{"id":11118,"date":"2026-07-06T16:36:05","date_gmt":"2026-07-06T14:36:05","guid":{"rendered":"https:\/\/www.iqac.csic.es\/proyecto\/eines-de-biologia-quimica-per-a-la-sintesi-i-lestudi-de-proteines-modificades-posttraduccionalment-amb-lipids\/"},"modified":"2026-07-06T16:36:05","modified_gmt":"2026-07-06T14:36:05","slug":"eines-de-biologia-quimica-per-a-la-sintesi-i-lestudi-de-proteines-modificades-posttraduccionalment-amb-lipids","status":"publish","type":"proyecto","link":"https:\/\/www.iqac.csic.es\/ca\/projecte\/eines-de-biologia-quimica-per-a-la-sintesi-i-lestudi-de-proteines-modificades-posttraduccionalment-amb-lipids\/","title":{"rendered":"Eines de biologia qu\u00edmica per a la s\u00edntesi i l&#8217;estudi de prote\u00efnes modificades posttraduccionalment amb l\u00edpids"},"content":{"rendered":"<p>La uni\u00f3 de l\u00edpids \u00e9s un mecanisme potent per modular el comportament de les prote\u00efnes i regular processos de senyalitzaci\u00f3 i relacionats amb la malaltia, encara que les conseq\u00fc\u00e8ncies moleculars de moltes modificacions lip\u00eddiques continuen sent poc compreses. Aquest projecte se centrar\u00e0 en el desenvolupament d&#8217;eines qu\u00edmiques i biol\u00f2giques per a l&#8217;estudi de prote\u00efnes modificades amb l\u00edpids, amb un \u00e8mfasi especial en prote\u00efnes Hedgehog, unides a colesterol en l&#8217;extrem C-terminal i prote\u00efnes S-acilades, en les quals \u00e0cids grassos s&#8217;uneixen de forma reversible a residus de ciste\u00efna. Per assolir aquests objectius, desenvoluparem nous m\u00e8todes de s\u00edntesi de prote\u00efnes i ligaci\u00f3 pept\u00eddica, i combinarem el disseny de sondes amb an\u00e0lisis basades en espectrometria de masses per estudiar prote\u00efnes lipidades i els enzims implicats en el seu metabolisme, incloses prote\u00efnes associades a malalties neurodegeneratives pedi\u00e0triques rares.  <\/p>\n","protected":false},"excerpt":{"rendered":"<p>La uni\u00f3 de l\u00edpids modula la localitzaci\u00f3, les interaccions i la funci\u00f3 de les prote\u00efnes, i la seva desregulaci\u00f3 s&#8217;associa amb m\u00faltiples malalties. Aquest projecte desenvolupar\u00e0 eines qu\u00edmiques i biol\u00f2giques per sintetitzar i estudiar prote\u00efnes modificades amb l\u00edpids, amb una atenci\u00f3 especial a la colesterilaci\u00f3 de Hedgehog, la S-acilaci\u00f3 de prote\u00efnes, aix\u00ed com als enzims implicats en el seu metabolisme. <\/p>\n","protected":false},"featured_media":11119,"parent":0,"template":"","meta":{"_acf_changed":false},"tags":[205,207],"enfermedad":[],"framework":[131],"linea-de-investigacion":[184],"class_list":["post-11118","proyecto","type-proyecto","status-publish","has-post-thumbnail","hentry","tag-lipids","tag-proteines","framework-plan-estatal-peicti","linea-de-investigacion-comprendre","entry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.7 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Eines de biologia qu\u00edmica per a la s\u00edntesi i l&#039;estudi de prote\u00efnes modificades posttraduccionalment amb l\u00edpids | IQAC - Institut de Qu\u00edmica Avan\u00e7ada de Catalunya - CSIC<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.iqac.csic.es\/proyecto\/herramientas-de-biologia-quimica-para-la-sintesis-y-el-estudio-de-proteinas-modificadas-postraduccionalmente-con-lipidos\/\" \/>\n<meta property=\"og:locale\" content=\"ca_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Eines de biologia qu\u00edmica per a la s\u00edntesi i l&#039;estudi de prote\u00efnes modificades posttraduccionalment amb l\u00edpids | IQAC - Institut de Qu\u00edmica Avan\u00e7ada de Catalunya - CSIC\" \/>\n<meta property=\"og:description\" content=\"La uni\u00f3 de l\u00edpids modula la localitzaci\u00f3, les interaccions i la funci\u00f3 de les prote\u00efnes, i la seva desregulaci\u00f3 s&#039;associa amb m\u00faltiples malalties. 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