{"id":11110,"date":"2026-07-07T11:58:45","date_gmt":"2026-07-07T09:58:45","guid":{"rendered":"https:\/\/www.iqac.csic.es\/proyecto\/gel-hidrolipidic-com-a-material-de-substitucio-del-mantell-acid-en-patologies-cutanies\/"},"modified":"2026-07-07T11:58:45","modified_gmt":"2026-07-07T09:58:45","slug":"gel-hidrolipidic-com-a-material-de-substitucio-del-mantell-acid-en-patologies-cutanies","status":"publish","type":"proyecto","link":"https:\/\/www.iqac.csic.es\/ca\/projecte\/gel-hidrolipidic-com-a-material-de-substitucio-del-mantell-acid-en-patologies-cutanies\/","title":{"rendered":"Gel hidrolip\u00eddic com a material de substituci\u00f3 del mantell \u00e0cid en patologies cut\u00e0nies"},"content":{"rendered":"<p>La pell actua com a barrera protectora gr\u00e0cies, entre altres elements, al mantell \u00e0cid, una fina pel\u00b7l\u00edcula hidrolip\u00eddica situada a l&#8217;estrat corni que evita la deshidrataci\u00f3, protegeix enfront d&#8217;infeccions i mant\u00e9 l&#8217;equilibri cutani. En malalties com la dermatitis at\u00f2pica o la ictiosi, aquest mantell est\u00e0 alterat o absent, contribuint al desenvolupament i cronificaci\u00f3 de la malaltia. Actualment no existeixen materials capa\u00e7os de substituir-lo i els tractaments disponibles s\u00f3n principalment simptom\u00e0tics i poc efica\u00e7os. Aquest projecte proposa desenvolupar un material biomim\u00e8tic basat en un gel hidrolip\u00eddic nanoestructurat capa\u00e7 d&#8217;imitar el mantell \u00e0cid i restaurar la funcionalitat de la pell malalta. El projecte combinar\u00e0 estudis fisicoqu\u00edmics i biom\u00e8dics, incloent caracteritzaci\u00f3 del material, an\u00e0lisi lip\u00eddica de pell sana i malalta i avaluaci\u00f3 in vitro i in vivo de la seva efic\u00e0cia terap\u00e8utica.    <\/p>\n","protected":false},"excerpt":{"rendered":"<p>Aquest projecte desenvolupa un gel biomim\u00e8tic que imita el mantell \u00e0cid de la pell per restaurar la funci\u00f3 barrera en malalties cr\u00f2niques com la dermatitis o la ictiosi.<\/p>\n","protected":false},"featured_media":11111,"parent":0,"template":"","meta":{"_acf_changed":false},"tags":[205,169],"enfermedad":[204],"framework":[131],"linea-de-investigacion":[184,168],"class_list":["post-11110","proyecto","type-proyecto","status-publish","has-post-thumbnail","hentry","tag-lipids","tag-quimica-medica","enfermedad-dermatologica","framework-plan-estatal-peicti","linea-de-investigacion-comprendre","linea-de-investigacion-tractar","entry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.7 - 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