{"id":8288,"date":"2024-12-03T08:35:06","date_gmt":"2024-12-03T07:35:06","guid":{"rendered":"https:\/\/www.iqac.csic.es\/dissenyen-una-eina-terapeutica-per-inhibir-la-proliferacio-del-virus-sars-cov-2-que-va-causar-la-covid-19\/"},"modified":"2026-06-16T10:47:28","modified_gmt":"2026-06-16T08:47:28","slug":"dissenyen-una-eina-terapeutica-per-inhibir-la-proliferacio-del-virus-sars-cov-2-que-va-causar-la-covid-19","status":"publish","type":"post","link":"https:\/\/www.iqac.csic.es\/ca\/dissenyen-una-eina-terapeutica-per-inhibir-la-proliferacio-del-virus-sars-cov-2-que-va-causar-la-covid-19\/","title":{"rendered":"Dissenyen una eina terap\u00e8utica per inhibir la proliferaci\u00f3 del virus SARS-CoV-2 que va causar la COVID-19"},"content":{"rendered":"<p>Una recerca liderada per la <strong>Universitat de Barcelona<\/strong> i de l\u2019<strong>Institut de Qu\u00edmica Avan\u00e7ada de Catalunya (IQAC-CSIC)<\/strong> presenta una nova eina terap\u00e8utica que \u00e9s capa\u00e7 d\u2019inhibir la proliferaci\u00f3 del virus SARS-CoV-2 que va causar la COVID-19. Els resultats obren noves perspectives en la lluita contra la COVID-19 i altres malalties v\u00edriques que encara no disposen de cap tractament m\u00e8dic, com \u00e9s el cas del virus de la febre hemorr\u00e0gica de Crimea-Congo (CCHFV).<\/p>\n<p>La recerca, publicada a la revista <a href=\"https:\/\/www.jbc.org\/article\/S0021-9258(24)02386-X\/fulltext\" target=\"_blank\" rel=\"noopener\"><em>The Journal of Biological Chemistry<\/em><\/a>, est\u00e0 dirigida pels experts <strong>Carlos J. Ciudad<\/strong> i <strong>Ver\u00f3nica No\u00e9<\/strong>, de la Facultat de Farm\u00e0cia i Ci\u00e8ncies de l\u2019Alimentaci\u00f3 i l\u2019Institut de Nanoci\u00e8ncia i Nanotecnologia (IN2UB) de la UB, en col\u00b7laboraci\u00f3 amb <strong>Ram\u00f3n Eritja<\/strong> i <strong>Anna Avi\u00f1\u00f3<\/strong>, de l\u2019IQAC-CSIC i el CIBER de Bioenginyeria, Biomaterials i Nanomedicina (CIBER-BBN). Tamb\u00e9 hi han tingut una participaci\u00f3 destacada els investigadors <strong>Miguel Chill\u00f3n<\/strong>, de l\u2019Institut de Neuroci\u00e8ncies de la Universitat Aut\u00f2noma de Barcelona (INc-UAB), i <strong>Noem\u00ed Sevilla<\/strong>, del Centre d\u2019Investigaci\u00f3 en Sanitat Animal (CISA, INIA, CSIC). La recerca tamb\u00e9 ha rebut el suport de La Marat\u00f3 de TV3 de 2020 dedicada a impulsar la recerca contra la COVID-19.<\/p>\n<h5><strong>Pinces de polipurines per inhibir el virus responsable de la COVID-19<\/strong><\/h5>\n<p>El maig de 2023, l&#8217;Organitzaci\u00f3 Mundial de la Salut va declarar que la pand\u00e8mia de COVID-19 ja no era una emerg\u00e8ncia mundial. Tot i aix\u00f2, el virus SARS-CoV-2 encara est\u00e0 infectant un elevat nombre de persones a tot el m\u00f3n.<\/p>\n<p>La nova metodologia es basa en la capacitat d\u2019unes mol\u00e8cules conegudes com <em>pinces de polipurines<\/em> (PPRH) per frenar la replicaci\u00f3 del virus SARS-CoV-2. Aquest \u00e9s el primer treball cient\u00edfic que descriu com les PPRHs (<em>PolyPurine Reverse Hoogsteen hairpins<\/em>) poden actuar com a agents terap\u00e8utics i inhibir el creixement d\u2019un virus patog\u00e8nic.<\/p>\n<p>Les PPRH s\u00f3n unes mol\u00e8cules curtes i senzilles d\u2019ADN -una sola cadena formada per oligonucle\u00f2tids- que tenen una alta afinitat per seq\u00fc\u00e8ncies espec\u00edfiques d\u2019ARN. L\u2019estudi revela per primer cop com unes pinces de polipurines -la CC1-PPRH i la CC3-PPRH- s\u00f3n capaces de bloquejar l\u2019activitat d\u2019aquest virus que t\u00e9 ARN com a material gen\u00e8tic.