{"id":11188,"date":"2026-07-06T15:46:18","date_gmt":"2026-07-06T13:46:18","guid":{"rendered":"https:\/\/www.iqac.csic.es\/proyecto\/vesicules-extracellulars-hibrides-per-al-tractament-avancat-de-malalties-de-diposit-lisosomal\/"},"modified":"2026-07-06T15:46:18","modified_gmt":"2026-07-06T13:46:18","slug":"vesicules-extracellulars-hibrides-per-al-tractament-avancat-de-malalties-de-diposit-lisosomal","status":"publish","type":"proyecto","link":"https:\/\/www.iqac.csic.es\/ca\/projecte\/vesicules-extracellulars-hibrides-per-al-tractament-avancat-de-malalties-de-diposit-lisosomal\/","title":{"rendered":"Ves\u00edcules extracel\u00b7lulars h\u00edbrides per al tractament avan\u00e7at de malalties de dip\u00f2sit lisosomal"},"content":{"rendered":"<p>HEAL pret\u00e9n transformar el tractament dels trastorns de dip\u00f2sit lisosomal, amb focus en la malaltia de Fabry, mitjan\u00e7ant nanopart\u00edcules de tercera generaci\u00f3 que combinen ves\u00edcules extracel\u00b7lulars i liposomes (ELs) per lliurar enzims altament actius a \u00f2rgans diana. El projecte integra intel\u00b7lig\u00e8ncia artificial per optimitzar el disseny, la direccionalitzaci\u00f3 i una fabricaci\u00f3 escalable, i avalua la seva efic\u00e0cia en models precl\u00ednics avan\u00e7ats que reprodueixen millor la malaltia humana. L&#8217;objectiu \u00e9s millorar l&#8217;estabilitat, la biodistribuci\u00f3 i el possible acc\u00e9s al cervell, superant les limitacions de l&#8217;ERT convencional.  <\/p>\n","protected":false},"excerpt":{"rendered":"<p>HEAL desenvolupa nanopart\u00edcules h\u00edbrides de ves\u00edcules extracel\u00b7lulars i liposomes per portar enzims terap\u00e8utics als \u00f2rgans afectats per la malaltia de Fabry. Amb l&#8217;ajuda de la IA i models avan\u00e7ats, busca superar les limitacions de la ter\u00e0pia de reempla\u00e7ament enzim\u00e0tic actual. <\/p>\n","protected":false},"featured_media":11190,"parent":0,"template":"","meta":{"_acf_changed":false},"tags":[179,169],"enfermedad":[191],"framework":[131],"linea-de-investigacion":[184,168],"class_list":["post-11188","proyecto","type-proyecto","status-publish","has-post-thumbnail","hentry","tag-nanobiotecnologia","tag-quimica-medica","enfermedad-malalties-rares","framework-plan-estatal-peicti","linea-de-investigacion-comprendre","linea-de-investigacion-tractar","entry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.7 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Ves\u00edcules extracel\u00b7lulars h\u00edbrides per al tractament avan\u00e7at de malalties de dip\u00f2sit lisosomal | IQAC - Institut de Qu\u00edmica Avan\u00e7ada de Catalunya - CSIC<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.iqac.csic.es\/proyecto\/vesiculas-extracelulares-hibridas-para-tratamiento-avanzado-de-enfermedades-de-deposito-lisosomal\/\" \/>\n<meta property=\"og:locale\" content=\"ca_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Ves\u00edcules extracel\u00b7lulars h\u00edbrides per al tractament avan\u00e7at de malalties de dip\u00f2sit lisosomal | IQAC - Institut de Qu\u00edmica Avan\u00e7ada de Catalunya - CSIC\" \/>\n<meta property=\"og:description\" content=\"HEAL desenvolupa nanopart\u00edcules h\u00edbrides de ves\u00edcules extracel\u00b7lulars i liposomes per portar enzims terap\u00e8utics als \u00f2rgans afectats per la malaltia de Fabry. Amb l&#039;ajuda de la IA i models avan\u00e7ats, busca superar les limitacions de la ter\u00e0pia de reempla\u00e7ament enzim\u00e0tic actual.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.iqac.csic.es\/proyecto\/vesiculas-extracelulares-hibridas-para-tratamiento-avanzado-de-enfermedades-de-deposito-lisosomal\/\" \/>\n<meta property=\"og:site_name\" content=\"IQAC - Institut de Qu\u00edmica Avan\u00e7ada de Catalunya - CSIC\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/iqac.csic.es\/\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.iqac.csic.es\/wp-content\/uploads\/2026\/07\/heal-1.