{"id":8276,"date":"2024-09-04T09:03:13","date_gmt":"2024-09-04T07:03:13","guid":{"rendered":"https:\/\/www.iqac.csic.es\/un-estudi-liderat-pel-csic-avanca-en-leliminacio-selectiva-de-cel%c2%b7lules-canceroses-mitjancant-gabies-moleculars\/"},"modified":"2026-06-16T10:47:24","modified_gmt":"2026-06-16T08:47:24","slug":"un-estudi-liderat-pel-csic-avanca-en-leliminacio-selectiva-de-cel%c2%b7lules-canceroses-mitjancant-gabies-moleculars","status":"publish","type":"post","link":"https:\/\/www.iqac.csic.es\/ca\/un-estudi-liderat-pel-csic-avanca-en-leliminacio-selectiva-de-cel%c2%b7lules-canceroses-mitjancant-gabies-moleculars\/","title":{"rendered":"Un estudi liderat pel CSIC avan\u00e7a en l&#8217;eliminaci\u00f3 selectiva de c\u00e8l\u00b7lules canceroses mitjan\u00e7ant \u2018g\u00e0bies\u2019 moleculars"},"content":{"rendered":"<p>La quimioter\u00e0pia salva vides de pacients amb c\u00e0ncer. Tanmateix, aquests tractaments no estan exempts d&#8217;efectes secundaris i altres limitacions, per la qual cosa la investigaci\u00f3 b\u00e0sica se centra a superar aquests reptes. Aix\u00f2 ho demostra un estudi recentment publicat a la revista Cell Reports Physical Science, que ha proposat l&#8217;\u00fas de \u2018g\u00e0bies\u2019 moleculars (formades per pseudopeptids) per eliminar c\u00e8l\u00b7lules canceroses de manera selectiva en microambients \u00e0cids. Per a aix\u00f2, s&#8217;ha realitzat un estudi exhaustiu amb una \u00e0mplia fam\u00edlia de \u2018g\u00e0bies\u2019 per entendre com actuen. El treball est\u00e0 liderat per un equip cient\u00edfic de l&#8217;<a href=\"https:\/\/www.iqac.csic.es\/ca\/\" target=\"_blank\" rel=\"noopener\"><strong>Institut de Qu\u00edmica Avan\u00e7ada de Catalunya (IQAC-CSIC)<\/strong><\/a>, del <a href=\"https:\/\/www.csic.es\/es\" target=\"_blank\" rel=\"noopener\"><strong>Consell Superior d&#8217;Investigacions Cient\u00edfiques (CSIC)<\/strong><\/a>, en col\u00b7laboraci\u00f3 amb la <a href=\"https:\/\/www.ubu.es\/\" target=\"_blank\" rel=\"noopener\"><strong>Universitat de Burgos (UBU)<\/strong><\/a> i compta amb la participaci\u00f3 de l&#8217;<a href=\"https:\/\/www.idaea.csic.es\/\" target=\"_blank\" rel=\"noopener\"><strong>Institut de Diagn\u00f2stic Ambiental i Estudis de l&#8217;Aigua (IDAEA-CSIC)<\/strong><\/a>.<\/p>\n<p>Aquests resultats s\u00f3n rellevants per al desenvolupament precl\u00ednic de nous ion\u00f2fors (mol\u00e8cules transportadores d&#8217;ions) amb potencial aplicaci\u00f3 terap\u00e8utica en el tractament contra el c\u00e0ncer.<\/p>\n<h5>Reptes en la lluita contra el c\u00e1ncer<\/h5>\n<p>La quimioter\u00e0pia contra el c\u00e0ncer s\u2019enfronta a dos desafiaments principals: la falta de selectivitat, que provoca efectes secundaris indesitjables, i l\u2019aparici\u00f3 de quimiorresist\u00e8ncia, ja que les c\u00e8l\u00b7lules poden generar resist\u00e8ncia als agents qu\u00edmics utilitzats, fent que els tractaments siguin inefectius per a alguns pacients. A m\u00e9s, una de les caracter\u00edstiques de les c\u00e8l\u00b7lules canceroses \u00e9s que el seu metabolisme genera un pH \u00e0cid en l\u2019entorn dels tumors s\u00f2lids, cosa que confereix caracter\u00edstiques especials a aquestes c\u00e8l\u00b7lules, fent-les m\u00e9s resistents i capaces de migrar a altres zones del cos (met\u00e0stasi).