{"id":8367,"date":"2026-05-29T07:30:12","date_gmt":"2026-05-29T05:30:12","guid":{"rendered":"https:\/\/www.iqac.csic.es\/una-nova-mirada-a-lalliberament-de-proteines-encapsulades-en-nanoparticules\/"},"modified":"2026-06-16T10:47:44","modified_gmt":"2026-06-16T08:47:44","slug":"una-nova-mirada-a-lalliberament-de-proteines-encapsulades-en-nanoparticules","status":"publish","type":"post","link":"https:\/\/www.iqac.csic.es\/ca\/una-nova-mirada-a-lalliberament-de-proteines-encapsulades-en-nanoparticules\/","title":{"rendered":"Una nova mirada a l\u2019alliberament de prote\u00efnes encapsulades en nanopart\u00edcules"},"content":{"rendered":"

La medicina de precisi\u00f3 busca transportar agents terap\u00e8utics, com mol\u00e8cules, prote\u00efnes o ARN, fins al lloc exacte on han d\u2019actuar dins del cos. Una de les estrat\u00e8gies m\u00e9s prometedores \u00e9s l\u2019\u00fas de nanotransportadors: nanopart\u00edcules capaces d\u2019encapsular el f\u00e0rmac, protegir-lo, transportar-lo i alliberar-lo de manera controlada on sigui necessari. Actualment, per\u00f2, el seu comportament s\u2019analitza habitualment mitjan\u00e7ant t\u00e8cniques basades en mesures mitjanes de grans poblacions, fet que amaga les difer\u00e8ncies entre part\u00edcules individuals.<\/p>\n

Ara, un equip liderat per l\u2019Institut de Ci\u00e8ncia de Materials de Barcelona (ICMAB-CSIC)<\/strong>, en col\u00b7laboraci\u00f3 amb l\u2019Institut de Qu\u00edmica Avan\u00e7ada de Catalunya (IQAC)<\/strong> i la Universitat de Parma<\/strong>, ha demostrat que \u00e9s possible fer un seguiment part\u00edcula a part\u00edcula del proc\u00e9s d\u2019alliberament. \u201cDins d\u2019una mateixa poblaci\u00f3 el comportament no \u00e9s homogeni: algunes
\nnanopart\u00edcules alliberen la c\u00e0rrega molt r\u00e0pidament, d\u2019altres m\u00e9s lentament, i algunes gaireb\u00e9 no l\u2019alliberen. Si nom\u00e9s analitzem la mitjana, aquests extrems queden amagats\u201d, expliquen les investigadores Anna Sol\u00e9<\/strong> i Anna Roig<\/strong>. L\u2019estudi s\u2019ha publicat a la revista Nanoscale Horizons en co-lideratge amb la S\u00edlvia Pujals<\/strong> de l\u2019IQAC.<\/p>\n

Un seguiment part\u00edcula a part\u00edcula<\/h4>\n

L\u2019equip ha treballat amb nanotransportadors basats en un pol\u00edmer biodegradable anomenat PLGA, \u00e0mpliament utilitzat en aplicacions m\u00e8diques. Aquest material pot encapsular diferents tipus de biomol\u00e8cules, com prote\u00efnes o ARN. En aquest estudi s\u2019ha encapsulat una prote\u00efna com\u00fa anomenada alb\u00famina, la qual ha servit com a model de f\u00e0rmac. En el futur, per\u00f2, es podria treballar amb altres biomol\u00e8cules terap\u00e8utiques amb objectius m\u00e8dics reals. Les t\u00e8cniques convencionals per estudiar l\u2019alliberament de la c\u00e0rrega requereixen manipular les mostres i ofereixen nom\u00e9s informaci\u00f3 global, sense captar el comportament individual de cada nanopart\u00edcula.<\/p>\n

Per superar aquesta limitaci\u00f3, les investigadores han aplicat la t\u00e8cnica de microsc\u00f2pia anomenada dSTORM, que permet localitzar mol\u00e8cules fluorescents individuals amb alta precisi\u00f3. Mitjan\u00e7ant el marcatge fluorescent diferenciat del nanotransportador i de la prote\u00efna encapsulada, han pogut observar simult\u00e0niament ambd\u00f3s components i seguir la seva evoluci\u00f3 durant 30 dies.<\/p>\n