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"2000\" \/>\n\t<meta property=\"og:image:height\" content=\"1125\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:site\" content=\"@IQAC_CSIC\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.iqac.csic.es\\\/proyecto\\\/vesiculas-extracelulares-hibridas-para-tratamiento-avanzado-de-enfermedades-de-deposito-lisosomal\\\/\",\"url\":\"https:\\\/\\\/www.iqac.csic.es\\\/proyecto\\\/vesiculas-extracelulares-hibridas-para-tratamiento-avanzado-de-enfermedades-de-deposito-lisosomal\\\/\",\"name\":\"Ves\u00edcules extracel\u00b7lulars h\u00edbrides per al tractament avan\u00e7at de malalties de dip\u00f2sit lisosomal | IQAC - Institut de Qu\u00edmica Avan\u00e7ada de Catalunya - CSIC\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.iqac.csic.es\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/www.iqac.csic.es\\\/proyecto\\\/vesiculas-extracelulares-hibridas-para-tratamiento-avanzado-de-enfermedades-de-deposito-lisosomal\\\/#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/www.iqac.csic.es\\\/proyecto\\\/vesiculas-extracelulares-hibridas-para-tratamiento-avanzado-de-enfermedades-de-deposito-lisosomal\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/www.iqac.csic.es\\\/wp-content\\\/uploads\\\/2026\\\/07\\\/heal-1.jpg\",\"datePublished\":\"2026-07-06T13:46:18+00:00\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/www.iqac.csic.es\\\/proyecto\\\/vesiculas-extracelulares-hibridas-para-tratamiento-avanzado-de-enfermedades-de-deposito-lisosomal\\\/#breadcrumb\"},\"inLanguage\":\"ca\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/www.iqac.csic.es\\\/proyecto\\\/vesiculas-extracelulares-hibridas-para-tratamiento-avanzado-de-enfermedades-de-deposito-lisosomal\\\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"ca\",\"@id\":\"https:\\\/\\\/www.iqac.csic.es\\\/proyecto\\\/vesiculas-extracelulares-hibridas-para-tratamiento-avanzado-de-enfermedades-de-deposito-lisosomal\\\/#primaryimage\",\"url\":\"https:\\\/\\\/www.iqac.csic.es\\\/wp-content\\\/uploads\\\/2026\\\/07\\\/heal-1.jpg\",\"contentUrl\":\"https:\\\/\\\/www.iqac.csic.es\\\/wp-content\\\/uploads\\\/2026\\\/07\\\/heal-1.jpg\",\"width\":2000,\"height\":1125,\"caption\":\"Representaci\u00f3n de una ves\u00edcula extracelular h\u00edbrida para el tratamiento avanzado de enfermedades de dep\u00f3sito lisosomal.\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/www.iqac.csic.es\\\/proyecto\\\/vesiculas-extracelulares-hibridas-para-tratamiento-avanzado-de-enfermedades-de-deposito-lisosomal\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Portada\",\"item\":\"https:\\\/\\\/www.iqac.csic.es\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Ves\u00edcules extracel\u00b7lulars h\u00edbrides per al tractament avan\u00e7at de malalties de dip\u00f2sit lisosomal\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/www.iqac.csic.es\\\/#website\",\"url\":\"https:\\\/\\\/www.iqac.csic.es\\\/\",\"name\":\"IQAC - Institut de Qu\u00edmica Avan\u00e7ada de Catalunya - CSIC\",\"description\":\"Chemistry for a better life\",\"publisher\":{\"@id\":\"https:\\\/\\\/www.iqac.csic.es\\\/#organization\"},\"alternateName\":\"IQAC - Institut de Qu\u00edmica Avan\u00e7ada de Catalunya - CSIC\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/www.iqac.csic.es\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"ca\"},{\"@type\":\"Organization\",\"@id\":\"https:\\\/\\\/www.iqac.csic.es\\\/#organization\",\"name\":\"IQAC - Institut de