<\/p>\n<p>Hi ha una evid\u00e8ncia creixent del potencial dels ion\u00f2fors (mol\u00e8cules transportadores d\u2019ions) com a nous quimioterap\u00e8utics en el c\u00e0ncer. No obstant aix\u00f2, controlar la seva activitat per limitar la seva toxicitat ha estat una tasca dif\u00edcil fins ara. L\u2019\u00fas de \u2018g\u00e0bies\u2019 moleculars que actuen selectivament en el pH lleugerament \u00e0cid del microambient dels tumors s\u00f2lids \u00e9s una manera de superar aquests obstacles i avan\u00e7ar en el seu desenvolupament.<\/p>\n<h5>\u2018G\u00e0bies\u2019 moleculars per destruir c\u00e8l\u00b7lules canceroses<\/h5>\n<p>Aquestes \u2018g\u00e0bies\u2019 derivades d&#8217;amino\u00e0cids substitu\u00efts amb fluor maten les c\u00e8l\u00b7lules canceroses en valors de pH lleugerament \u00e0cids (per sota de 7, que s\u00f3n les xifres observades al voltant dels tumors), per\u00f2 s\u00f3n inofensives per al pH fisiol\u00f2gic dels teixits sans. \u201cEn un estudi anterior, <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/31298461\/\" target=\"_blank\" rel=\"noopener\">publicat el 2019<\/a>, vam dissenyar una mol\u00e8cula amb estructura tridimensional en forma de \u2018g\u00e0bia\u2019 que mostrava una bona selectivitat per matar c\u00e8l\u00b7lules canceroses en entorns lleugerament \u00e0cids\u201d, explica <strong>Ignacio Alfonso<\/strong>, investigador de l\u2019IQAC-CSIC i autor principal de l\u2019estudi. Aquestes \u2018g\u00e0bies\u2019 tenien un \u00e0tom de fluor en cada una de les tres cadenes laterals i, quan es trobaven en mitjans \u00e0cids, encapsulaven un clorur a l\u2019interior de manera molt efica\u00e7. A m\u00e9s, eren capaces de transportar el clorur a trav\u00e9s de bicapes lip\u00eddiques, sent aquest transport tamb\u00e9 m\u00e9s eficient quan hi havia un gradient de pH amb un entorn \u00e0cid, resultant aix\u00ed m\u00e9s t\u00f2xiques per a aquelles c\u00e8l\u00b7lules que es troben en un pH lleugerament \u00e0cid com el microentorn d\u2019un tumor s\u00f2lid.<\/p>\n<blockquote><p>\u201cEn aquest treball vol\u00edem anar una mica m\u00e9s enll\u00e0 i entendre el mecanisme d\u2019acci\u00f3 d\u2019aquestes mol\u00e8cules\u201d, explica l\u2019investigador de l\u2019IQAC-CSIC. \u201cPer aix\u00f2, s\u2019ha realitzat un estudi exhaustiu amb una fam\u00edlia \u00e0mplia de \u2018g\u00e0bies\u2019 amb un nombre diferent d\u2019\u00e0toms de fluor en diverses posicions per entendre la capacitat de capturar clorur, el proc\u00e9s de transport i la toxicitat a diferents pH en cultius cel\u00b7lulars\u201d, aclareix <strong>Alfonso<\/strong>.<\/p><\/blockquote>\n<p>El proc\u00e9s s\u2019ha estudiat exhaustivament a nivell molecular utilitzant enfocaments te\u00f2rics i experimentals d\u2019\u00faltima generaci\u00f3, com ara fluoresc\u00e8ncia, resson\u00e0ncia magn\u00e8tica nuclear i estudis computacionals. Els resultats mostren l\u2019efecte del fluor sobre aquestes mol\u00e8cules i han perm\u00e8s entendre el mecanisme d\u2019acci\u00f3, aix\u00ed com identificar una mol\u00e8cula amb una selectivitat encara m\u00e9s gran per eliminar c\u00e8l\u00b7lules de c\u00e0ncer en entorns \u00e0cids.<\/p>\n<blockquote><p>\u201cAquests resultats ajudaran a comprendre i millorar el disseny d\u2019aquest tipus d\u2019ion\u00f2fors amb potencial aplicaci\u00f3 terap\u00e8utica en el tractament contra el c\u00e0ncer\u201d, conclou <strong>Roberto Quesada<\/strong>, investigador de la Universitat de Burgos.