{"id":8363,"date":"2026-05-11T08:03:37","date_gmt":"2026-05-11T06:03:37","guid":{"rendered":"https:\/\/www.iqac.csic.es\/desxifrant-la-comunicacio-entre-cel%c2%b7lules-canceroses-per-millorar-el-tractament-del-cancer-de-pancrees\/"},"modified":"2026-06-16T10:47:44","modified_gmt":"2026-06-16T08:47:44","slug":"desxifrant-la-comunicacio-entre-cel%c2%b7lules-canceroses-per-millorar-el-tractament-del-cancer-de-pancrees","status":"publish","type":"post","link":"https:\/\/www.iqac.csic.es\/ca\/desxifrant-la-comunicacio-entre-cel%c2%b7lules-canceroses-per-millorar-el-tractament-del-cancer-de-pancrees\/","title":{"rendered":"Desxifrant la comunicaci\u00f3 entre c\u00e8l\u00b7lules canceroses per millorar el tractament del c\u00e0ncer de p\u00e0ncrees"},"content":{"rendered":"<p><strong>Les c\u00e8l\u00b7lules canceroses no actuen soles. Mitjan\u00e7ant complexes xarxes de comunicaci\u00f3 i vies de senyalitzaci\u00f3, les c\u00e8l\u00b7lules tumorals i el seu microambient coordinen respostes adaptatives que impulsen la resist\u00e8ncia als f\u00e0rmacs. Comprendre aquestes interaccions \u00e9s clau per millorar el tractament del c\u00e0ncer.<\/strong><\/p>\n<p>Els tumors s\u00f3n sistemes multicel\u00b7lulars din\u00e0mics en qu\u00e8 les c\u00e8l\u00b7lules canceroses es comuniquen cont\u00ednuament amb les c\u00e8l\u00b7lules estromals i immunit\u00e0ries del seu entorn. Aquesta comunicaci\u00f3 intercel\u00b7lular modela l\u2019evoluci\u00f3 tumoral, afavoreix la resist\u00e8ncia a les ter\u00e0pies i limita l\u2019efic\u00e0cia dels tractaments (Hanahan i Weinberg, 2011; Meads et al., 2009). Mitjan\u00e7ant l\u2019estudi de vies de senyalitzaci\u00f3 i interactomes en models avan\u00e7ats d\u2019organoides de c\u00e0ncer de p\u00e0ncrees, <a href=\"https:\/\/www.cancerscanproject.eu\/\" target=\"_blank\" rel=\"noopener\"><strong>CancerScan<\/strong><\/a> pret\u00e9n descobrir mecanismes de resist\u00e8ncia que es puguin aprofitar per millorar estrat\u00e8gies terap\u00e8utiques personalitzades per a cada pacient.<\/p>\n<p>La progressi\u00f3 del c\u00e0ncer i la resposta a la ter\u00e0pia no estan determinades \u00fanicament per alteracions gen\u00e8tiques dins de les c\u00e8l\u00b7lules tumorals. M\u00e9s aviat, emergeixen d\u2019una complexa xarxa d\u2019interaccions entre les c\u00e8l\u00b7lules canceroses i el seu microambient, conegut com a microambient tumoral (TME). Aquestes interaccions depenen d\u2019una comunicaci\u00f3 coordinada entre c\u00e8l\u00b7lules mediada per factors solubles, contacte cel\u00b7lular directe i ves\u00edcules extracel\u00b7lulars (EVs), que conjuntament configuren el comportament i l\u2019adaptabilitat del tumor (Dagogo-Jack i Shaw, 2018; Truong i Pauklin, 2021).<\/p>\n<p>En c\u00e0ncers altament agressius com l\u2019adenocarcinoma ductal pancre\u00e0tic (PDAC), aquesta xarxa de comunicaci\u00f3 t\u00e9 un paper especialment cr\u00edtic. Components estromals densos, infiltrats immunitaris i matrius extracel\u00b7lulars alterades creen un microambient que afavoreix activament la superviv\u00e8ncia tumoral i confereix resist\u00e8ncia a la quimioter\u00e0pia (Meads et al., 2009; Truong i Pauklin, 2021). Com a resultat, fins i tot tractaments que ataquen efica\u00e7ment les c\u00e8l\u00b7lules canceroses en models in vitro simplificats sovint fracassen en pacients.<\/p>\n<h4><strong>La comunicaci\u00f3 cel\u00b7lular com a motor de la resist\u00e8ncia als f\u00e0rmacs<\/strong><\/h4>\n<p>La comunicaci\u00f3 entre c\u00e8l\u00b7lules permet a les c\u00e8l\u00b7lules tumorals detectar i respondre a l\u2019estr\u00e8s ambiental, inclosa la pressi\u00f3 terap\u00e8utica. Els senyals intercanviats entre c\u00e8l\u00b7lules canceroses i c\u00e8l\u00b7lules estromals o immunit\u00e0ries poden activar vies de superviv\u00e8ncia, induir plasticitat fenot\u00edpica i promoure l\u2019aparici\u00f3 d\u2019estats cel\u00b7lulars tolerants als f\u00e0rmacs. Actualment, aquestes respostes adaptatives es reconeixen com a grans contribuents a la malaltia residual m\u00ednima i a la recaiguda tumoral (Dagogo-Jack i Shaw, 2018).