{"id":8330,"date":"2025-10-07T08:05:49","date_gmt":"2025-10-07T06:05:49","guid":{"rendered":"https:\/\/www.iqac.csic.es\/descobreixen-un-compost-que-podria-canviar-el-tractament-de-les-lesions-cerebrals-traumatiques\/"},"modified":"2026-06-16T10:47:33","modified_gmt":"2026-06-16T08:47:33","slug":"descobreixen-un-compost-que-podria-canviar-el-tractament-de-les-lesions-cerebrals-traumatiques","status":"publish","type":"post","link":"https:\/\/www.iqac.csic.es\/ca\/descobreixen-un-compost-que-podria-canviar-el-tractament-de-les-lesions-cerebrals-traumatiques\/","title":{"rendered":"Descobreixen un compost que podria canviar el tractament de les lesions cerebrals traum\u00e0tiques"},"content":{"rendered":"<p>Un equip internacional de cient\u00edfics, amb la participaci\u00f3 de <a href=\"https:\/\/www.iqac.csic.es\/\" target=\"_blank\" rel=\"noopener\">l\u2019Institut de Qu\u00edmica Avan\u00e7ada de Catalunya (IQAC)<\/a> del <a href=\"https:\/\/www.csic.es\/es\" target=\"_blank\" rel=\"noopener\">Consell Superior d\u2019Investigacions Cient\u00edfiques (CSIC)<\/a>, organisme adscrit al Ministeri de Ci\u00e8ncia, Innovaci\u00f3 i Universitats, ha descobert que un compost de petita mida \u2014un p\u00e8ptid format per quatre amino\u00e0cids\u2014, anomenat CAQK, t\u00e9 un efecte neuroprotector significatiu en models animals de traumatisme cranioencef\u00e0lic.<\/p>\n<p>Administrat poc despr\u00e9s de la lesi\u00f3 per via intravenosa en models animals (ratol\u00ed i porc), el CAQK es dirigeix espec\u00edficament a les zones danyades del cervell, atret per una prote\u00efna que \u00e9s present en major quantitat a les zones lesionades despr\u00e9s d\u2019un traumatisme. El CAQK s\u2019acumula a la zona marcada per la prote\u00efna i aconsegueix reduir la inflamaci\u00f3, la mort cel\u00b7lular i el dany en el teixit cerebral. A m\u00e9s, ha demostrat millorar la recuperaci\u00f3 funcional sense mostrar toxicitat aparent en ratolins. Els resultats, publicats a la revista <em>EMBO Molecular Medicine<\/em>, obren noves possibilitats per tractar zones lesionades del cervell.<\/p>\n<p>L\u2019estudi est\u00e0 liderat per la companyia <a href=\"https:\/\/www.aivocode.com\/\" target=\"_blank\" rel=\"noopener\">Aivocode<\/a> (spin-off de <a href=\"https:\/\/sbpdiscovery.org\/\" target=\"_blank\" rel=\"noopener\">l\u2019Institut Sanford Burnham Prebys<\/a>) de San Diego (Calif\u00f2rnia), en col\u00b7laboraci\u00f3 amb l\u2019Institut de Qu\u00edmica Avan\u00e7ada de Catalunya (IQAC) del CSIC i la <a href=\"https:\/\/www.ucdavis.edu\/\" target=\"_blank\" rel=\"noopener\">Universitat de Calif\u00f2rnia Davis<\/a>.<\/p>\n<p>L\u2019empresa Aivocode, fundada pels investigadors Aman P. Mann, Sazid Hussain i Erkki Ruoslahti (autors de l\u2019estudi), t\u00e9 previst sol\u00b7licitar properament a la FDA (l\u2019ag\u00e8ncia reguladora dels Estats Units) l\u2019autoritzaci\u00f3 per iniciar els assajos cl\u00ednics en humans. Encara que no hi ha una data concreta, el fet que es tracti d\u2019un p\u00e8ptid curt, f\u00e0cil de produir i amb bona penetraci\u00f3 als teixits en facilita el desenvolupament com a f\u00e0rmac.<\/p>\n<h5><strong>Traumatisme cranioencef\u00e0lic<\/strong><\/h5>\n<p>El traumatisme cranioencef\u00e0lic \u00e9s una lesi\u00f3 cerebral causada habitualment per cops al cap, com accidents de tr\u00e0nsit, laborals o caigudes. S\u2019estima que afecta unes 200 persones per cada 100.000 habitants a l\u2019any. Actualment, el tractament se centra a estabilitzar el pacient, reduint la pressi\u00f3 intracranial i mantenint el flux sanguini, per\u00f2 no existeixen f\u00e0rmacs aprovats per aturar el dany cerebral ni els seus efectes secundaris, com la inflamaci\u00f3 o la mort cel\u00b7lular. A m\u00e9s, les ter\u00e0pies que s\u2019estan investigant requereixen injeccions directes al cervell, una t\u00e8cnica invasiva que pot causar complicacions.<\/p>\n<blockquote><p>\u201cLes intervencions actuals per tractar la lesi\u00f3 cerebral aguda tenen com a objectiu estabilitzar el pacient reduint la pressi\u00f3 intracranial i mantenint el flux sanguini, per\u00f2 no existeixen f\u00e0rmacs aprovats per aturar els danys i els efectes secundaris d\u2019aquestes lesions\u201d, explica el <strong>Dr. Pablo Scodeller<\/strong>, investigador de l\u2019IQAC-CSIC i coautor de l\u2019estudi.<\/p><\/blockquote>\n<h5><strong>El gran repte de la neurolog\u00eda<\/strong><\/h5>\n<p>Trobar una manera de tractar el cervell lesionat de manera no invasiva \u00e9s un dels grans reptes de la neurologia. I aquest treball va en aquesta l\u00ednia, basant-se en un altre dut a terme pels investigadors el 2016, publicat a <a href=\"https:\/\/www.nature.com\/articles\/ncomms11980\" target=\"_blank\" rel=\"noopener\">Nature Communications<\/a>.