<\/p><\/blockquote>\n<p>&nbsp;<\/p>\n<p style=\"font-size: 75%;\">Luc\u00eda Tapia, Yolanda P\u00e9rez, Israel Carreira-Barral, Jordi Bujons, Michael Bolte, Carmen Bedia, Roberto Quesada and Ignacio Alfonso. <a href=\"https:\/\/www.cell.com\/cell-reports-physical-science\/fulltext\/S2666-3864(24)00437-5\" target=\"_blank\" rel=\"noopener\"><strong>Tuning pH-dependent cytotoxicity in cancer cells by peripheral fluorine substitution on pseudopeptidic cages<\/strong><\/a>. Cell Reports Physical Science. <a href=\"https:\/\/www.cell.com\/cell-reports-physical-science\/fulltext\/S2666-3864(24)00437-5\" target=\"_blank\" rel=\"noopener\">DOI: 10.1016\/j.xcrp.2024.102152<\/a><\/p>\n<p>&nbsp;<\/p>\n<p style=\"text-align: right;\"><strong>IQAC-CSIC Comunicaci\u00f3<\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"<p>La quimioter\u00e0pia salva vides de pacients amb c\u00e0ncer. Tanmateix, aquests tractaments no estan exempts d&#8217;efectes secundaris i altres limitacions, per la qual cosa la investigaci\u00f3 b\u00e0sica se centra a superar aquests reptes. Aix\u00f2 ho demostra un estudi recentment publicat a la revista Cell Reports Physical Science, que ha proposat l&#8217;\u00fas de \u2018g\u00e0bies\u2019 moleculars (formades per<a class=\"more-link\" href=\"https:\/\/www.iqac.csic.es\/ca\/un-estudi-liderat-pel-csic-avanca-en-leliminacio-selectiva-de-cel%c2%b7lules-canceroses-mitjancant-gabies-moleculars\/\">Continue reading <span class=\"screen-reader-text\">\u00abUn estudi liderat pel CSIC avan\u00e7a en l&#8217;eliminaci\u00f3 selectiva de c\u00e8l\u00b7lules canceroses mitjan\u00e7ant \u2018g\u00e0bies\u2019 moleculars\u00bb<\/span><\/a><\/p>\n","protected":false},"author":3,"featured_media":4471,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[73],"tags":[],"class_list":["post-8276","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news","entry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.7 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Un estudi liderat pel CSIC avan\u00e7a en l&#039;eliminaci\u00f3 selectiva de c\u00e8l\u00b7lules canceroses mitjan\u00e7ant \u2018g\u00e0bies\u2019 moleculars | IQAC - Institut de Qu\u00edmica Avan\u00e7ada de Catalunya - CSIC<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.iqac.csic.es\/un-estudio-liderado-por-el-csic-avanza-en-la-eliminacion-selectiva-de-celulas-cancerosas-mediante-jaulas-moleculares\/\" \/>\n<meta property=\"og:locale\" content=\"ca_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Un estudi liderat pel CSIC avan\u00e7a en l&#039;eliminaci\u00f3 selectiva de c\u00e8l\u00b7lules canceroses mitjan\u00e7ant \u2018g\u00e0bies\u2019 moleculars | IQAC - Institut de Qu\u00edmica Avan\u00e7ada de Catalunya - CSIC\" \/>\n<meta property=\"og:description\" content=\"La quimioter\u00e0pia salva vides de pacients amb c\u00e0ncer. Tanmateix, aquests tractaments no estan exempts d&#8217;efectes secundaris i altres limitacions, per la qual cosa la investigaci\u00f3 b\u00e0sica se centra a superar aquests reptes. Aix\u00f2 ho demostra un estudi recentment publicat a la revista Cell Reports Physical Science, que ha proposat l&#8217;\u00fas de \u2018g\u00e0bies\u2019 moleculars (formades perContinue reading &quot;Un estudi liderat pel CSIC avan\u00e7a en l&#8217;eliminaci\u00f3 selectiva de c\u00e8l\u00b7lules