<\/p>\n<p>Les ves\u00edcules extracel\u00b7lulars han emergit com a mediadors clau d\u2019aquesta comunicaci\u00f3. Mitjan\u00e7ant la transfer\u00e8ncia de prote\u00efnes, \u00e0cids nucleics i metab\u00f2lits entre c\u00e8l\u00b7lules, les EVs permeten una r\u00e0pida reprogramaci\u00f3 tant de c\u00e8l\u00b7lules canceroses com no canceroses. En el c\u00e0ncer de p\u00e0ncrees, s\u2019ha demostrat que la senyalitzaci\u00f3 mediada per EVs modula la immunosupressi\u00f3, promou la transici\u00f3 epiteli-mes\u00e8nquima i augmenta la resist\u00e8ncia a agents quimioterap\u00e8utics (Boelens et al., 2014; Binenbaum et al., 2018; Becker et al., 2016).<\/p>\n<h4><strong>Cartografiant vies de senyalitzaci\u00f3 mitjan\u00e7ant interactomes basats en organoides<\/strong><\/h4>\n<p>Per desentrellar aquestes complexes xarxes de comunicaci\u00f3, CancerScan es basa en models avan\u00e7ats d\u2019organoides tumorals que conserven caracter\u00edstiques clau del microambient tumoral. Combinant c\u00e8l\u00b7lules de c\u00e0ncer de p\u00e0ncrees amb components estromals i immunitaris rellevants, aquests models permeten investigar sistem\u00e0ticament les vies de senyalitzaci\u00f3 sota condicions de tractament controlades que reflecteixen millor els tumors dels pacients.<\/p>\n<p>Dins de CancerScan, l\u2019IQAC-CSIC contribueix caracteritzant l\u2019interactoma molecular que emergeix entre diferents poblacions cel\u00b7lulars dins dels organoides de c\u00e0ncer de p\u00e0ncrees, tant abans com despr\u00e9s del tractament amb agents quimioterap\u00e8utics cl\u00ednicament rellevants. Mitjan\u00e7ant aproximacions basades en prote\u00f2mica, inclosa l\u2019an\u00e0lisi de prote\u00efnes derivades de c\u00e8l\u00b7lules i associades a EVs, el CSIC investiga com es reorganitzen les xarxes de comunicaci\u00f3 intercel\u00b7lular en resposta a la ter\u00e0pia. Comparar organoides exposats a diferents f\u00e0rmacs permet identificar vies de comunicaci\u00f3 i nodes d\u2019interacci\u00f3 proteica associats a sensibilitat o resist\u00e8ncia diferencial als tractaments.<\/p>\n<p>Integrant dades prote\u00f2miques de l\u2019interactoma amb lectures funcionals de resposta als f\u00e0rmacs, aquest enfocament va m\u00e9s enll\u00e0 de l\u2019an\u00e0lisi d\u2019una sola via. En canvi, captura la resist\u00e8ncia com un fenomen a escala de xarxa impulsat per adaptacions coordinades entre m\u00faltiples tipus cel\u00b7lulars (Hanahan i Weinberg, 2011; Meads et al., 2009).<\/p>\n<h4><strong>De les xarxes de comunicaci\u00f3 a les estrat\u00e8gies de tractament personalitzat<\/strong><\/h4>\n<p>Comprendre la resist\u00e8ncia als f\u00e0rmacs en c\u00e0ncer requereix estudiar els tumors com a sistemes comunicatius i no com a c\u00e8l\u00b7lules a\u00efllades. Integrant experiments basats en organoides amb an\u00e0lisis exhaustives de senyalitzaci\u00f3 i interactomes, CancerScan busca descobrir com la comunicaci\u00f3 cel\u00b7lular impulsa la resist\u00e8ncia als tractaments en el c\u00e0ncer de p\u00e0ncrees.<\/p>\n<p>Aquest coneixement proporciona una base mecan\u00edstica per construir bessons digitals tumorals biol\u00f2gicament realistes i desenvolupar estrat\u00e8gies terap\u00e8utiques personalitzades capaces d\u2019anticipar i contrarestar respostes adaptatives del tumor. En \u00faltima inst\u00e0ncia, desxifrar les xarxes de comunicaci\u00f3 del c\u00e0ncer ofereix una via cap a ter\u00e0pies m\u00e9s eficaces i duradores per als pacients.