{"id":11086,"date":"2026-07-07T12:27:43","date_gmt":"2026-07-07T10:27:43","guid":{"rendered":"https:\/\/www.iqac.csic.es\/proyecto\/peptids-amfifilics-autoassemblats-per-a-ladministracio-ocular-de-farmacs\/"},"modified":"2026-07-07T12:27:43","modified_gmt":"2026-07-07T10:27:43","slug":"peptids-amfifilics-autoassemblats-per-a-ladministracio-ocular-de-farmacs","status":"publish","type":"proyecto","link":"https:\/\/www.iqac.csic.es\/ca\/projecte\/peptids-amfifilics-autoassemblats-per-a-ladministracio-ocular-de-farmacs\/","title":{"rendered":"P\u00e8ptids amfif\u00edlics autoassemblats per a l\u2019administraci\u00f3 ocular de f\u00e0rmacs"},"content":{"rendered":"<p>El desenvolupament de tractaments espec\u00edfics, efica\u00e7os i segurs per a pacients amb glaucoma, capa\u00e7os de disminuir la pressi\u00f3 intraocular i exercir neuroprotecci\u00f3, constitueix una necessitat m\u00e8dica no coberta i \u00e9s l\u2019objectiu principal del projecte recentment concedit, coordinat entre l\u2019IQAC-CSIC i la UB, titulat: \u00abNanopart\u00edcules lip\u00eddiques amb p\u00e8ptids autoassemblats, de nova generaci\u00f3 per a l\u2019encapsulaci\u00f3 dual de f\u00e0rmacs: un pas m\u00e9s enll\u00e0 dels sistemes d\u2019administraci\u00f3 de f\u00e0rmacs biocompatibles per a la neurodegeneraci\u00f3 glaucomatosa\u00bb. El projecte, que es dur\u00e0 a terme a l\u2019IQAC-CSIC, se centrar\u00e0 en el disseny i la s\u00edntesi d\u2019estructures autoassemblades basades en p\u00e8ptids amfif\u00edlics (PA) per a l\u2019administraci\u00f3 de f\u00e0rmacs als teixits oculars. Els PA, caracteritzats per una estructura amb components hidrof\u00edlics i hidrof\u00f2bics diferenciats, tenen la capacitat d\u2019autoassemblar-se en soluci\u00f3 aquosa per formar nanoestructures que permeten l\u2019encapsulaci\u00f3 de f\u00e0rmacs poc solubles en solucions aquoses. Els PA autoassemblats, amb capacitat de dirigir-se de manera espec\u00edfica a les c\u00e8l\u00b7lules ganglionars de la retina, milloraran la biodisponibilitat de f\u00e0rmacs poc solubles als teixits oculars.   <\/p>\n","protected":false},"excerpt":{"rendered":"<p>L\u2019objectiu d\u2019aquest projecte \u00e9s el disseny i la s\u00edntesi d\u2019estructures autoassemblades basades en p\u00e8ptids amfif\u00edlics per encapsular f\u00e0rmacs i travessar la barrera hematorretiniana amb la finalitat d\u2019actuar espec\u00edficament sobre les c\u00e8l\u00b7lules ganglionars de la retina.<\/p>\n","protected":false},"featured_media":11087,"parent":0,"template":"","meta":{"_acf_changed":false},"tags":[192,186],"enfermedad":[195],"framework":[131],"linea-de-investigacion":[184,168],"class_list":["post-11086","proyecto","type-proyecto","status-publish","has-post-thumbnail","hentry","tag-nanomedicina","tag-peptids","enfermedad-oftalmologica","framework-plan-estatal-peicti","linea-de-investigacion-comprendre","linea-de-investigacion-tractar","entry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.7 - 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