canceroses mitjan\u00e7ant \u2018g\u00e0bies\u2019 moleculars&quot;\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.iqac.csic.es\/un-estudio-liderado-por-el-csic-avanza-en-la-eliminacion-selectiva-de-celulas-cancerosas-mediante-jaulas-moleculares\/\" \/>\n<meta property=\"og:site_name\" content=\"IQAC - Institut de Qu\u00edmica Avan\u00e7ada de Catalunya - CSIC\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/iqac.csic.es\/\" \/>\n<meta property=\"article:published_time\" content=\"2024-09-04T07:03:13+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2026-06-16T08:47:24+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.iqac.csic.es\/wp-content\/uploads\/2026\/06\/20190507-010-30-1.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1600\" \/>\n\t<meta property=\"og:image:height\" content=\"1200\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Ana Sotres\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@IQAC_CSIC\" \/>\n<meta name=\"twitter:site\" content=\"@IQAC_CSIC\" \/>\n<meta name=\"twitter:label1\" content=\"Escrit per\" \/>\n\t<meta name=\"twitter:data1\" content=\"Ana Sotres\" \/>\n\t<meta name=\"twitter:label2\" content=\"Temps estimat de lectura\" \/>\n\t<meta name=\"twitter:data2\" content=\"4 minuts\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/www.iqac.csic.es\\\/un-estudio-liderado-por-el-csic-avanza-en-la-eliminacion-selectiva-de-celulas-cancerosas-mediante-jaulas-moleculares\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.iqac.csic.es\\\/un-estudio-liderado-por-el-csic-avanza-en-la-eliminacion-selectiva-de-celulas-cancerosas-mediante-jaulas-moleculares\\\/\"},\"author\":{\"name\":\"Ana Sotres\",\"@id\":\"https:\\\/\\\/www.iqac.csic.es\\\/#\\\/schema\\\/person\\\/ac65d00561d3a6d2810128c46771aff7\"},\"headline\":\"Un estudi liderat pel CSIC avan\u00e7a en l&#8217;eliminaci\u00f3 selectiva de c\u00e8l\u00b7lules canceroses mitjan\u00e7ant \u2018g\u00e0bies\u2019 moleculars\",\"datePublished\":\"2024-09-04T07:03:13+00:00\",\"dateModified\":\"2026-06-16T08:47:24+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/www.iqac.csic.es\\\/un-estudio-liderado-por-el-csic-avanza-en-la-eliminacion-selectiva-de-celulas-cancerosas-mediante-jaulas-moleculares\\\/\"},\"wordCount\":829,\"publisher\":{\"@id\":\"https:\\\/\\\/www.iqac.csic.es\\\/#organization\"},\"image\":{\"@id\":\"https:\\\/\\\/www.iqac.csic.es\\\/un-estudio-liderado-por-el-csic-avanza-en-la-eliminacion-selectiva-de-celulas-cancerosas-mediante-jaulas-moleculares\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/www.iqac.csic.es\\\/wp-content\\\/uploads\\\/2026\\\/06\\\/20190507-010-30-1.jpg\",\"articleSection\":[\"News\"],\"inLanguage\":\"ca\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.iqac.csic.es\\\/un-estudio-liderado-por-el-csic-avanza-en-la-eliminacion-selectiva-de-celulas-cancerosas-mediante-jaulas-moleculares\\\/\",\"url\":\"https:\\\/\\\/www.iqac.csic.es\\\/un-estudio-liderado-por-el-csic-avanza-en-la-eliminacion-selectiva-de-celulas-cancerosas-mediante-jaulas-moleculares\\\/\",\"name\":\"Un estudi liderat pel CSIC avan\u00e7a en l'eliminaci\u00f3 selectiva de c\u00e8l\u00b7lules canceroses mitjan\u00e7ant \u2018g\u00e0bies\u2019 moleculars | IQAC - Institut de Qu\u00edmica Avan\u00e7ada de Catalunya - CSIC\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.iqac.csic.es\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/www.iqac.csic.es\\\/un-estudio-liderado-por-el-csic-avanza-en-la-eliminacion-selectiva-de-celulas-cancerosas-mediante-jaulas-moleculares\\\/#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/www.iqac.csic.es\\\/un-estudio-liderado-por-el-csic-avanza-en-la-eliminacion-selectiva-de-celulas-cancerosas-mediante-jaulas-moleculares\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/www.iqac.csic.es\\\/wp-content\\\/uploads\\\/2026\\\/06\\\/20190507-010-30-1.jpg\",\"datePublished\":\"2024-09-04T07:03:13+00:00\",\"dateModified\":\"2026-06-16T08:47:24+00:00\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/www.iqac.csic.es\\\/un-estudio-liderado-por-el-csic-avanza-en-la-eliminacion-selectiva-de-celulas-cancerosas-mediante-jaulas-moleculares\\\/#breadcrumb\"},\"inLanguage\":\"ca\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/www.iqac.csic.es\\\/un-estudio-liderado-por-el-csic-avanza-en-la-eliminacion-selectiva-de-celulas-cancerosas-mediante-jaulas-moleculares\\\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"ca\",\"@id\":\"https:\\\/\\\/www.iqac.csic.es\\\/un-estudio-liderado-por-el-csic-avanza-en-la-eliminacion-selectiva-de-celulas-cancerosas-mediante-jaulas-moleculares\\\/#primaryimage\",\"url\":\"https:\\\/\\\/www.iqac.csic.es\\\/wp-content\\\/uploads\\\/2026\\\/06\\\/20190507-010-30-1.jpg\",\"contentUrl\":\"https:\\\/\\\/www.iqac.csic.es\\\/wp-content\\\/uploads\\\/2026\\\/06\\\/20190507-010-30-1.jpg\",\"width\":1600,\"height\":1200},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/www.iqac.csic.es\\\/un-estudio-liderado-por-el-csic-avanza-en-la-eliminacion-selectiva-de-celulas-cancerosas-mediante-jaulas-moleculares\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Portada\",\"item\":\"https:\\\/\\\/www.iqac.csic.es\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Un estudi liderat pel CSIC avan\u00e7a en l&#8217;eliminaci\u00f3 selectiva de c\u00e8l\u00b7lules canceroses mitjan\u00e7ant \u2018g\u00e0bies\u2019 moleculars\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/www.iqac.csic.es\\\/#website\",\"url\":\"https:\\\/\\\/www.iqac.csic.es\\\/\",\"name\":\"IQAC - Institut de Qu\u00edmica Avan\u00e7ada de Catalunya - CSIC\",\"description\":\"Chemistry for a better life\",\"publisher\":{\"@id\":\"https:\\\/\\\/www.iqac.csic.es\\\/#organization\"},\"alternateName\":\"IQAC - Institut de Qu\u00edmica Avan\u00e7ada de Catalunya - CSIC\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/www.iqac.csic.es\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"ca\"},{\"@type\":\"Organization\",\"@id\":\"https:\\\/\\\/www.iqac.csic.es\\\/#organization\",\"name\":\"IQAC - Institut de Qu\u00edmica Avan\u00e7ada de Catalunya - CSIC\",\"alternateName\":\"IQAC - Institut de Qu\u00edmica Avan\u00e7ada de Catalunya - CSIC\",\"url\":\"https:\\\/\\\/www.iqac.csic.es\\\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"ca\",\"@id\":\"https:\\\/\\\/www.iqac.csic.es\\\/#\\\/schema\\\/logo\\\/image\\\/\",\"url\":\"https:\\\/\\\/www.iqac.csic.es\\\/wp-content\\\/uploads\\\/2025\\\/11\\\/cropped-favicon-1.png\",\"contentUrl\":\"https:\\\/\\\/www.iqac.csic.es\\\/wp-content\\\/uploads\\\/2025\\\/11\\\/cropped-favicon-1.png\",\"width\":512,\"height\":512,\"caption\":\"IQAC - Institut de Qu\u00edmica Avan\u00e7ada de Catalunya - CSIC\"},\"image\":{\"@id\":\"https:\\\/\\\/www.iqac.csic.es\\\/#\\\/schema\\\/logo\\\/image\\\/\"},\"sameAs\":[\"https:\\\/\\\/www.facebook.com\\\/iqac.csic.es\\\/\",\"https:\\\/\\\/x.com\\\/IQAC_CSIC\",\"https:\\\/\\\/www.instagram.com\\\/iqac_csic\",\"https:\\\/\\\/www.youtube.com\\\/channel\\\/UC1JXTOe3-s8UnYu_A6-SI3A\",\"https:\\\/\\\/www.linkedin.com\\\/company\\\/iqac-csic\\\/\"]},{\"@type\":\"Person\",\"@id\":\"https:\\\/\\\/www.iqac.csic.es\\\/#\\\/schema\\\/person\\\/ac65d00561d3a6d2810128c46771aff7\",\"name\":\"Ana Sotres\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"ca\",\"@id\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/25826e5f3a7a258c44e58bdd075d81df4fb82260d2ac4db8eb7f8a34fe10b563?s=96&d=mm&r=g\",\"url\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/25826e5f3a7a258c44e58bdd075d81df4fb82260d2ac4db8eb7f8a34fe10b563?s=96&d=mm&r=g\",\"contentUrl\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/25826e5f3a7a258c44e58bdd075d81df4fb82260d2ac4db8eb7f8a34fe10b563?s=96&d=mm&r=g\",\"caption\":\"Ana Sotres\"},\"sameAs\":[\"https:\\\/\\\/www.iqac.csic.es\\\/\"]}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Un estudi liderat pel CSIC avan\u00e7a en l'eliminaci\u00f3 selectiva de c\u00e8l\u00b7lules canceroses mitjan\u00e7ant \u2018g\u00e0bies\u2019 moleculars | IQAC - Institut de Qu\u00edmica Avan\u00e7ada de Catalunya - CSIC","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.iqac.csic.es\/un-estudio-liderado-por-el-csic-avanza-en-la-eliminacion-selectiva-de-celulas-cancerosas-mediante-jaulas-moleculares\/","og_locale":"ca_ES","og_type":"article","og_title":"Un estudi liderat pel CSIC avan\u00e7a en l'eliminaci\u00f3 selectiva de c\u00e8l\u00b7lules canceroses mitjan\u00e7ant \u2018g\u00e0bies\u2019 moleculars | IQAC - Institut de Qu\u00edmica Avan\u00e7ada de Catalunya - CSIC","og_description":"La quimioter\u00e0pia salva vides de pacients amb c\u00e0ncer. Tanmateix, aquests tractaments no estan exempts d&#8217;efectes secundaris i altres limitacions, per la qual cosa la investigaci\u00f3 b\u00e0sica se centra a superar aquests reptes. Aix\u00f2 ho demostra un estudi recentment publicat a la revista Cell Reports Physical Science, que ha proposat l&#8217;\u00fas de \u2018g\u00e0bies\u2019 moleculars (formades perContinue reading \"Un estudi liderat pel CSIC avan\u00e7a en l&#8217;eliminaci\u00f3 selectiva de c\u00e8l\u00b7lules canceroses mitjan\u00e7ant \u2018g\u00e0bies\u2019 moleculars\"","og_url":"https:\/\/www.iqac.csic.es\/un-estudio-liderado-por-el-csic-avanza-en-la-eliminacion-selectiva-de-celulas-cancerosas-mediante-jaulas-moleculares\/","og_site_name":"IQAC - Institut de Qu\u00edmica Avan\u00e7ada de Catalunya - CSIC","article_publisher":"https:\/\/www.facebook.com\/iqac.csic.es\/","article_published_time":"2024-09-04T07:03:13+00:00","article_modified_time":"2026-06-16T08:47:24+00:00","og_image":[{"width":1600,"height":1200,"url":"https:\/\/www.iqac.csic.es\/wp-content\/uploads\/2026\/06\/20190507-010-30-1.jpg","type":"image\/jpeg"}],"author":"Ana Sotres","twitter_card":"summary_large_image","twitter_creator":"@IQAC_CSIC","twitter_site":"@IQAC_CSIC","twitter_misc":{"Escrit per":"Ana Sotres","Temps estimat de lectura":"4 minuts"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/www.iqac.csic.es\/un-estudio-liderado-por-el-csic-avanza-en-la-eliminacion-selectiva-de-celulas-cancerosas-mediante-jaulas-moleculares\/#article","isPartOf":{"@id":"https:\/\/www.iqac.csic.es\/un-estudio-liderado-por-el-csic-avanza-en-la-eliminacion-selectiva-de-celulas-cancerosas-mediante-jaulas-moleculares\/"},"author":{"name":"Ana