{"id":11152,"date":"2026-07-06T14:22:09","date_gmt":"2026-07-06T12:22:09","guid":{"rendered":"https:\/\/www.iqac.csic.es\/proyecto\/inhibidors-dautofagia-fotoactivables-per-eliminar-cellules-mare-tumorals-amb-alta-precisio\/"},"modified":"2026-07-06T14:22:09","modified_gmt":"2026-07-06T12:22:09","slug":"inhibidors-dautofagia-fotoactivables-per-eliminar-cellules-mare-tumorals-amb-alta-precisio","status":"publish","type":"proyecto","link":"https:\/\/www.iqac.csic.es\/ca\/projecte\/inhibidors-dautofagia-fotoactivables-per-eliminar-cellules-mare-tumorals-amb-alta-precisio\/","title":{"rendered":"Inhibidors d\u2019autof\u00e0gia fotoactivables per eliminar c\u00e8l\u00b7lules mare tumorals amb alta precisi\u00f3"},"content":{"rendered":"<p>Les c\u00e8l\u00b7lules mare canceroses (CSC) solen ser responsables de les recaigudes, i un dels seus mecanismes de superviv\u00e8ncia \u00e9s l\u2019autof\u00e0gia. Tanmateix, malgrat el potencial dels inhibidors de l\u2019autof\u00e0gia per eliminar les CSC, els efectes sobre les c\u00e8l\u00b7lules sanes en dificulten l\u2019avan\u00e7 cl\u00ednic. <\/p>\n<p>La fotofarmacologia busca controlar l\u2019activitat de mol\u00e8cules bioactives amb llum externa, localitzant l\u2019activitat del f\u00e0rmac en l\u2019espai i el temps. Creiem que les mol\u00e8cules fotosensibles dirigides a les CSC podrien eliminar-les efica\u00e7ment sense causar efectes secundaris, augmentant l\u2019efic\u00e0cia i la seguretat dels f\u00e0rmacs anti-CSC. <\/p>\n<p>En aquest projecte, finan\u00e7at per l\u2019Associaci\u00f3 Espanyola Contra el C\u00e0ncer (AECC) dins d\u2019<em>Idees Llavor<\/em>, estem (1) establint la primera prova de concepte in vivo sobre l\u2019\u00fas d\u2019inhibidors irreversibles de l\u2019autof\u00e0gia activables per llum, i (2) desenvolupant els primers inhibidors d\u2019ULK1 que bloquegen l\u2019autof\u00e0gia nom\u00e9s sota il\u00b7luminaci\u00f3 de manera reversible.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Estem desenvolupant inhibidors de l\u2019autof\u00e0gia que s\u2019activen mitjan\u00e7ant llum externa per eliminar selectivament c\u00e8l\u00b7lules mare canceroses. Seguim dos enfocaments basats en photoswitches i photocages. <\/p>\n","protected":false},"featured_media":11153,"parent":0,"template":"","meta":{"_acf_changed":false},"tags":[170,169],"enfermedad":[167],"framework":[132],"linea-de-investigacion":[184,168],"class_list":["post-11152","proyecto","type-proyecto","status-publish","has-post-thumbnail","hentry","tag-descobriment-de-farmacs","tag-quimica-medica","enfermedad-cancer","framework-fundacion-aecc","linea-de-investigacion-comprendre","linea-de-investigacion-tractar","entry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.7 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Inhibidors d\u2019autof\u00e0gia fotoactivables per eliminar c\u00e8l\u00b7lules mare tumorals amb alta precisi\u00f3 | IQAC - Institut de Qu\u00edmica Avan\u00e7ada de Catalunya - CSIC<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.iqac.csic.es\/proyecto\/inhibidores-de-autofagia-foto-activables-para-eliminar-celulas-madre-tumorales-con-alta-precision\/\" \/>\n<meta property=\"og:locale\" content=\"ca_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Inhibidors d\u2019autof\u00e0gia fotoactivables per eliminar c\u00e8l\u00b7lules mare tumorals amb alta precisi\u00f3 | IQAC - Institut de Qu\u00edmica Avan\u00e7ada de Catalunya - CSIC\" \/>\n<meta property=\"og:description\" content=\"Estem desenvolupant inhibidors de l\u2019autof\u00e0gia que s\u2019activen mitjan\u00e7ant llum externa per eliminar selectivament c\u00e8l\u00b7lules mare canceroses. 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