{"id":8368,"date":"2026-06-01T07:24:30","date_gmt":"2026-06-01T05:24:30","guid":{"rendered":"https:\/\/www.iqac.csic.es\/desenvolupen-un-test-per-detectar-el-cancer-de-pancrees-en-minuts-amb-una-mostra-de-sang\/"},"modified":"2026-06-16T10:47:44","modified_gmt":"2026-06-16T08:47:44","slug":"desenvolupen-un-test-per-detectar-el-cancer-de-pancrees-en-minuts-amb-una-mostra-de-sang","status":"publish","type":"post","link":"https:\/\/www.iqac.csic.es\/ca\/desenvolupen-un-test-per-detectar-el-cancer-de-pancrees-en-minuts-amb-una-mostra-de-sang\/","title":{"rendered":"Desenvolupen un test per detectar el c\u00e0ncer de p\u00e0ncrees en minuts amb una mostra de sang"},"content":{"rendered":"<p>Un equip de l\u2019Institut de Qu\u00edmica Avan\u00e7ada de Catalunya (IQAC-CSIC), l\u2019Institut d\u2019Investigacions Biom\u00e8diques de Barcelona (IIBB-CSIC) i l\u2019Hospital del Mar Research Institute (HMRIB) ha desenvolupat un test que permet detectar el c\u00e0ncer de p\u00e0ncrees en minuts mitjan\u00e7ant l\u2019an\u00e0lisi d\u2019una mostra de sang en una tira reactiva. La prova de concepte del prototip s\u2019ha desenvolupat amb mostres de 20 pacients i 20 persones sanes a l\u2019Hospital del Mar. Es tracta del primer assaig d\u2019aquesta prova diagn\u00f2stica que identifica en el plasma sanguini una prote\u00efna (AXL) que actua com a biomarcador de l\u2019adenocarcinoma ductal pancre\u00e0tic, el tipus de c\u00e0ncer de p\u00e0ncrees m\u00e9s freq\u00fcent i letal. Els resultats revelen un m\u00e8tode senzill, port\u00e0til i econ\u00f2mic que haur\u00e0 de ser optimitzat abans de la seva aplicaci\u00f3 cl\u00ednica.<\/p>\n<p>El dispositiu desenvolupat utilitza una tecnologia similar a la dels tests r\u00e0pids, basada en tires reactives capaces d\u2019analitzar una mostra de plasma sanguini en pocs minuts. Mitjan\u00e7ant l\u2019optimitzaci\u00f3 de diferents components per millorar-ne la sensibilitat, la reproductibilitat i la claredat del senyal, el test va permetre distingir amb precisi\u00f3 entre pacients amb c\u00e0ncer de p\u00e0ncrees i persones sanes. Aquests resultats, publicats a la revista <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/42161204\/\" target=\"_blank\" rel=\"noopener\"><em>Talanta<\/em><\/a>, es van obtenir despr\u00e9s d\u2019analitzar mostres de 20 pacients i 20 participants sans a l\u2019Hospital del Mar de Barcelona.<\/p>\n<blockquote><p>\u201cEs tracta de la primera aplicaci\u00f3 d\u2019un immunoassaig de flux lateral quantitatiu \u2014una t\u00e8cnica diagn\u00f2stica que mesura la concentraci\u00f3 d\u2019una subst\u00e0ncia en una mostra l\u00edquida\u2014 per detectar sAXL en plasma\u201d, destaca <strong>Juan Pablo Salvador<\/strong>, investigador de l\u2019IQAC-CSIC i autor de l\u2019estudi.<\/p><\/blockquote>\n<p>L\u2019assaig mostra la capacitat del nou m\u00e8tode per identificar la pres\u00e8ncia a la sang de la prote\u00efna AXL, un biomarcador de l\u2019adenocarcinoma ductal pancre\u00e0tic. Aquesta prote\u00efna es troba a la superf\u00edcie de les c\u00e8l\u00b7lules i forma part del funcionament normal de l\u2019organisme, per\u00f2 s\u2019expressa en exc\u00e9s en determinats tipus de c\u00e0ncer: en el cas del p\u00e0ncrees, apareix en nivells anormalment elevats en m\u00e9s del 70 % dels tumors. \u201cFa uns anys vam demostrar que la pres\u00e8ncia d\u2019aquesta prote\u00efna soluble a la sang (sAXL) \u00e9s <a href=\"https:\/\/www.csic.es\/es\/actualidad-del-csic\/identifican-un-nuevo-biomarcador-para-el-diagnostico-precoz-del-cancer-de-pancreas\" target=\"_blank\" rel=\"noopener\">un marcador de pacients que ja han desenvolupat el tumor<\/a>\u201d, explica <strong>Pilar Navarro<\/strong>, investigadora de l\u2019IIBB-CSIC i coordinadora del Grup de Recerca en Noves Dianes Moleculars del C\u00e0ncer de l\u2019HMRIB.