<\/p>\n<blockquote><p>\u00abEn concret, un dels bra\u00e7os de cada cadena de les polipurines CC1-PPRH i CC3-PPRH s\u2019uneix de manera espec\u00edfica a un fragment del genoma d\u2019ARN del virus\u00a0 -una seq\u00fc\u00e8ncia de\u00a0 polipirimidines- mitjan\u00e7ant enlla\u00e7os de Watson-Crick\u00bb, detalla el catedr\u00e0tic <strong>Carlos J. Ciudad<\/strong>, del Departament de Bioqu\u00edmica i Fisiologia de la UB.<\/p><\/blockquote>\n<p>\u00abEspec\u00edficament, el CC1-PPRH s\u2019uneix a la regi\u00f3 de l\u2019ARN que codifica l\u2019enzim replicasa -imprescindible per a la replicaci\u00f3 del virus- mentre que el CC3-PPRH s\u2019uneix a la regi\u00f3 codificant de la prote\u00efna Spike, que t\u00e9 un paper clau en la infecci\u00f3 en les c\u00e8l.lules humanes\u00bb, detalla l\u2019investigador.<\/p>\n<p>La nova t\u00e8cnica terap\u00e8utica s\u2019ha validat <em>in vivo<\/em> en models animals de laboratori que expressen el receptor hum\u00e0 ACE2, amb la col\u00b7laboraci\u00f3 del Centre d\u2019Investigaci\u00f3 en Sanitat Animal (CISA, CSIC). En els equipaments del Centre de Biotecnologia Animal i de Ter\u00e0pia G\u00e8nica (CBATEG-UAB), s\u2019han fet estudis <em>in vitro<\/em> en c\u00e8l.lules Vero E6 de primat que tenen el receptor ACE2 com a via d\u2019entrada del virus del SARS-CoV-2<\/p>\n<p>\u00abEls resultats mostren que tant CC1-PPRH com CC3-PPRH s\u00f3n molt efectives en les c\u00e8l.lules Vero E6. En el cas dels ratolins transg\u00e8nics, el CC1-PPRH s\u2019uneix de manera espec\u00edfica a la zona del genoma que codifica per la prote\u00efna replicasa, de manera que s\u2019inhibeix la replicaci\u00f3 del virus\u00bb, revela l\u2019expert.<\/p>\n<h5><strong>De la detecci\u00f3 de virus a la ter\u00e0pia anticancerosa <\/strong><\/h5>\n<p>Aquests resultats obren una nova via en la lluita antiviral i amplien les aplicacions biom\u00e8diques de les\u00a0 PPRH des de l\u2019\u00e0mbit diagn\u00f2stic fins a l\u2019acci\u00f3 terap\u00e8utica. Anteriorment, l\u2019equip havia descrit l\u2019\u00fas de les pinces de polipurines com un nou m\u00e8tode diagn\u00f2stic per detectar virus d\u2019ARN com el SARS-CoV-2 (<a href=\"https:\/\/web.ub.edu\/web\/actualitat\/w\/nou-m%C3%A8tode-per-detectar-virus-d-arn-com-el-sars-cov-2\" target=\"_blank\" rel=\"noopener\"><em>International Journal of Molecular Sciences<\/em>,<\/a> 2023). La metodologia, m\u00e9s efectiva i r\u00e0pida que la prova PCR, es basa en l\u2019alta afinitat de les pinces de polipurines (PPRH) per capturar l\u2019ARN viral i configurar un senyal de detecci\u00f3 de l\u2019agent viral quan contacta amb les mostres del pacient afectat. Aquesta t\u00e8cnica de detecci\u00f3 es coneix com TENADA (Triplex Enhanced NucleicAcid Detection Assay).<\/p>\n<p>A banda de la detecci\u00f3 del virus SARS-CoV-2, la t\u00e8cnica TENADA tamb\u00e9 es pot fer servir per detectar el virus de la influenza o grip A (H1N1) i el virus respiratori sincitial (RSV), que causa patologies respirat\u00f2ries. \u00abTamb\u00e9 s\u2019apliquen en t\u00e8cniques diagn\u00f2stiques en altres \u00e0mbits de la biomedicina: s\u00f3n biosensors per determinar el grau de metilaci\u00f3 del gen <em>PAX-5<\/em> en el c\u00e0ncer, i tamb\u00e9 per detectar el gen que codifica la subunitat ribosomal mtLSU rRNA en el fong <em>Pneumocystis jirovecii<\/em>, responsable de pneum\u00f2nies greus\u00bb, detalla l\u2019investigador.