{"id":12289,"date":"2026-03-26T09:26:38","date_gmt":"2026-03-26T08:26:38","guid":{"rendered":"https:\/\/www.iqac.csic.es\/events\/phd-thesis-defence-by-arnau-dominguez-zoroa\/"},"modified":"2026-03-26T09:26:38","modified_gmt":"2026-03-26T08:26:38","slug":"phd-thesis-defence-by-arnau-dominguez-zoroa","status":"publish","type":"events","link":"https:\/\/www.iqac.csic.es\/en\/events\/phd-thesis-defence-by-arnau-dominguez-zoroa\/","title":{"rendered":"PhD Thesis Defence by Arnau Dom\u00ednguez Zoroa"},"content":{"rendered":"<p>The predoctoral researcher <strong>Arnau Dom\u00ednguez Zoroa<\/strong>, from the <a href=\"https:\/\/www.iqac.csic.es\/research\/departments\/surfactants-and-nanobiotechnology\/nucleic-acids-chemistry\/\" target=\"_blank\" rel=\"noopener\">Nucleic Acids Chemistry<\/a> group, will defend his thesis on <strong>16th April <\/strong>at <strong>15:30h<\/strong> in Aula Enric Casassas (Faculty of Chemistry, University of Barcelona)<\/p>\n<p>Title: <strong><span class=\"a_GcMg font-feature-liga-off font-feature-clig-off font-feature-calt-off text-decoration-none text-strikethrough-none\">Design and Preparation of Triplex Forming Oligonucleotides for the Detection of SARS-CoV-2 Virus<\/span><\/strong><\/p>\n<p>Directors: Anna Avi\u00f1\u00f3 and Ramon Eritja<\/p>\n<p>Thesis committee: Anna Pasternak, Juan Carlos Morales and Montserrat Terrazas<\/p>\n<p><strong>Abstract:<br \/>\n<\/strong>The COVID-19 pandemic, caused by the SARS-CoV-2 virus, has marked a turning point in modern society, highlighting the urgent need for rapid and sensitive detection systems that can be used by the general population without prior training. In this context, the present doctoral thesis describes the development of DNA probes for the detection of SARS-CoV-2 based on hairpin-type oligonucleotides capable of forming triplex structures, with the aim of overcoming some of the limitations associated with conventional techniques.<br \/>\nThrough a double-hybridization strategy involving two distinct oligonucleotides\u2014a capture probe and a reporter probe\u2014the system enables the detection of only a few femtomoles of viral messenger RNA in less than 30 minutes. Building on the group\u2019s previous expertise in the study of hairpin oligonucleotides and triple-helix structures, this thesis establishes a set of methodologies for investigating the parallel and antiparallel triplexes formed by these capture probes using a range of biophysical techniques.<br \/>\nThe results obtained allowed the identification of key structural features and modification patterns required for these hairpins to achieve optimal performance in biosensing platforms, thereby improving detection limits and establishing a framework for the design and optimization of similar systems targeting other pathogens.<\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Title: Design and Preparation of Triplex Forming Oligonucleotides for the Detection of SARS-CoV-2 Virus<\/p>\n","protected":false},"author":3,"featured_media":12290,"parent":0,"template":"","meta":{"_acf_changed":false},"tipo-de-evento":[344],"class_list":["post-12289","events","type-events","status-publish","has-post-thumbnail","hentry","tipo-de-evento-phd-thesis-presentation","entry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.7 - 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