{"id":7723,"date":"2020-11-30T10:29:09","date_gmt":"2020-11-30T09:29:09","guid":{"rendered":"https:\/\/www.iqac.csic.es\/phd-thesis-defence-by-maria-ricart\/"},"modified":"2026-06-16T11:11:08","modified_gmt":"2026-06-16T09:11:08","slug":"phd-thesis-defence-by-maria-ricart","status":"publish","type":"post","link":"https:\/\/www.iqac.csic.es\/en\/phd-thesis-defence-by-maria-ricart\/","title":{"rendered":"PhD thesis defence by Maria Ricart"},"content":{"rendered":"<p>The Predoctoral Researcher <strong>Maria Ricart\u00a0<\/strong>from\u00a0<a href=\"https:\/\/www.iqac.csic.es\/mcs\/\" target=\"_blank\" rel=\"noopener noreferrer\"><strong>Medicinal Chemistry &amp; Synthesis\u00a0<\/strong><strong>(MCS) group<\/strong><\/a> is defending her thesis next\u00a0 <strong>4th December 2020\u00a0<\/strong>at\u00a0<strong>10:00h.<\/strong><\/p>\n<p><strong>Title:\u00a0<\/strong><\/p>\n<p><strong>Innovative tool to decipher the mode of action of light-regulated ligands for GPCRs and enzymes.<\/strong><\/p>\n<p><strong>Directors: <\/strong>Amadeu Llebaria (IQAC-CSIC) and Cyril Goudet\u00a0 (IGF-UM-CNRS, France)<\/p>\n<p>The thesis will be streamed in <a href=\"https:\/\/eu.bbcollab.com\/guest\/12797022a13c412ebd9c8e837971db5f\" target=\"_blank\" rel=\"noopener noreferrer\"><em><strong>this link<\/strong><\/em><\/a><\/p>\n<p><strong>Abstract<\/strong><\/p>\n<p><span style=\"font-family: Arial, serif;\"><span style=\"font-size: small;\">G Protein-Coupled Receptors (GPCRs), including the metabotropic glutamate 5 receptor <\/span><\/span><span style=\"color: #000000;\"><span style=\"font-family: Arial, serif;\"><span style=\"font-size: small;\">(mGlu<\/span><\/span><\/span><span style=\"color: #000000;\"><sub><span style=\"font-family: Arial, serif;\"><span style=\"font-size: small;\">5<\/span><\/span><\/sub><\/span><span style=\"color: #000000;\"><span style=\"font-family: Arial, serif;\"><span style=\"font-size: small;\">), are important therapeutic targets and the development of allosteric ligands targeting GPCRs has become a desirable approach toward modulating receptor activity. <\/span><\/span><\/span><span style=\"font-family: Arial, serif;\"><span style=\"font-size: small;\">Traditional pharmacological approaches toward modulating GPCR activity are still limited since precise spatiotemporal control of a ligand is lost as soon as it is administered. Photopharmacology proposes the use of photoswitchable ligands to overcome this limitation, since their activity can be reversibly controlled by light with high precision. As this is still a growing field, the molecular mechanisms underlying the light-induced changes of existing photoswitchable ligands are not well-understood and new light-regulated approaches can be useful to expand the toolbox of optical switches.<\/span><\/span><\/p>\n<p><span style=\"font-family: Arial, serif;\"><span style=\"font-size: small;\">We studied the mechanisms of action of alloswitch-1 and MCS0331, two freely diffusible mGlu<\/span><\/span><sub><span style=\"font-family: Arial, serif;\"><span style=\"font-size: small;\">5<\/span><\/span><\/sub> <span style=\"font-family: Arial, serif;\"><span style=\"font-size: small;\">photoswitchable negative allosteric modulators <\/span><\/span><span style=\"color: #111111;\"><span style=\"font-family: Arial, serif;\"><span style=\"font-size: small;\">(NAMs)<\/span><\/span><\/span><span style=\"font-family: Arial, serif;\"><span style=\"font-size: small;\">, through an innovative mass spectrometric (MS) binding methodology. <\/span><\/span><span style=\"color: #111111;\"><span style=\"font-family: Arial, serif;\"><span style=\"font-size: small;\">We developed and validated a highly sensitive, rapid and robust MS binding assay to quantify the binding of mGlu<\/span><\/span><\/span><span style=\"color: #111111;\"><sub><span style=\"font-family: Arial, serif;\"><span style=\"font-size: small;\">5<\/span><\/span><\/sub><\/span><span style=\"color: #111111;\"><span style=\"font-family: Arial, serif;\"><span style=\"font-size: small;\"> allosteric ligands. <\/span><\/span><\/span><span style=\"font-family: Arial, serif;\"><span style=\"font-size: small;\">This MS-based direct binding assay in combination with photochemical, cell-based, and <\/span><\/span><span style=\"font-family: Arial, serif;\"><span style=\"font-size: small;\"><i>in vivo<\/i><\/span><\/span><span style=\"font-family: Arial, serif;\"><span style=\"font-size: small;\"> photopharmacological approaches allowed then to investigate the effects of <\/span><\/span><span style=\"font-family: Arial, serif;\"><span style=\"font-size: small;\"><i>trans<\/i><\/span><\/span><span style=\"font-family: Arial, serif;\"><span style=\"font-size: small;\">-to-<\/span><\/span><span style=\"font-family: Arial, serif;\"><span style=\"font-size: small;\"><i>cis<\/i><\/span><\/span><span style=\"font-family: Arial, serif;\"><span style=\"font-size: small;\"> azobenzene photoisomerisation on the functional activity and binding ability of these ligands to the mGlu<\/span><\/span><sub><span style=\"font-family: Arial, serif;\"><span style=\"font-size: small;\">5<\/span><\/span><\/sub><span style=\"font-family: Arial, serif;\"><span style=\"font-size: small;\"> allosteric pocket.