<\/p>\n<p>En la ter\u00e0pia contra el c\u00e0ncer, les pinces de polipurines s\u2019han aplicat amb \u00e8xit per silenciar l\u2019expressi\u00f3 g\u00e8nica de diferents gens relacionats amb el c\u00e0ncer -s\u00edntesi de telomerasa, survivina, topoisomerasa, etc- i dianes no tractables amb medicaci\u00f3 (els gens <em>K-Ras<\/em> i <em>c-Myc<\/em>). Tamb\u00e9 s\u2019han utilitzat com a eines per a la reparaci\u00f3 de mutacions puntuals en el locus endogen d\u2019un gen i per t\u00e8cniques d\u2019edici\u00f3 g\u00e8nica relacionades amb el salt de l\u2019ex\u00f3 (<em>exon skipping).<\/em><\/p>\n<p>&nbsp;<\/p>\n<p style=\"font-size: 75%;\">Ciudad, Carlos J.; Valiuska, Simona; Rojas, Jos\u00e9 Manuel et al. <a href=\"https:\/\/www.jbc.org\/article\/S0021-9258(24)02386-X\/fulltext\">\u00abPolypurine reverse hoogsteen hairpins as a therapeutic tool for SARS-CoV-2 infection\u00bb<\/a>. <strong>The Journal of Biological Chemistry<\/strong>, octubre de 2024. DOI: 10.1016\/j.jbc.2024.107884<\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Una recerca liderada per la Universitat de Barcelona i de l\u2019Institut de Qu\u00edmica Avan\u00e7ada de Catalunya (IQAC-CSIC) presenta una nova eina terap\u00e8utica que \u00e9s capa\u00e7 d\u2019inhibir la proliferaci\u00f3 del virus SARS-CoV-2 que va causar la COVID-19. Els resultats obren noves perspectives en la lluita contra la COVID-19 i altres malalties v\u00edriques que encara no disposen<a class=\"more-link\" href=\"https:\/\/www.iqac.csic.es\/ca\/dissenyen-una-eina-terapeutica-per-inhibir-la-proliferacio-del-virus-sars-cov-2-que-va-causar-la-covid-19\/\">Continue reading <span class=\"screen-reader-text\">\u00abDissenyen una eina terap\u00e8utica per inhibir la proliferaci\u00f3 del virus SARS-CoV-2 que va causar la COVID-19\u00bb<\/span><\/a><\/p>\n","protected":false},"author":3,"featured_media":4495,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[73],"tags":[],"class_list":["post-8288","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news","entry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.7 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Dissenyen una eina terap\u00e8utica per inhibir la proliferaci\u00f3 del virus SARS-CoV-2 que va causar la COVID-19 | IQAC - Institut de Qu\u00edmica Avan\u00e7ada de Catalunya - CSIC<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.iqac.csic.es\/disenan-una-herramienta-terapeutica-para-inhibir-la-proliferacion-del-virus-sars-cov-2-que-causo-la-covid-19\/\" \/>\n<meta property=\"og:locale\" content=\"ca_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Dissenyen una eina terap\u00e8utica per inhibir la proliferaci\u00f3 del virus SARS-CoV-2 que va causar la COVID-19 | IQAC - Institut de Qu\u00edmica Avan\u00e7ada de Catalunya - CSIC\" \/>\n<meta property=\"og:description\" content=\"Una recerca liderada per la Universitat de Barcelona i de l\u2019Institut de Qu\u00edmica Avan\u00e7ada de Catalunya (IQAC-CSIC) presenta una nova eina terap\u00e8utica que \u00e9s capa\u00e7 d\u2019inhibir la proliferaci\u00f3 del virus SARS-CoV-2 que va causar la COVID-19. 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