<\/p>\n<p style=\"font-size: 75%;\"><strong>Refer\u00e8ncies<\/strong><\/p>\n<p style=\"font-size: 75%;\">Becker, A. et al. (2016). Extracellular vesicles in cancer: Cell-to-cell mediators of metastasis.\u00a0<em>Cancer Cell<\/em>, 30(6), 836\u2013848.<\/p>\n<p style=\"font-size: 75%;\">Binenbaum, Y. et al. (2018). Transfer of miRNA in macrophage-derived exosomes induces drug resistance in pancreatic adenocarcinoma. Cancer Research, 78(18), pp. 5287\u20135299.<\/p>\n<p style=\"font-size: 75%;\">Boelens, M.C. et al. (2014). Exosome transfer from stromal to breast cancer cells regulates therapy resistance pathways. Cell, 159(3), pp. 499\u2013513.<\/p>\n<p style=\"font-size: 75%;\">Dagogo-Jack, I. and Shaw, A.T. (2018). Tumour heterogeneity and resistance to cancer therapies. Nature Reviews Clinical Oncology, 15(2), pp. 81\u201394.<\/p>\n<p style=\"font-size: 75%;\">Drost, J. and Clevers, H. (2018). Organoids in cancer research.\u00a0<em>Nature Reviews Cancer<\/em>, 18(7), pp. 407\u2013418.<\/p>\n<p style=\"font-size: 75%;\">Hanahan, D. and Weinberg, R.A. (2011). Hallmarks of cancer: the next generation. Cell, 144(5), pp. 646\u2013674.<\/p>\n<p style=\"font-size: 75%;\">Meads, M.B., Gatenby, R.A. and Dalton, W.S. (2009). Environment-mediated drug resistance: a major contributor to minimal residual disease. Nature Reviews Cancer, 9(9), pp. 665\u2013674.<\/p>\n<p style=\"font-size: 75%;\">Truong, L.H. and Pauklin, S. (2021). Pancreatic cancer microenvironment and cellular composition: current understandings and therapeutic approaches. Cancers, 13(19), 5028.<\/p>\n<p>&nbsp;<\/p>\n<p style=\"text-align: right;\"><strong>Comunicaci\u00f3 Projecte CancerScan<\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Les c\u00e8l\u00b7lules canceroses no actuen soles. Mitjan\u00e7ant complexes xarxes de comunicaci\u00f3 i vies de senyalitzaci\u00f3, les c\u00e8l\u00b7lules tumorals i el seu microambient coordinen respostes adaptatives que impulsen la resist\u00e8ncia als f\u00e0rmacs. Comprendre aquestes interaccions \u00e9s clau per millorar el tractament del c\u00e0ncer. Els tumors s\u00f3n sistemes multicel\u00b7lulars din\u00e0mics en qu\u00e8 les c\u00e8l\u00b7lules canceroses es comuniquen<a class=\"more-link\" href=\"https:\/\/www.iqac.csic.es\/ca\/desxifrant-la-comunicacio-entre-cel%c2%b7lules-canceroses-per-millorar-el-tractament-del-cancer-de-pancrees\/\">Continue reading <span class=\"screen-reader-text\">\u00abDesxifrant la comunicaci\u00f3 entre c\u00e8l\u00b7lules canceroses per millorar el tractament del c\u00e0ncer de p\u00e0ncrees\u00bb<\/span><\/a><\/p>\n","protected":false},"author":3,"featured_media":4597,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[73],"tags":[],"class_list":["post-8363","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news","entry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.7 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Desxifrant la comunicaci\u00f3 entre c\u00e8l\u00b7lules canceroses per millorar el tractament del c\u00e0ncer de p\u00e0ncrees | IQAC - Institut de Qu\u00edmica Avan\u00e7ada de Catalunya - CSIC<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.iqac.csic.es\/ca\/desxifrant-la-comunicacio-entre-cel\u00b7lules-canceroses-per-millorar-el-tractament-del-cancer-de-pancrees\/\" \/>\n<meta property=\"og:locale\" content=\"ca_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Desxifrant la comunicaci\u00f3 entre c\u00e8l\u00b7lules canceroses per millorar el tractament del c\u00e0ncer de p\u00e0ncrees | IQAC - Institut de Qu\u00edmica Avan\u00e7ada de Catalunya - CSIC\" \/>\n<meta property=\"og:description\" content=\"Les c\u00e8l\u00b7lules canceroses no actuen soles. 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