ambiental i Estudis de l\u2019Aigua (IDAEA)<\/a> del <a href=\"https:\/\/www.csic.es\/es\" target=\"_blank\" rel=\"noopener\">Consell Superior d\u2019Investigacions Cient\u00edfiques (CSIC)<\/a> han desenvolupat mol\u00e8cules que permeten controlar mitjan\u00e7ant la llum l&#8217;activitat dels receptors beta adren\u00e8rgics localitzats en els cardiomi\u00f2cits, c\u00e8l\u00b7lules del m\u00fascul card\u00edac. Aquesta recerca, publicada en la revista <em>Angewandte Chemie International Edition<\/em> i provada en models de peix zebra, mostra el potencial de la fotofarmacologia (f\u00e0rmacs controlats mitjan\u00e7ant llum) per a l&#8217;estudi i control de la fisiologia card\u00edaca, i la seva aplicabilitat en \u00e9ssers vius. A m\u00e9s, els resultats d&#8217;aquest treball apunten a la generaci\u00f3 de futures ter\u00e0pies m\u00e9s precises i amb menys efectes secundaris.<\/p>\n<p>Els receptors adren\u00e8rgics, localitzats en la superf\u00edcie de les c\u00e8l\u00b7lules, s\u00f3n activats per unes subst\u00e0ncies anomenades catecolamines (adrenalina i noradrenalina) i la seva regulaci\u00f3 \u00e9s essencial per al correcte funcionament del cor i de molts altres processos fisiol\u00f2gics. Un d&#8217;aquests receptors \u00e9s l&#8217;anomenat receptor \u03b2-adren\u00e8rgic, que es troba en el cor, les art\u00e8ries i els pulmons. Amb l&#8217;arribada de les catecolamines, aquests receptors s&#8217;estimulen, tot elevant la freq\u00fc\u00e8ncia card\u00edaca i la broncodilataci\u00f3, entre molts altres efectes. Aquests receptors s\u00f3n la principal diana terap\u00e8utica de f\u00e0rmacs de primera l\u00ednia com els antiasm\u00e0tics o els betabloquejants.<\/p>\n<p>Els betabloquejants es troben entre els f\u00e0rmacs m\u00e9s receptats a nivell mundial i serveixen per a tractar diverses patologies card\u00edaques, en particular en el tractament dels trastorns del ritme card\u00edac i en la cardioprotecci\u00f3 posterior a un infart de miocardi. Aquests f\u00e0rmacs bloquegen el receptor \u03b2-adren\u00e8rgic, de tal forma que impedeix la uni\u00f3 de les catecolamines i evita la seva estimulaci\u00f3, millorant la funci\u00f3 del cor. No obstant aix\u00f2, alguns malalts amb problemes respiratoris poden desenvolupar efectes secundaris.<\/p>\n<p>En aquest estudi, es van dissenyar i produir diverses mol\u00e8cules foto-regulables amb activitat betabloquejant. \u201cAquest treball presenta una nova estrat\u00e8gia per al control amb un alt nivell de precisi\u00f3 del receptor \u03b21-adren\u00e8rgic mitjan\u00e7ant mol\u00e8cules fotosensibles\u201d, explica <strong>Xavier Rovira<\/strong>, investigador del grup Qu\u00edmica M\u00e8dica en el IQAC. \u201cEls fotof\u00e0rmacs poden activar-se i desactivar-se mitjan\u00e7ant la llum amb un gran control en el lloc d&#8217;acci\u00f3 i durant el moment i temps desitjat, obrint aix\u00ed nous camins cap a ter\u00e0pies altament espec\u00edfiques i amb menors efectes indesitjables que sorgeixen per l&#8217;acci\u00f3 dels f\u00e0rmacs en altres \u00f2rgans\u201d, aclareix l&#8217;investigador.<\/p>\n<p>De manera destacable, en aquest treball es demostra que amb aquestes mol\u00e8cules foto-regulables, que posseeixen una pot\u00e8ncia i selectivitat similar a la dels betabloquejants aprovats, es pot augmentar i disminuir el ritme card\u00edac mitjan\u00e7ant l&#8217;\u00fas de llum de diferents colors. Aquestes mol\u00e8cules van ser provades en assajos in vitro, i en larves vives de peix zebra. \u201cAquest estudi confirma l&#8217;enorme potencial del peix zebra com a model de vertebrat en estudis de fotofarmacologia card\u00edaca\u201c, indica <strong>Demetrio Rald\u00faa<\/strong>, investigador del grup Toxicologia Ambiental en el IDAEA.