{"id":8354,"date":"2026-02-26T11:55:36","date_gmt":"2026-02-26T10:55:36","guid":{"rendered":"https:\/\/www.iqac.csic.es\/el-csic-crea-un-anticos-que-protegeix-in-vitro-les-cel%c2%b7lules-del-sistema-immunitari-dun-bacteri-hospitalari-perillos\/"},"modified":"2026-06-16T10:47:40","modified_gmt":"2026-06-16T08:47:40","slug":"el-csic-crea-un-anticos-que-protegeix-in-vitro-les-cel%c2%b7lules-del-sistema-immunitari-dun-bacteri-hospitalari-perillos","status":"publish","type":"post","link":"https:\/\/www.iqac.csic.es\/ca\/el-csic-crea-un-anticos-que-protegeix-in-vitro-les-cel%c2%b7lules-del-sistema-immunitari-dun-bacteri-hospitalari-perillos\/","title":{"rendered":"El CSIC crea un antic\u00f2s que protegeix in vitro les c\u00e8l\u00b7lules del sistema immunitari d\u2019un bacteri hospitalari perill\u00f3s"},"content":{"rendered":"<p>Un antic\u00f2s monoclonal creat pel grup de <a href=\"https:\/\/www.iqac.csic.es\/research\/departments\/surfactants-and-nanobiotechnology\/nanobiotecnology-for-diagnostics\/\" target=\"_blank\" rel=\"noopener\">Nanobiotecnologia per al Diagn\u00f2stic<\/a> (Nb4D) de <a href=\"https:\/\/www.iqac.csic.es\/\" target=\"_blank\" rel=\"noopener\">l\u2019Institut de Qu\u00edmica Avan\u00e7ada de Catalunya<\/a> (IQAC), del <a href=\"https:\/\/www.csic.es\/es\" target=\"_blank\" rel=\"noopener\">Consell Superior d\u2019Investigacions Cient\u00edfiques<\/a> (CSIC), ha demostrat en cultius cel\u00b7lulars que pot neutralitzar la toxina piocianina del bacteri <em>Pseudomonas aeruginosa<\/em>, considerada per l\u2019Organitzaci\u00f3 Mundial de la Salut molt perillosa per la seva elevada resist\u00e8ncia a gaireb\u00e9 tots els antibi\u00f2tics i per la seva pres\u00e8ncia als hospitals.<\/p>\n<p>En aquest treball, publicat a la revista <em>ACS Pharmacology and Translational Science<\/em>, s\u2019ha seguit una estrat\u00e8gia \u201cantivirul\u00e8ncia\u201d, que no va dirigida contra el bacteri, com els tractaments actuals, sin\u00f3 que se centra a inhibir la toxina piocianina, amb el valor afegit que aquest enfocament no provocaria resist\u00e8ncia als antibi\u00f2tics.<\/p>\n<p><em>Pseudomonas aeruginosa<\/em> \u00e9s considerada un dels pat\u00f2gens m\u00e9s preocupants a escala global per la seva capacitat d\u2019adaptar-se i desenvolupar resist\u00e8ncia a la majoria dels antibi\u00f2tics disponibles, fet que provoca milers de morts anuals en pacients vulnerables. La seva toxina, la piocianina, exerceix un paper decisiu en aquesta capacitat nociva, ja que destrueix c\u00e8l\u00b7lules del sistema immunitari i altera la resposta inflamat\u00f2ria de l\u2019organisme. Neutralitzar aquesta toxina constitueix una via terap\u00e8utica alternativa amb potencial per reduir la necessitat d\u2019antibi\u00f2tics i el risc d\u2019aparici\u00f3 de noves resist\u00e8ncies.<\/p>\n<blockquote><p>La investigadora de l\u2019IQAC i autora de l\u2019estudi, <strong>Llu\u00efsa Vilaplana<\/strong>, subratlla la urg\u00e8ncia de buscar tractaments innovadors davant aquest tipus de bacteris. \u00abAquest bacteri, a causa de la seva elevada adaptabilitat, ha desenvolupat una gran resist\u00e8ncia als antibi\u00f2tics cl\u00e0ssics, fet que ha impulsat el desenvolupament de noves estrat\u00e8gies terap\u00e8utiques per reduir les soques multiresistents i minimitzar la progressi\u00f3 de la infecci\u00f3\u00bb, explica. Aquesta resist\u00e8ncia extrema converteix la recerca d\u2019alternatives en un repte prioritari.<\/p><\/blockquote>\n<h4><strong>Antic\u00f2s monoclonal<\/strong><\/h4>\n<p>Amb aquest objectiu, les investigadores de l\u2019IQAC van desenvolupar en models de ratol\u00ed un antic\u00f2s monoclonal anomenat mAb122, dissenyat per unir-se espec\u00edficament a la piocianina i impedir-ne l\u2019acci\u00f3. Un antic\u00f2s monoclonal \u00e9s una prote\u00efna generada al laboratori que reconeix de manera molt precisa una \u00fanica mol\u00e8cula, cosa que permet bloquejar-ne selectivament l\u2019efecte.<\/p>\n<p>Despr\u00e9s de la seva producci\u00f3, l\u2019antic\u00f2s es va avaluar en macr\u00f2fags exposats a diferents concentracions de la toxina. Els resultats van mostrar que el mAb122 redueix el dany cel\u00b7lular provocat per la piocianina i augmenta notablement la superviv\u00e8ncia de les c\u00e8l\u00b7lules immunit\u00e0ries. A m\u00e9s, quan es va administrar sol, no va mostrar efectes t\u00f2xics, un aspecte essencial per considerar-ne el desenvolupament en fases posteriors.