Qu\u00edmica Avan\u00e7ada de Catalunya - CSIC\",\"alternateName\":\"IQAC - Institut de Qu\u00edmica Avan\u00e7ada de Catalunya - CSIC\",\"url\":\"https:\\\/\\\/www.iqac.csic.es\\\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"ca\",\"@id\":\"https:\\\/\\\/www.iqac.csic.es\\\/#\\\/schema\\\/logo\\\/image\\\/\",\"url\":\"https:\\\/\\\/www.iqac.csic.es\\\/wp-content\\\/uploads\\\/2025\\\/11\\\/cropped-favicon-1.png\",\"contentUrl\":\"https:\\\/\\\/www.iqac.csic.es\\\/wp-content\\\/uploads\\\/2025\\\/11\\\/cropped-favicon-1.png\",\"width\":512,\"height\":512,\"caption\":\"IQAC - Institut de Qu\u00edmica Avan\u00e7ada de Catalunya - CSIC\"},\"image\":{\"@id\":\"https:\\\/\\\/www.iqac.csic.es\\\/#\\\/schema\\\/logo\\\/image\\\/\"},\"sameAs\":[\"https:\\\/\\\/www.facebook.com\\\/iqac.csic.es\\\/\",\"https:\\\/\\\/x.com\\\/IQAC_CSIC\",\"https:\\\/\\\/www.instagram.com\\\/iqac_csic\",\"https:\\\/\\\/www.youtube.com\\\/channel\\\/UC1JXTOe3-s8UnYu_A6-SI3A\",\"https:\\\/\\\/www.linkedin.com\\\/company\\\/iqac-csic\\\/\"]}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Ves\u00edcules extracel\u00b7lulars h\u00edbrides per al tractament avan\u00e7at de malalties de dip\u00f2sit lisosomal | IQAC - Institut de Qu\u00edmica Avan\u00e7ada de Catalunya - CSIC","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.iqac.csic.es\/proyecto\/vesiculas-extracelulares-hibridas-para-tratamiento-avanzado-de-enfermedades-de-deposito-lisosomal\/","og_locale":"ca_ES","og_type":"article","og_title":"Ves\u00edcules extracel\u00b7lulars h\u00edbrides per al tractament avan\u00e7at de malalties de dip\u00f2sit lisosomal | IQAC - Institut de Qu\u00edmica Avan\u00e7ada de Catalunya - CSIC","og_description":"HEAL desenvolupa nanopart\u00edcules h\u00edbrides de ves\u00edcules extracel\u00b7lulars i liposomes per portar enzims terap\u00e8utics als \u00f2rgans afectats per la malaltia de Fabry. Amb l'ajuda de la IA i models avan\u00e7ats, busca superar les limitacions de la ter\u00e0pia de reempla\u00e7ament enzim\u00e0tic actual.","og_url":"https:\/\/www.iqac.csic.es\/proyecto\/vesiculas-extracelulares-hibridas-para-tratamiento-avanzado-de-enfermedades-de-deposito-lisosomal\/","og_site_name":"IQAC - Institut de Qu\u00edmica Avan\u00e7ada de Catalunya - CSIC","article_publisher":"https:\/\/www.facebook.com\/iqac.csic.es\/","og_image":[{"width":2000,"height":1125,"url":"https:\/\/www.iqac.csic.es\/wp-content\/uploads\/2026\/07\/heal-1.jpg","type":"image\/jpeg"}],"twitter_card":"summary_large_image","twitter_site":"@IQAC_CSIC","schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/www.iqac.csic.es\/proyecto\/vesiculas-extracelulares-hibridas-para-tratamiento-avanzado-de-enfermedades-de-deposito-lisosomal\/","url":"https:\/\/www.iqac.csic.es\/proyecto\/vesiculas-extracelulares-hibridas-para-tratamiento-avanzado-de-enfermedades-de-deposito-lisosomal\/","name":"Ves\u00edcules extracel\u00b7lulars h\u00edbrides per al tractament avan\u00e7at de malalties de dip\u00f2sit lisosomal | IQAC - Institut de Qu\u00edmica Avan\u00e7ada de Catalunya - CSIC","isPartOf":{"@id":"https:\/\/www.iqac.csic.es\/#website"},"primaryImageOfPage":{"@id":"https:\/\/www.iqac.csic.es\/proyecto\/vesiculas-extracelulares-hibridas-para-tratamiento-avanzado-de-enfermedades-de-deposito-lisosomal\/#primaryimage"},"image":{"@id":"https:\/\/www.iqac.csic.es\/proyecto\/vesiculas-extracelulares-hibridas-para-tratamiento-avanzado-de-enfermedades-de-deposito-lisosomal\/#primaryimage"},"thumbnailUrl":"https:\/\/www.iqac.csic.es\/wp-content\/uploads\/2026\/07\/heal-1.jpg","datePublished":"2026-07-06T13:46:18+00:00","breadcrumb":{"@id":"https:\/\/www.iqac.csic.es\/proyecto\/vesiculas-extracelulares-hibridas-para-tratamiento-avanzado-de-enfermedades