Sotres","@id":"https:\/\/www.iqac.csic.es\/#\/schema\/person\/ac65d00561d3a6d2810128c46771aff7"},"headline":"Un estudi liderat pel CSIC avan\u00e7a en l&#8217;eliminaci\u00f3 selectiva de c\u00e8l\u00b7lules canceroses mitjan\u00e7ant \u2018g\u00e0bies\u2019 moleculars","datePublished":"2024-09-04T07:03:13+00:00","dateModified":"2026-06-16T08:47:24+00:00","mainEntityOfPage":{"@id":"https:\/\/www.iqac.csic.es\/un-estudio-liderado-por-el-csic-avanza-en-la-eliminacion-selectiva-de-celulas-cancerosas-mediante-jaulas-moleculares\/"},"wordCount":829,"publisher":{"@id":"https:\/\/www.iqac.csic.es\/#organization"},"image":{"@id":"https:\/\/www.iqac.csic.es\/un-estudio-liderado-por-el-csic-avanza-en-la-eliminacion-selectiva-de-celulas-cancerosas-mediante-jaulas-moleculares\/#primaryimage"},"thumbnailUrl":"https:\/\/www.iqac.csic.es\/wp-content\/uploads\/2026\/06\/20190507-010-30-1.jpg","articleSection":["News"],"inLanguage":"ca"},{"@type":"WebPage","@id":"https:\/\/www.iqac.csic.es\/un-estudio-liderado-por-el-csic-avanza-en-la-eliminacion-selectiva-de-celulas-cancerosas-mediante-jaulas-moleculares\/","url":"https:\/\/www.iqac.csic.es\/un-estudio-liderado-por-el-csic-avanza-en-la-eliminacion-selectiva-de-celulas-cancerosas-mediante-jaulas-moleculares\/","name":"Un estudi liderat pel CSIC avan\u00e7a en l'eliminaci\u00f3 selectiva de c\u00e8l\u00b7lules canceroses mitjan\u00e7ant \u2018g\u00e0bies\u2019 moleculars | IQAC - Institut de Qu\u00edmica Avan\u00e7ada de Catalunya - CSIC","isPartOf":{"@id":"https:\/\/www.iqac.csic.es\/#website"},"primaryImageOfPage":{"@id":"https:\/\/www.iqac.csic.es\/un-estudio-liderado-por-el-csic-avanza-en-la-eliminacion-selectiva-de-celulas-cancerosas-mediante-jaulas-moleculares\/#primaryimage"},"image":{"@id":"https:\/\/www.iqac.csic.es\/un-estudio-liderado-por-el-csic-avanza-en-la-eliminacion-selectiva-de-celulas-cancerosas-mediante-jaulas-moleculares\/#primaryimage"},"thumbnailUrl":"https:\/\/www.iqac.csic.es\/wp-content\/uploads\/2026\/06\/20190507-010-30-1.jpg","datePublished":"2024-09-04T07:03:13+00:00","dateModified":"2026-06-16T08:47:24+00:00","breadcrumb":{"@id":"https:\/\/www.iqac.csic.es\/un-estudio-liderado-por-el-csic-avanza-en-la-eliminacion-selectiva-de-celulas-cancerosas-mediante-jaulas-moleculares\/#breadcrumb"},"inLanguage":"ca","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.iqac.csic.es\/un-estudio-liderado-por-el-csic-avanza-en-la-eliminacion-selectiva-de-celulas-cancerosas-mediante-jaulas-moleculares\/"]}]},{"@type":"ImageObject","inLanguage":"ca","@id":"https:\/\/www.iqac.csic.es\/un-estudio-liderado-por-el-csic-avanza-en-la-eliminacion-selectiva-de-celulas-cancerosas-mediante-jaulas-moleculares\/#primaryimage","url":"https:\/\/www.iqac.csic.es\/wp-content\/uploads\/2026\/06\/20190507-010-30-1.jpg","contentUrl":"https:\/\/www.iqac.csic.es\/wp-content\/uploads\/2026\/06\/20190507-010-30-1.jpg","width":1600,"height":1200},{"@type":"BreadcrumbList","@id":"https:\/\/www.iqac.csic.es\/un-estudio-liderado-por-el-csic-avanza-en-la-eliminacion-selectiva-de-celulas-cancerosas-mediante-jaulas-moleculares\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Portada","item":"https:\/\/www.iqac.csic.es\/"},{"@type":"ListItem","position":2,"name":"Un