<\/p>\n<p>La investigadora de l\u2019IQAC <strong>Pilar Marco<\/strong>, responsable del grup de Nanobiotecnologia per al Diagn\u00f2stic, que ha liderat la recerca, destaca el potencial d\u2019aquesta aproximaci\u00f3 terap\u00e8utica. \u00abA difer\u00e8ncia dels antibi\u00f2tics convencionals, aquesta estrat\u00e8gia no pret\u00e9n eliminar directament el microorganisme, sin\u00f3 neutralitzar un dels seus principals mecanismes de virul\u00e8ncia. Amb aquest tipus de ter\u00e0pies antivirul\u00e8ncia s\u2019aconsegueix reduir la pressi\u00f3 selectiva que afavoreix l\u2019aparici\u00f3 de resist\u00e8ncies\u00bb. Aquesta forma d\u2019intervenci\u00f3 busca desarmar el bacteri en lloc de matar-lo, cosa que disminueix la probabilitat que apareguin mutacions de resist\u00e8ncia als antibi\u00f2tics.<\/p>\n<p>L\u2019estudi proposa un enfocament terap\u00e8utic innovador i prometedor, orientat a minimitzar l\u2019\u00fas d\u2019antibi\u00f2tics i permetre\u2019n l\u2019administraci\u00f3 en dosis m\u00e9s baixes. En no actuar sobre la viabilitat bacteriana, sin\u00f3 sobre un dels seus principals mecanismes de virul\u00e8ncia, l\u2019antic\u00f2s no exerceix pressi\u00f3 selectiva, fet que redueix la probabilitat d\u2019aparici\u00f3 de noves resist\u00e8ncies.<\/p>\n<p>L\u2019estudi tamb\u00e9 va analitzar com afectava l\u2019antic\u00f2s la resposta inflamat\u00f2ria, ja que la piocianina altera la producci\u00f3 de diverses citocines implicades en la regulaci\u00f3 immunit\u00e0ria. Tot i que l\u2019antic\u00f2s va modificar alguns d\u2019aquests nivells, els resultats indiquen que caldr\u00e0 estudiar m\u00e9s a fons el seu impacte sobre la inflamaci\u00f3 i determinar si \u00e9s possible modular-la adequadament en futures fases de la recerca.<\/p>\n<p>La neutralitzaci\u00f3 de la piocianina mitjan\u00e7ant anticossos representa, aix\u00ed, una estrat\u00e8gia prometedora per protegir a nivell cel\u00b7lular les c\u00e8l\u00b7lules defensives de l\u2019organisme davant d\u2019un dels principals elements de virul\u00e8ncia de <em>Pseudomonas aeruginosa<\/em>. Aquest enfocament no busca eliminar el bacteri, sin\u00f3 disminuir-ne la capacitat de causar dany i facilitar l\u2019acci\u00f3 del sistema immunitari, fet que podria ser determinant per frenar infeccions greus sense incrementar l\u2019\u00fas d\u2019antibi\u00f2tics.<\/p>\n<p>Tot i que el treball es troba en una fase inicial, els resultats <em>in vitro<\/em> obren la porta a futurs estudis <em>in vivo<\/em>, necessaris per valorar-ne la seguretat i l\u2019efic\u00e0cia en organismes complets. Si aquestes investigacions confirmen les dades obtingudes, aquesta aproximaci\u00f3 podria convertir-se en una eina terap\u00e8utica m\u00e9s espec\u00edfica i segura per combatre infeccions provocades per bacteris multiresistents, especialment en entorns hospitalaris. El pas seg\u00fcent ser\u00e0 avaluar-ne l\u2019efecte protector en models animals i determinar si es poden evitar respostes inflamat\u00f2ries no desitjades.<\/p>\n<p>&nbsp;<\/p>\n<p style=\"font-size: 75%;\">Rodr\u00edguez-Urretavizcaya, B., Posvai, T., Vilaplana, Ll. and Marco, M.P. <strong>Anti-pyocyanin Antibody Exhibits Cytotoxicity Protective Effects on Macrophages: A Promising Innovative Therapeutic Approach for Pseudomonas aeruginosa Infections<\/strong>. ACS Pharmacol. Transl. Sci (2025) <a href=\"https:\/\/doi.org\/10.1021\/acsptsci.5c00187\" target=\"_blank\" rel=\"noopener\">https:\/\/doi.org\/10.1021\/acsptsci.5c00187<\/a><\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Un antic\u00f2s monoclonal creat pel grup de Nanobiotecnologia per al Diagn\u00f2stic (Nb4D) de l\u2019Institut de Qu\u00edmica Avan\u00e7ada de Catalunya (IQAC), del Consell Superior d\u2019Investigacions Cient\u00edfiques (CSIC), ha demostrat en cultius cel\u00b7lulars que pot neutralitzar la toxina piocianina del bacteri Pseudomonas aeruginosa, considerada per l\u2019Organitzaci\u00f3 Mundial de la Salut molt perillosa per la seva elevada resist\u00e8ncia<a class=\"more-link\" href=\"https:\/\/www.iqac.csic.es\/ca\/el-csic-crea-un-anticos-que-protegeix-in-vitro-les-cel%c2%b7lules-del-sistema-immunitari-dun-bacteri-hospitalari-perillos\/\">Continue reading <span class=\"screen-reader-text\">\u00abEl CSIC crea un antic\u00f2s que protegeix in vitro les c\u00e8l\u00b7lules del sistema immunitari d\u2019un bacteri hospitalari perill\u00f3s\u00bb<\/span><\/a><\/p>\n","protected":false},"author":3,"featured_media":4587,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[73],"tags":[],"class_list":["post-8354","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news","entry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.7 - 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