<\/p>\n<p>Llavors, l\u2019investigador Aman P. Mann, juntament amb Pablo Scodeller, treballant al laboratori del Dr. Ruoslahti (autor senior principal d\u2019ambd\u00f3s estudis) a Sanford Burnham Prebys, van descobrir un p\u00e8ptid \u2014una petita cadena d\u2019amino\u00e0cids, els components b\u00e0sics de les prote\u00efnes\u2014 que es dirigia de manera espec\u00edfica a les zones lesionades del cervell en ratolins. El p\u00e8ptid CAQK va ser identificat mitjan\u00e7ant una t\u00e8cnica de cribatge massiu (<em>peptide-phage display<\/em>) que permet seleccionar mol\u00e8cules amb afinitat per teixits concrets. En aquell estudi, el CAQK es va utilitzar com a \u201cvehicle\u201d per transportar f\u00e0rmacs a la zona danyada. No obstant aix\u00f2, en el nou treball els investigadors han anat un pas m\u00e9s enll\u00e0 i han comprovat que el p\u00e8ptid CAQK per si sol t\u00e9 efectes terap\u00e8utics.<\/p>\n<p>Per avaluar la seva activitat terap\u00e8utica, primer es va administrar per via intravenosa poc despr\u00e9s d\u2019un traumatisme cranioencef\u00e0lic moderat o greu i es va observar que el p\u00e8ptid s\u2019acumulava al cervell lesionat de ratolins i porcs (aquests \u00faltims tenen un cervell m\u00e9s semblant al de l\u2019\u00e9sser hum\u00e0 que els ratolins). A m\u00e9s, es va comprovar que el p\u00e8ptid s\u2019unia a unes mol\u00e8cules especials anomenades glicoprote\u00efnes (prote\u00efnes amb sucres units), que es tornen m\u00e9s abundants despr\u00e9s d\u2019una lesi\u00f3 i formen part de la matriu extracel\u00b7lular (una xarxa de suport que envolta les c\u00e8l\u00b7lules del cervell).<\/p>\n<p>El tractament de ratolins amb traumatisme cranioencef\u00e0lic amb aquest p\u00e8ptid va resultar en una reducci\u00f3 de la mida de la lesi\u00f3 en comparaci\u00f3 amb els ratolins control. \u201cEs va observar menor mort cel\u00b7lular i menys expressi\u00f3 de marcadors d\u2019inflamaci\u00f3 a la zona lesionada, la qual cosa indicava que el CAQK alleujava la neuroinflamaci\u00f3 i els efectes secundaris conseq\u00fcents. Tamb\u00e9 es van fer proves de comportament i mem\u00f2ria en ratolins despr\u00e9s del tractament, observant una millora en el d\u00e8ficit funcional, sense toxicitat evident\u201d, explica el primer autor de l\u2019estudi, <strong>Dr. Mann<\/strong>.<\/p>\n<p>Els resultats de l\u2019estudi evidencien que el p\u00e8ptid CAQK pot reparar la zona danyada, demostrant aix\u00ed les potencials aplicacions terap\u00e8utiques despr\u00e9s d\u2019un traumatisme. \u201cEl m\u00e9s emocionant \u00e9s que, a m\u00e9s de demostrar ser molt efectiu, es tracta d\u2019un compost molt senzill: un p\u00e8ptid curt i f\u00e0cil de produir de manera segura a gran escala. Els p\u00e8ptids d\u2019aquestes caracter\u00edstiques tenen una bona penetraci\u00f3 als teixits i no s\u00f3n immunog\u00e8nics\u201d, conclou <strong>Scodeller<\/strong>.<\/p>\n<p>&nbsp;<\/p>\n<p style=\"font-size: 75%;\">Mann AP, Hussain S, Scodeller P, Moore HNB, Sherazee E, Russo RM, Ruoslahti E. <strong>A neuroprotective tetrapeptide for treatment of acute traumatic brain injury<\/strong>. EMBO Mol Med. 2025 doi: <a href=\"https:\/\/www.embopress.org\/doi\/full\/10.1038\/s44321-025-00312-5\" target=\"_blank\" rel=\"noopener\">10.1038\/s44321-025-00312-5<\/a><\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Un equip internacional de cient\u00edfics, amb la participaci\u00f3 de l\u2019Institut de Qu\u00edmica Avan\u00e7ada de Catalunya (IQAC) del Consell Superior d\u2019Investigacions Cient\u00edfiques (CSIC), organisme adscrit al Ministeri de Ci\u00e8ncia, Innovaci\u00f3 i Universitats, ha descobert que un compost de petita mida \u2014un p\u00e8ptid format per quatre amino\u00e0cids\u2014, anomenat CAQK, t\u00e9 un efecte neuroprotector significatiu en models animals<a class=\"more-link\" href=\"https:\/\/www.iqac.csic.es\/ca\/descobreixen-un-compost-que-podria-canviar-el-tractament-de-les-lesions-cerebrals-traumatiques\/\">Continue reading <span class=\"screen-reader-text\">\u00abDescobreixen un compost que podria canviar el tractament de les lesions cerebrals traum\u00e0tiques\u00bb<\/span><\/a><\/p>\n","protected":false},"author":3,"featured_media":4558,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[73],"tags":[],"class_list":["post-8330","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news","entry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.7 - 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