-de-deposito-lisosomal\/#breadcrumb"},"inLanguage":"ca","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.iqac.csic.es\/proyecto\/vesiculas-extracelulares-hibridas-para-tratamiento-avanzado-de-enfermedades-de-deposito-lisosomal\/"]}]},{"@type":"ImageObject","inLanguage":"ca","@id":"https:\/\/www.iqac.csic.es\/proyecto\/vesiculas-extracelulares-hibridas-para-tratamiento-avanzado-de-enfermedades-de-deposito-lisosomal\/#primaryimage","url":"https:\/\/www.iqac.csic.es\/wp-content\/uploads\/2026\/07\/heal-1.jpg","contentUrl":"https:\/\/www.iqac.csic.es\/wp-content\/uploads\/2026\/07\/heal-1.jpg","width":2000,"height":1125,"caption":"Representaci\u00f3n de una ves\u00edcula extracelular h\u00edbrida para el tratamiento avanzado de enfermedades de dep\u00f3sito lisosomal."},{"@type":"BreadcrumbList","@id":"https:\/\/www.iqac.csic.es\/proyecto\/vesiculas-extracelulares-hibridas-para-tratamiento-avanzado-de-enfermedades-de-deposito-lisosomal\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Portada","item":"https:\/\/www.iqac.csic.es\/"},{"@type":"ListItem","position":2,"name":"Ves\u00edcules extracel\u00b7lulars h\u00edbrides per al tractament avan\u00e7at de malalties de dip\u00f2sit lisosomal"}]},{"@type":"WebSite","@id":"https:\/\/www.iqac.csic.es\/#website","url":"https:\/\/www.iqac.csic.es\/","name":"IQAC - Institut de Qu\u00edmica Avan\u00e7ada de Catalunya - CSIC","description":"Chemistry for a better life","publisher":{"@id":"https:\/\/www.iqac.csic.es\/#organization"},"alternateName":"IQAC - Institut de Qu\u00edmica Avan\u00e7ada de Catalunya - CSIC","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.iqac.csic.es\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"ca"},{"@type":"Organization","@id":"https:\/\/www.iqac.csic.es\/#organization","name":"IQAC - Institut de Qu\u00edmica Avan\u00e7ada de Catalunya - CSIC","alternateName":"IQAC - Institut de Qu\u00edmica Avan\u00e7ada de Catalunya - CSIC","url":"https:\/\/www.iqac.csic.es\/","logo":{"@type":"ImageObject","inLanguage":"ca","@id":"https:\/\/www.iqac.csic.es\/#\/schema\/logo\/image\/","url":"https:\/\/www.iqac.csic.es\/wp-content\/uploads\/2025\/11\/cropped-favicon-1.png","contentUrl":"https:\/\/www.iqac.csic.es\/wp-content\/uploads\/2025\/11\/cropped-favicon-1.png","width":512,"height":512,"caption":"IQAC - Institut de Qu\u00edmica Avan\u00e7ada de Catalunya - CSIC"},"image":{"@id":"https:\/\/www.iqac.csic.es\/#\/schema\/logo\/image\/"},"sameAs":["https:\/\/www.facebook.com\/iqac.csic.es\/","https:\/\/x.com\/IQAC_CSIC","https:\/\/www.instagram.com\/iqac_csic","https:\/\/www.youtube.com\/channel\/UC1JXTOe3-s8UnYu_A6-SI3A","https:\/\/www.linkedin.com\/company\/iqac-csic\/"]}]}},"_links":{"self":[{"href":"https:\/\/www.iqac.csic.es\/ca\/wp-json\/wp\/v2\/proyecto\/11188","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.iqac.csic.es\/ca\/wp-json\/wp\/v2\/proyecto"}],"about":[{"href":"https:\/\/www.iqac.csic.es\/ca\/wp-json\/wp\/v2\/types\/proyecto"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.iqac.csic.es\/ca\/wp-json\/wp\/v2\/media\/11190"}],"wp:attachment":[{"href":"https:\/\/www.iqac.csic.es\/ca\/wp-json\/wp\/v2\/media?parent=11188"}],"wp:term":[{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.iqac.csic.es\/ca\/wp-json\/wp\/v2\/tags?post=11188"},{"taxonomy":"enfermedad","embeddable":true,"href":"https:\/\/www.iqac.csic.es\/ca\/wp-json\/wp\/v2\/enfermedad?post=11188"},{"taxonomy":"framework","embeddable":true,"href":"https:\/\/www.iqac.csic.es\/ca\/wp-json\/wp\/v2\/framework?post=11188"},{"taxonomy":"linea-de-investigacion","embeddable":true,"href":"https:\/\/www.iqac.csic.es\/ca\/wp-json\/wp\/v2\/linea-de-investigacion?post=11188"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}