{"id":8280,"date":"2024-10-09T08:04:26","date_gmt":"2024-10-09T06:04:26","guid":{"rendered":"https:\/\/www.iqac.csic.es\/nanotecnologia-per-a-frenar-el-creixement-de-glioblastomes\/"},"modified":"2026-06-16T10:47:27","modified_gmt":"2026-06-16T08:47:27","slug":"nanotecnologia-per-a-frenar-el-creixement-de-glioblastomes","status":"publish","type":"post","link":"https:\/\/www.iqac.csic.es\/ca\/nanotecnologia-per-a-frenar-el-creixement-de-glioblastomes\/","title":{"rendered":"Nanotecnologia per a frenar el creixement de glioblastomes"},"content":{"rendered":"<p>Cada 9 d&#8217;octubre se celebra el <strong>Dia de la Nanotecnologia<\/strong>, disciplina encarregada en la comprensi\u00f3 i l&#8217;\u00fas de la mat\u00e8ria a una escala nanom\u00e8trica per a fins, per exemple, industrials o metges. La nanotecnologia juga un paper fonamental en moltes de les l\u00ednies de recerca que es desenvolupen en l&#8217;<strong>Institut de Qu\u00edmica Avan\u00e7ada de Catalunya<\/strong> (<a href=\"https:\/\/www.iqac.csic.es\/\" target=\"_blank\" rel=\"noopener\">IQAC-CSIC<\/a>).<\/p>\n<p>Un dels projectes que podem destacar en aquesta \u00e0rea, el projecte <strong>ReachGlio<\/strong>, est\u00e0 centrat en millorar l&#8217;arribada de f\u00e0rmacs dissenyats per a frenar el creixement dels glioblastomes mitjan\u00e7ant l&#8217;\u00fas de nanomedicinas multifuncionals. \u201cEl nostre objectiu \u00e9s arribar a proposar un o diversos assajos cl\u00ednics en pacients amb glioblastoma usant nanomedicinas, que arribin de manera eficient al cervell i que tinguin activitat antitumoral\u201d, explica <strong>Ibane Abasolo<\/strong>, investigadora principal del projecte.<\/p>\n<p>ReachGlio pertany a la convocat\u00f2ria <strong>TRANSCAN 3<\/strong>, en el qual participen set entitats europees, dues d&#8217;ella espanyoles: <strong>L&#8217;Institut de Salut Carles III<\/strong> (<a href=\"https:\/\/www.isciii.es\/\" target=\"_blank\" rel=\"noopener\">ISCIII<\/a>) i el <strong>Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Bioingenier\u00eda, Biomateriales y Nanomedicina<\/strong> (<a href=\"https:\/\/www.ciber-bbn.es\/\" target=\"_blank\" rel=\"noopener\">CIBER-BBN<\/a>). L&#8217;<strong>Institut de Qu\u00edmica Avan\u00e7ada de Catalunya<\/strong> (<a href=\"https:\/\/www.iqac.csic.es\/\" target=\"_blank\" rel=\"noopener\">IQAC-CSIC<\/a>) participa a trav\u00e9s dels grups CIBER-BBN de les investigadores Miriam Royo i Ibane Abasolo.<\/p>\n<h5><strong>Nanomedicinas amb activitat antitumoral<\/strong><\/h5>\n<p>Els glioblastomes s\u00f3n un dels tumors m\u00e9s agressius que existeixen, degut sobretot a la seva localitzaci\u00f3 dins del cervell i a la seva capacitat per a envair el teixit que els envolta. A m\u00e9s, s\u00f3n tumors molt heterogenis. Tot aix\u00f2 explica per qu\u00e8 el pron\u00f2stic dels pacients amb aquesta mena de tumors continua sent molt dolent sense opcions de ter\u00e0pia curativa per a ells.<\/p>\n<p>\u201cUn dels principals problemes que tenen els f\u00e0rmacs dissenyats per a frenar el creixement dels glioblastomes \u00e9s el dif\u00edcil que resulta que arribin de manera efectiva al cervell i que es distribueixin homog\u00e8niament en aquest tumor amb zones tan diferents\u201d, aclareix <strong>Miriam Royo<\/strong>, investigadora del projecte.<\/p>\n<p>Per a eliminar aquest obstacle, el present projecte planteja <strong>l&#8217;\u00fas de nanopart\u00edcules que incorporen f\u00e0rmacs ja existents<\/strong> que, encara que ja han demostrat que s\u00f3n capa\u00e7os de frenar les c\u00e8l\u00b7lules tumorals, tenen un dif\u00edcil acc\u00e9s al cervell. Aquestes nanopart\u00edcules, en concret micel\u00b7les polim\u00e8riques, porten en la seva superf\u00edcie petites seq\u00fc\u00e8ncies de p\u00e8ptids que actuen com a mol\u00e8cules direccionalizadoras. Aquests p\u00e8ptids faciliten que les nanopart\u00edcules puguin travessar la barrera hematoencef\u00e0lica, entre els vasos sanguinis i el cervell i, a m\u00e9s, dins del cervell, les dirigeixen cap a les c\u00e8l\u00b7lules tumorals.<\/p>\n<p>En el transcurs del projecte es provar\u00e0 tamb\u00e9 un f\u00e0rmac (NGR-TNF) que fa la barrera hematoencef\u00e0lica m\u00e9s permeable, en combinaci\u00f3 amb tractaments antitumorals o b\u00e9 amb les nanomedicinas que estan desenvolupant. \u201cAquesta part espec\u00edficament, est\u00e0 plantejada que es testi a nivell veterinari en gossos que ja sofreixen espont\u00e0niament de tumors cerebrals, per la qual cosa esperem que els resultats del projecte puguin arribar de manera r\u00e0pida als pacients amb glioblastoma\u201d, afegeix <strong>Ibane Abasolo<\/strong>.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Cada 9 d&#8217;octubre se celebra el Dia de la Nanotecnologia, disciplina encarregada en la comprensi\u00f3 i l&#8217;\u00fas de la mat\u00e8ria a una escala nanom\u00e8trica per a fins, per exemple, industrials o metges. La nanotecnologia juga un paper fonamental en moltes de les l\u00ednies de recerca que es desenvolupen en l&#8217;Institut de Qu\u00edmica Avan\u00e7ada de Catalunya<a class=\"more-link\" href=\"https:\/\/www.iqac.csic.es\/ca\/nanotecnologia-per-a-frenar-el-creixement-de-glioblastomes\/\">Continue reading <span class=\"screen-reader-text\">\u00abNanotecnologia per a frenar el creixement de glioblastomes\u00bb<\/span><\/a><\/p>\n","protected":false},"author":3,"featured_media":4482,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[73],"tags":[],"class_list":["post-8280","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news","entry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.7 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Nanotecnologia per a frenar el creixement de glioblastomes | IQAC - Institut de Qu\u00edmica Avan\u00e7ada de Catalunya - CSIC<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.iqac.csic.es\/nanotecnologia-para-frenar-el-crecimiento-de-glioblastomas\/\" \/>\n<meta property=\"og:locale\" content=\"ca_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Nanotecnologia per a frenar el creixement de glioblastomes | IQAC - Institut de Qu\u00edmica Avan\u00e7ada de Catalunya - CSIC\" \/>\n<meta property=\"og:description\" content=\"Cada 9 d&#8217;octubre se celebra el Dia de la Nanotecnologia, disciplina encarregada en la comprensi\u00f3 i l&#8217;\u00fas de la mat\u00e8ria a una escala nanom\u00e8trica per a fins, per exemple, industrials o metges. 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