<\/p>\n<p>Aquest treball proporciona la primera prova de concepte del potencial de la fotofarmacologia per a l&#8217;estudi i control de la fisiologia card\u00edaca en entorns natius sense necessitat de modificaci\u00f3 gen\u00e8tica, on el \u03b21-adren\u00e8rgic juga un paper fonamental. Aquest tipus de mol\u00e8cules podrien complir amb els procediments i requisits de f\u00e0rmacs convencionals que desenvolupen les empreses farmac\u00e8utiques.<\/p>\n<p>\u201cEn el futur es desenvoluparan mol\u00e8cules amb diferents capacitats de control per llum per a futures aplicacions en recerca i s&#8217;espera que aquest i futurs treballs inspirin el desenvolupament de tractaments per a malalties card\u00edaques molt m\u00e9s eficients i amb menors efectes secundaris per als pacients\u201d, conclou <strong>Rovira<\/strong>.<\/p>\n<p>&nbsp;<\/p>\n<p>Anna Duran-Corbera, Melissa Faria, Yuanyuan Ma, Eva Prats, Andr\u00e9 Dias, Juanlo Catena, Karen L. Martinez, Demetrio Raldua, Amadeu Llebaria, Xavier Rovira. <strong>A Photoswitchable Ligand Targering the<\/strong> <strong>\u03b21-Adrenoceptor Enables Light-Control of the Cardiac Rhythm<\/strong>. <em>Angewandte Chemie. Int. Ed<\/em>. <a href=\"https:\/\/onlinelibrary.wiley.com\/doi\/full\/10.1002\/anie.202203449\" target=\"_blank\" rel=\"noopener\">DOI: 10.1002\/anie.202203449<\/a><\/p>\n<p style=\"text-align: right;\"><strong>Ana Sotres \/ IQAC-CSIC Comunicaci\u00f3<\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Investigadors de l\u2019Institut de Qu\u00edmica Avan\u00e7ada de Catalunya (IQAC), en col\u00b7laboraci\u00f3 amb l\u2019Institut de Diagnosi Ambiental i Estudis de l\u2019Aigua (IDAEA) del Consell Superior d\u2019Investigacions Cient\u00edfiques (CSIC) han desenvolupat mol\u00e8cules que permeten controlar mitjan\u00e7ant la llum l&#8217;activitat dels receptors beta adren\u00e8rgics localitzats en els cardiomi\u00f2cits, c\u00e8l\u00b7lules del m\u00fascul card\u00edac. Aquesta recerca, publicada en la revista<a class=\"more-link\" href=\"https:\/\/www.iqac.csic.es\/ca\/investigadors-del-csic-desenvolupen-molecules-foto-regulables-que-controlen-el-ritme-cardiac-mitjancant-llum\/\">Continue reading <span class=\"screen-reader-text\">\u00abInvestigadors del CSIC desenvolupen mol\u00e8cules foto-regulables que controlen el ritme card\u00edac mitjan\u00e7ant llum\u00bb<\/span><\/a><\/p>\n","protected":false},"author":3,"featured_media":8172,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[73],"tags":[],"class_list":["post-8171","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news","entry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.7 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Investigadors del CSIC desenvolupen mol\u00e8cules foto-regulables que controlen el ritme card\u00edac mitjan\u00e7ant llum | IQAC - Institut de Qu\u00edmica Avan\u00e7ada de Catalunya - CSIC<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.iqac.csic.es\/investigadores-del-csic-desarrollan-moleculas-fotoregulables-que-controlan-el-ritmo-cardiaco-mediante-luz\/\" \/>\n<meta property=\"og:locale\" content=\"ca_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Investigadors del CSIC desenvolupen mol\u00e8cules foto-regulables que controlen el ritme card\u00edac mitjan\u00e7ant llum | IQAC - Institut de Qu\u00edmica Avan\u00e7ada de Catalunya - CSIC\" \/>\n<meta property=\"og:description\" content=\"Investigadors de l\u2019Institut de Qu\u00edmica Avan\u00e7ada de Catalunya (IQAC), en col\u00b7laboraci\u00f3 amb l\u2019Institut de Diagnosi Ambiental i Estudis de l\u2019Aigua (IDAEA) del Consell Superior d\u2019Investigacions Cient\u00edfiques (CSIC) han desenvolupat mol\u00e8cules que permeten controlar mitjan\u00e7ant la llum l&#8217;activitat dels receptors beta adren\u00e8rgics localitzats en els cardiomi\u00f2cits, c\u00e8l\u00b7lules del m\u00fascul card\u00edac. 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