<\/p>\n<p>L\u2019equip investigador va validar les mesures obtingudes comparant-les amb t\u00e8cniques est\u00e0ndard com l\u2019ELISA, una modalitat diagn\u00f2stica de refer\u00e8ncia en laboratoris especialitzats i hospitals que quantifica la pres\u00e8ncia d\u2019anticossos. \u201cAquesta comparaci\u00f3 ens va permetre confirmar la rellev\u00e0ncia diagn\u00f2stica del m\u00e8tode\u201d, afegeix Navarro.<\/p>\n<p>El treball representa un aven\u00e7 prometedor per als pacients amb adenocarcinoma ductal pancre\u00e0tic, que constitueix la tercera causa de mort per c\u00e0ncer als pa\u00efsos desenvolupats. En part, aix\u00f2 es deu al fet que aquest tipus de tumor \u00e9s dif\u00edcil de detectar en les primeres etapes, de manera que m\u00e9s del 85 % dels diagn\u00f2stics s\u2019obtenen quan ja no \u00e9s operable. \u201cDisposar d\u2019eines r\u00e0pides, accessibles i m\u00ednimament invasives per millorar-ne la detecci\u00f3 preco\u00e7 representa una necessitat cl\u00ednica urgent\u201d, remarquen els investigadors.<\/p>\n<h4>Avantatges respecte d\u2019altres m\u00e8todes diagn\u00f2stics<\/h4>\n<p>La tecnologia presenta avantatges importants respecte dels m\u00e8todes diagn\u00f2stics convencionals: requereix un equipament m\u00ednim, redueix els temps d\u2019an\u00e0lisi i es podria adaptar f\u00e0cilment a entorns cl\u00ednics amb recursos limitats o a proves descentralitzades al punt d\u2019atenci\u00f3 sanit\u00e0ria (<em>point-of-care testing<\/em>), facilitant un diagn\u00f2stic m\u00e9s accessible.<\/p>\n<p>En aquest sentit, Pilar Navarro assenyala que \u201cel nostre objectiu \u00e9s desenvolupar eines diagn\u00f2stiques senzilles i accessibles que puguin apropar la detecci\u00f3 del c\u00e0ncer de p\u00e0ncrees a la pr\u00e0ctica cl\u00ednica habitual i contribuir a millorar la superviv\u00e8ncia dels pacients mitjan\u00e7ant un diagn\u00f2stic preco\u00e7\u201d. <strong>N\u00faria V\u00e1zquez-Bell\u00f3n<\/strong>, primera autora del treball, afegeix que \u201ces tracta d\u2019un primer pas prometedor, tot i que encara caldr\u00e0 optimitzar el sistema abans de la seva possible aplicaci\u00f3 cl\u00ednica\u201d.<\/p>\n<h4>Una col\u00b7laboraci\u00f3 interdisciplin\u00e0ria<\/h4>\n<p>L\u2019estudi \u00e9s fruit d\u2019una col\u00b7laboraci\u00f3 impulsada pel programa de finan\u00e7ament llavor BBQ-CSIC 2022 i, en paraules de <strong>Pablo Garc\u00eda de Frutos<\/strong>, coordinador del grup Hem\u00f2stasi i Immunitat de l\u2019IIBB: \u201cAquest treball exemplifica el valor dels ajuts llavor del CSIC per impulsar recerca interdisciplin\u00e0ria amb potencial translacional\u201d. Aix\u00ed mateix, ha comptat amb finan\u00e7ament de l\u2019Instituto de Salud Carlos III i del Ministeri de Ci\u00e8ncia, Innovaci\u00f3 i Universitats. Tamb\u00e9 ha rebut el suport de l\u2019associaci\u00f3 de pacients amb c\u00e0ncer de p\u00e0ncrees Acanpan, que ha contribu\u00eft al finan\u00e7ament del projecte i a refor\u00e7ar-ne l\u2019orientaci\u00f3 cap a les necessitats reals dels pacients.