{"id":11167,"date":"2026-07-06T14:11:19","date_gmt":"2026-07-06T12:11:19","guid":{"rendered":"https:\/\/www.iqac.csic.es\/proyecto\/aproximacions-de-biologia-quimica-per-a-la-sintesi-i-lestudi-de-proteines-modificades-amb-lipids\/"},"modified":"2026-07-06T14:11:19","modified_gmt":"2026-07-06T12:11:19","slug":"aproximacions-de-biologia-quimica-per-a-la-sintesi-i-lestudi-de-proteines-modificades-amb-lipids","status":"publish","type":"proyecto","link":"https:\/\/www.iqac.csic.es\/ca\/projecte\/aproximacions-de-biologia-quimica-per-a-la-sintesi-i-lestudi-de-proteines-modificades-amb-lipids\/","title":{"rendered":"Aproximacions de biologia qu\u00edmica per a la s\u00edntesi i l&#8217;estudi de prote\u00efnes modificades amb l\u00edpids"},"content":{"rendered":"<p>Els l\u00edpids s\u00f3n components cel\u00b7lulars essencials implicats en l&#8217;emmagatzematge d&#8217;energia, l&#8217;organitzaci\u00f3 de membranes, la senyalitzaci\u00f3 cel\u00b7lular i la regulaci\u00f3 de la funci\u00f3 proteica. Les prote\u00efnes poden modificar-se postraduccionalment mitjan\u00e7ant la uni\u00f3 covalent de l\u00edpids, que els confereixen car\u00e0cter hidrof\u00f2bic, afavoreixen l&#8217;associaci\u00f3 a membranes i poden modular interaccions prote\u00efna-prote\u00efna. <\/p>\n<p>Les lipidacions m\u00e9s comunes inclouen la S-prenilaci\u00f3 de ciste\u00efnes, la miristo\u00eflaci\u00f3 de glicines, la S-acilaci\u00f3 i la incorporaci\u00f3 d&#8217;unitats de GPI. Altres modificacions rellevants s\u00f3n la colesterilaci\u00f3 de prote\u00efnes Hedgehog i la conjugaci\u00f3 de fosfatidiletanolamina a GABARAP i LC3. <\/p>\n<p>Aquest projecte estudiar\u00e0 les prote\u00efnes lipidades mitjan\u00e7ant la identificaci\u00f3 i quantificaci\u00f3 dels l\u00edpids units a elles i el desenvolupament de m\u00e8todes de s\u00edntesi qu\u00edmica o semis\u00edntesi, amb l&#8217;objectiu de comprendre millor la seva funci\u00f3.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Les prote\u00efnes es modifiquen mitjan\u00e7ant la uni\u00f3 covalent d&#8217;una \u00e0mplia varietat de l\u00edpids, i aquestes modificacions regulen la seva localitzaci\u00f3, les seves interaccions i la seva funci\u00f3. Aquest projecte t\u00e9 com a objectiu identificar i quantificar els l\u00edpids units a prote\u00efnes i generar prote\u00efnes modificades, obtingudes mitjan\u00e7ant m\u00e8todes de s\u00edntesi qu\u00edmica o semis\u00edntesi. <\/p>\n","protected":false},"featured_media":11169,"parent":0,"template":"","meta":{"_acf_changed":false},"tags":[207,169,217],"enfermedad":[],"framework":[131],"linea-de-investigacion":[184,168],"class_list":["post-11167","proyecto","type-proyecto","status-publish","has-post-thumbnail","hentry","tag-proteines","tag-quimica-medica","tag-sintesi-organica","framework-plan-estatal-peicti","linea-de-investigacion-comprendre","linea-de-investigacion-tractar","entry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.7 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Aproximacions de biologia qu\u00edmica per a la s\u00edntesi i l&#039;estudi de prote\u00efnes modificades amb l\u00edpids | IQAC - Institut de Qu\u00edmica Avan\u00e7ada de Catalunya - CSIC<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.iqac.csic.es\/proyecto\/aproximaciones-de-biologia-quimica-para-la-sintesis-y-el-estudio-de-proteinas-modificadas-con-lipidos\/\" \/>\n<meta property=\"og:locale\" content=\"ca_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Aproximacions de biologia qu\u00edmica per a la s\u00edntesi i l&#039;estudi de prote\u00efnes modificades amb l\u00edpids | IQAC - Institut de Qu\u00edmica Avan\u00e7ada de Catalunya - CSIC\" \/>\n<meta property=\"og:description\" content=\"Les prote\u00efnes es modifiquen mitjan\u00e7ant la uni\u00f3 covalent d&#039;una \u00e0mplia varietat de l\u00edpids, i aquestes modificacions regulen la seva localitzaci\u00f3, les seves interaccions i la seva funci\u00f3. 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