Aquest seguiment ha perm\u00e8s observar com es transforma cada nanopart\u00edcula i quantificar el ritme d\u2019alliberament de la prote\u00efna al llarg del temps. Els resultats mostren un alliberament inicial r\u00e0pid durant els primers dies, seguit d\u2019una fase m\u00e9s sostinguda fins a la degradaci\u00f3 final del pol\u00edmer. Paral\u00b7lelament, les nanopart\u00edcules experimenten un augment de di\u00e0metre i una disminuci\u00f3 en nombre, indicant processos d\u2019hidrataci\u00f3, inflament i degradaci\u00f3.<\/p>\n

Un dels resultats m\u00e9s rellevants \u00e9s la identificaci\u00f3 de grans difer\u00e8ncies entre nanopart\u00edcules individuals. Mentre algunes alliberen r\u00e0pidament una part important de la c\u00e0rrega, d\u2019altres en retenen la major part durant m\u00e9s temps. Aquestes difer\u00e8ncies, invisibles en els estudis basats en mitjanes, podrien tenir un paper determinant en l\u2019efic\u00e0cia terap\u00e8utica i en els possibles efectes adversos. \u201cCada vegada hi ha m\u00e9s evid\u00e8ncies que la resposta cl\u00ednica dep\u00e8n de quan, on i quanta c\u00e0rrega s\u2019allibera en cada part del cos\u201d, apunten les investigadores.<\/p>\n

Una nova eina al servei de la nanomedicina<\/h4>\n

Aquest nou enfocament obre la porta a una millor comprensi\u00f3 de la complexitat dels sistemes d\u2019alliberament de f\u00e0rmacs. \u201cObre dues vies de recerca\u201d, asseguren les investigadores: \u201cd\u2019una banda, la metodologia emprada en aquest estudi es podr\u00e0 aplicar a altres tipus de nanotransportadors; de l\u2019altra banda, proporciona una visi\u00f3 m\u00e9s acurada del comportament de les poblacions de nanopart\u00edcules, aportant informaci\u00f3 clau per optimitzar el disseny de futures ter\u00e0pies.\u201d<\/p>\n

 <\/p>\n

Sol\u00e9-Porta, A., Pujals, S., Delcanale, P., Roig, A.\u00a0 STORM as a tool to track cargo release from polymeric nanocarriers at the single-particle level. <\/strong>Nanoscale Horizons<\/em>, 2026. DOI: 10.1039\/d5nh00855g<\/a><\/p>\n

 <\/p>\n","protected":false},"excerpt":{"rendered":"

La medicina de precisi\u00f3 busca transportar agents terap\u00e8utics, com mol\u00e8cules, prote\u00efnes o ARN, fins al lloc exacte on han d\u2019actuar dins del cos. Una de les estrat\u00e8gies m\u00e9s prometedores \u00e9s l\u2019\u00fas de nanotransportadors: nanopart\u00edcules capaces d\u2019encapsular el f\u00e0rmac, protegir-lo, transportar-lo i alliberar-lo de manera controlada on sigui necessari. Actualment, per\u00f2, el seu comportament s\u2019analitza habitualmentContinue reading \u00abUna nova mirada a l\u2019alliberament de prote\u00efnes encapsulades en nanopart\u00edcules\u00bb<\/span><\/a><\/p>\n","protected":false},"author":3,"featured_media":4608,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[73],"tags":[],"class_list":["post-8367","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news","entry"],"acf":[],"yoast_head":"\nUna nova mirada a l\u2019alliberament de prote\u00efnes encapsulades en nanopart\u00edcules | IQAC - Institut de Qu\u00edmica Avan\u00e7ada de Catalunya - CSIC<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.iqac.csic.es\/una-nueva-mirada-a-la-liberacion-de-proteinas-encapsuladas-en-nanoparticulas\/\" \/>\n<meta property=\"og:locale\" content=\"ca_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Una nova mirada a l\u2019alliberament de prote\u00efnes encapsulades en nanopart\u00edcules | IQAC - Institut de Qu\u00edmica Avan\u00e7ada de Catalunya - CSIC\" \/>\n<meta property=\"og:description\" content=\"La medicina de precisi\u00f3 busca transportar agents terap\u00e8utics, com mol\u00e8cules, prote\u00efnes o ARN, fins al lloc exacte on han d\u2019actuar dins del cos. 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