<\/p>\n<p>Els investigadors participants tamb\u00e9 estan vinculats als Centres de Recerca Biom\u00e8dica en Xarxa (CIBER) de Bioenginyeria, Biomaterials i Nanomedicina (CIBER-BBN), de Malalties Cardiovasculars (CIBER-CV) i de Malalties Hep\u00e0tiques i Digestives (CIBER-EHD), aix\u00ed com a l\u2019Institut d\u2019Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS). En aquest projecte col\u00b7laboratiu tamb\u00e9 han participat investigadors cl\u00ednics de l\u2019HMRIB especialistes en c\u00e0ncer pancre\u00e0tic i patologies digestives.<\/p>\n<p>\u201cEls futurs estudis se centraran a ampliar el nombre de pacients analitzats i a millorar encara m\u00e9s la sensibilitat del sistema per avan\u00e7ar cap a la seva possible aplicaci\u00f3 cl\u00ednica\u201d, conclouen els investigadors.<\/p>\n<p>&nbsp;<\/p>\n<p style=\"font-size: 75%;\">N\u00faria V\u00e1zquez-Bell\u00f3n, Montserrat Rodr\u00edguez-N\u00fa\u00f1ez, Neus Mart\u00ednez-Bosch, Luis E. Barranco, Laura Visa, Pablo Garc\u00eda de Frutos, M. Pilar Marco, Pilar Navarro, J. Pablo Salvador. <strong>Lateral flow immunoassay detection of soluble AXL for pancreatic ductal adenocarcinoma diagnosis<\/strong>. <em>Talanta<\/em>. DOI: <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/42161204\/\" target=\"_blank\" rel=\"noopener\">10.1016\/j.talanta.2026.129973<\/a><\/p>\n<p>&nbsp;<\/p>\n<p style=\"text-align: right;\"><strong>CSIC Comunicaci\u00f3<\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Un equip de l\u2019Institut de Qu\u00edmica Avan\u00e7ada de Catalunya (IQAC-CSIC), l\u2019Institut d\u2019Investigacions Biom\u00e8diques de Barcelona (IIBB-CSIC) i l\u2019Hospital del Mar Research Institute (HMRIB) ha desenvolupat un test que permet detectar el c\u00e0ncer de p\u00e0ncrees en minuts mitjan\u00e7ant l\u2019an\u00e0lisi d\u2019una mostra de sang en una tira reactiva. La prova de concepte del prototip s\u2019ha desenvolupat amb<a class=\"more-link\" href=\"https:\/\/www.iqac.csic.es\/ca\/desenvolupen-un-test-per-detectar-el-cancer-de-pancrees-en-minuts-amb-una-mostra-de-sang\/\">Continue reading <span class=\"screen-reader-text\">\u00abDesenvolupen un test per detectar el c\u00e0ncer de p\u00e0ncrees en minuts amb una mostra de sang\u00bb<\/span><\/a><\/p>\n","protected":false},"author":3,"featured_media":4611,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[73],"tags":[],"class_list":["post-8368","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news","entry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.7 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Desenvolupen un test per detectar el c\u00e0ncer de p\u00e0ncrees en minuts amb una mostra de sang | IQAC - Institut de Qu\u00edmica Avan\u00e7ada de Catalunya - CSIC<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.iqac.csic.es\/ca\/desenvolupen-un-test-per-detectar-el-cancer-de-pancrees-en-minuts-amb-una-mostra-de-sang\/\" \/>\n<meta property=\"og:locale\" content=\"ca_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Desenvolupen un test per detectar el c\u00e0ncer de p\u00e0ncrees en minuts amb una mostra de sang | IQAC - Institut de Qu\u00edmica Avan\u00e7ada de Catalunya - CSIC\" \/>\n<meta property=\"og:description\" content=\"Un equip de l\u2019Institut de Qu\u00edmica Avan\u00e7ada de Catalunya (IQAC-CSIC), l\u2019Institut d\u2019Investigacions Biom\u00e8diques de Barcelona (IIBB-CSIC) i l\u2019Hospital del Mar Research Institute (HMRIB) ha desenvolupat un test que permet detectar el c\u00e0ncer de p\u00e0ncrees en minuts mitjan\u00e7ant l\u2019an\u00e0lisi d\u2019una mostra de sang en una tira reactiva. 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