{"id":11116,"date":"2026-07-06T16:02:57","date_gmt":"2026-07-06T14:02:57","guid":{"rendered":"https:\/\/www.iqac.csic.es\/proyecto\/terapia-de-reemplacament-lipidic-per-a-pacients-amb-ictiosi-congenita-mitjancant-sistemes-nanoestructurats-dadministracio-topica-dacilceramides\/"},"modified":"2026-07-06T16:02:57","modified_gmt":"2026-07-06T14:02:57","slug":"terapia-de-reemplacament-lipidic-per-a-pacients-amb-ictiosi-congenita-mitjancant-sistemes-nanoestructurats-dadministracio-topica-dacilceramides","status":"publish","type":"proyecto","link":"https:\/\/www.iqac.csic.es\/ca\/projecte\/terapia-de-reemplacament-lipidic-per-a-pacients-amb-ictiosi-congenita-mitjancant-sistemes-nanoestructurats-dadministracio-topica-dacilceramides\/","title":{"rendered":"Ter\u00e0pia de reempla\u00e7ament lip\u00eddic per a pacients amb ictiosi cong\u00e8nita mitjan\u00e7ant sistemes nanoestructurats d\u2019administraci\u00f3 t\u00f2pica d\u2019acilceramides."},"content":{"rendered":"<p>Les ictiosis heredit\u00e0ries s\u00f3n malalties gen\u00e8tiques rares (13,3 casos per mili\u00f3 a Europa) que apareixen en n\u00e9ixer o a la primera inf\u00e0ncia i causen descamaci\u00f3, engruiximent cutani, sequedat, picor i dolor. Aproximadament la meitat dels pacients, especialment amb Ictiosi Cong\u00e8nita Autos\u00f2mica Recessiva (ARCI), presenten un defecte en la s\u00edntesi de CerEOS, una ceramida essencial per a la barrera epid\u00e8rmica. Els tractaments actuals s\u00f3n nom\u00e9s simptom\u00e0tics i poc efica\u00e7os. El projecte LIPARCI II desenvolupa una ter\u00e0pia de reempla\u00e7ament lip\u00eddic basada en CerEOS encapsulada en nanopart\u00edcules biomim\u00e8tiques, capaces de restaurar la barrera cut\u00e0nia en models precl\u00ednics d\u2019ARCI. A m\u00e9s, LIPARCI II inclou un assaig cl\u00ednic de fase 0 per avaluar la biodisponibilitat, avan\u00e7ar\u00e0 en la producci\u00f3 a gran escala i desenvolupar\u00e0 nous models i formulacions per ampliar el nombre de pacients beneficiaris.   <\/p>\n","protected":false},"excerpt":{"rendered":"<p>LIPARCI II desenvolupa una ter\u00e0pia basada en nanopart\u00edcules per reparar la pell amb ictiosi, una malaltia rara. El projecte inclou assaigs cl\u00ednics i noves formulacions. <\/p>\n","protected":false},"featured_media":11117,"parent":0,"template":"","meta":{"_acf_changed":false},"tags":[205,169],"enfermedad":[204,191],"framework":[128],"linea-de-investigacion":[184,168],"class_list":["post-11116","proyecto","type-proyecto","status-publish","has-post-thumbnail","hentry","tag-lipids","tag-quimica-medica","enfermedad-dermatologica","enfermedad-malalties-rares","framework-horizon-europe","linea-de-investigacion-comprendre","linea-de-investigacion-tractar","entry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.7 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Ter\u00e0pia de reempla\u00e7ament lip\u00eddic per a pacients amb ictiosi cong\u00e8nita mitjan\u00e7ant sistemes nanoestructurats d\u2019administraci\u00f3 t\u00f2pica d\u2019acilceramides. | IQAC - Institut de Qu\u00edmica Avan\u00e7ada de Catalunya - CSIC<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.iqac.csic.es\/proyecto\/terapia-de-reemplazo-lipidico-para-pacientes-con-ictiosis-congenita-mediante-sistemas-nanoestructurados-de-administracion-topica-de-acilceramidas\/\" \/>\n<meta property=\"og:locale\" content=\"ca_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Ter\u00e0pia de reempla\u00e7ament lip\u00eddic per a pacients amb ictiosi cong\u00e8nita mitjan\u00e7ant sistemes nanoestructurats d\u2019administraci\u00f3 t\u00f2pica d\u2019acilceramides. | IQAC - Institut de Qu\u00edmica Avan\u00e7ada de Catalunya - CSIC\" \/>\n<meta property=\"og:description\" content=\"LIPARCI II desenvolupa una ter\u00e0pia basada en nanopart\u00edcules per reparar la pell amb ictiosi, una malaltia rara. 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