estudi liderat pel CSIC avan\u00e7a en l&#8217;eliminaci\u00f3 selectiva de c\u00e8l\u00b7lules canceroses mitjan\u00e7ant \u2018g\u00e0bies\u2019 moleculars"}]},{"@type":"WebSite","@id":"https:\/\/www.iqac.csic.es\/#website","url":"https:\/\/www.iqac.csic.es\/","name":"IQAC - Institut de Qu\u00edmica Avan\u00e7ada de Catalunya - CSIC","description":"Chemistry for a better life","publisher":{"@id":"https:\/\/www.iqac.csic.es\/#organization"},"alternateName":"IQAC - Institut de Qu\u00edmica Avan\u00e7ada de Catalunya - CSIC","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.iqac.csic.es\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"ca"},{"@type":"Organization","@id":"https:\/\/www.iqac.csic.es\/#organization","name":"IQAC - Institut de Qu\u00edmica Avan\u00e7ada de Catalunya - CSIC","alternateName":"IQAC - Institut de Qu\u00edmica Avan\u00e7ada de Catalunya - CSIC","url":"https:\/\/www.iqac.csic.es\/","logo":{"@type":"ImageObject","inLanguage":"ca","@id":"https:\/\/www.iqac.csic.es\/#\/schema\/logo\/image\/","url":"https:\/\/www.iqac.csic.es\/wp-content\/uploads\/2025\/11\/cropped-favicon-1.png","contentUrl":"https:\/\/www.iqac.csic.es\/wp-content\/uploads\/2025\/11\/cropped-favicon-1.png","width":512,"height":512,"caption":"IQAC - Institut de Qu\u00edmica Avan\u00e7ada de Catalunya - CSIC"},"image":{"@id":"https:\/\/www.iqac.csic.es\/#\/schema\/logo\/image\/"},"sameAs":["https:\/\/www.facebook.com\/iqac.csic.es\/","https:\/\/x.com\/IQAC_CSIC","https:\/\/www.instagram.com\/iqac_csic","https:\/\/www.youtube.com\/channel\/UC1JXTOe3-s8UnYu_A6-SI3A","https:\/\/www.linkedin.com\/company\/iqac-csic\/"]},{"@type":"Person","@id":"https:\/\/www.iqac.csic.es\/#\/schema\/person\/ac65d00561d3a6d2810128c46771aff7","name":"Ana Sotres","image":{"@type":"ImageObject","inLanguage":"ca","@id":"https:\/\/secure.gravatar.com\/avatar\/25826e5f3a7a258c44e58bdd075d81df4fb82260d2ac4db8eb7f8a34fe10b563?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/25826e5f3a7a258c44e58bdd075d81df4fb82260d2ac4db8eb7f8a34fe10b563?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/25826e5f3a7a258c44e58bdd075d81df4fb82260d2ac4db8eb7f8a34fe10b563?s=96&d=mm&r=g","caption":"Ana Sotres"},"sameAs":["https:\/\/www.iqac.csic.es\/"]}]}},"_links":{"self":[{"href":"https:\/\/www.iqac.csic.es\/ca\/wp-json\/wp\/v2\/posts\/8276","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.iqac.csic.es\/ca\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.iqac.csic.es\/ca\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.iqac.csic.es\/ca\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/www.iqac.csic.es\/ca\/wp-json\/wp\/v2\/comments?post=8276"}],"version-history":[{"count":1,"href":"https:\/\/www.iqac.csic.es\/ca\/wp-json\/wp\/v2\/posts\/8276\/revisions"}],"predecessor-version":[{"id":8485,"href":"https:\/\/www.iqac.csic.es\/ca\/wp-json\/wp\/v2\/posts\/8276\/revisions\/8485"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.iqac.csic.es\/ca\/wp-json\/wp\/v2\/media\/4471"}],"wp:attachment":[{"href":"https:\/\/www.iqac.csic.es\/ca\/wp-json\/wp\/v2\/media?parent=8276"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.iqac.csic.es\/ca\/wp-json\/wp\/v2\/categories?post=8276"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.iqac.csic.es\/ca\/wp-json\/wp\/v2\/tags?post=8276"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}