<\/span><\/span><span style=\"font-family: Arial, serif;\"><span style=\"font-size: small;\"><span lang=\"en-US\"> From these results, we conclude that photoisomerisation can take place inside and outside the ligand binding pocket, and this leads to a reversible loss in affinity, in part, due to changes in dissociation rates from the receptor. Ligand activity for both photoswitchable ligands deviates from high-affinity mGlu<\/span><\/span><\/span><sub><span style=\"font-family: Arial, serif;\"><span style=\"font-size: small;\"><span lang=\"en-US\">5<\/span><\/span><\/span><\/sub> <span style=\"font-family: Arial, serif;\"><span style=\"font-size: small;\"><span lang=\"en-US\">negative allosteric modulation (in the <\/span><\/span><\/span><span style=\"font-family: Arial, serif;\"><span style=\"font-size: small;\"><span lang=\"en-US\"><i>trans <\/i><\/span><\/span><\/span><span style=\"font-family: Arial, serif;\"><span style=\"font-size: small;\"><span lang=\"en-US\">configuration) to reduced affinity for the mGlu<\/span><\/span><\/span><sub><span style=\"font-family: Arial, serif;\"><span style=\"font-size: small;\"><span lang=\"en-US\">5<\/span><\/span><\/span><\/sub> <span style=\"font-family: Arial, serif;\"><span style=\"font-size: small;\"><span lang=\"en-US\">in their <\/span><\/span><\/span><span style=\"font-family: Arial, serif;\"><span style=\"font-size: small;\"><span lang=\"en-US\"><i>cis<\/i><\/span><\/span><\/span><span style=\"font-family: Arial, serif;\"><span style=\"font-size: small;\"><span lang=\"en-US\"> configuration. Importantly, this mechanism translates to dynamic and reversible control over pain following local injection and illumination of negative allosteric modulators into a brain region implicated in pain control. <\/span><\/span><\/span><\/p>\n<p><span style=\"font-family: Arial, serif;\"><span style=\"font-size: small;\"><span lang=\"en-GB\">A selective covalent labelling directed by the ligand affinity in a native protein was studied as an alternative approach to expand the toolbox of optical switches. The approach is based on obtaining an affinity label (AL) through a bioorthogonal reaction which contains a short-lived highly reactive anchoring group and the ligand. We designed non-photoswitchable and photoswitchable ALs to react with lysine residues exposed on the protein surface near the binding pocket. As a proof of concept, we selected Imiglucerase as target protein to be covalently modified. Among the obtained ALs, <\/span><\/span><\/span><span style=\"color: #000000;\"><span style=\"font-family: Arial, serif;\"><span style=\"font-size: small;\"><span lang=\"en-US\">AL 3 was formed using <\/span><\/span><\/span><\/span><span style=\"font-family: Arial, serif;\"><span style=\"font-size: small;\"><span lang=\"en-US\">a cooper-free click reaction and successfully labelled Imiglucerase. <\/span><\/span><\/span><span style=\"font-family: Arial, serif;\"><span style=\"font-size: small;\"><span lang=\"en-GB\">A proteomic assay following a bottom-up approach was then set up to verify the selectivity of the covalent modification. <\/span><\/span><\/span><span style=\"font-family: Arial, serif;\"><span style=\"font-size: small;\"><span lang=\"en-US\">The results obtained from non-labelled and labelled samples demonstrated the power of this approach to detect the desired peptide fragments. <\/span><\/span><\/span><span style=\"color: #111111;\"><span style=\"font-family: Arial, serif;\"><span style=\"font-size: small;\"><span lang=\"en-US\">Nevertheless, the preliminary data obtained indicated that<\/span><\/span><\/span><\/span><span style=\"font-family: Arial, serif;\"><span style=\"font-size: small;\"><span lang=\"en-US\"> the Imiglucerase was non-selectively labelled by AL 3 since <\/span><\/span><\/span><span style=\"font-family: Arial, serif;\"><span style=\"font-size: small;\"><span lang=\"en-US\">non-desired lysine residues were targeted. <\/span><\/span><\/span><span style=\"font-family: Arial, serif;\"><span style=\"font-size: small;\"><span lang=\"en-US\">Future experiments should be performed to verify the AL 3 labelling selectivity and to develop new <\/span><\/span><\/span><span style=\"color: #000000;\"><span style=\"font-family: Arial, serif;\"><span style=\"font-size: small;\"><span lang=\"en-US\">photoswitchable AL compounds.<\/span><\/span><\/span><\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>The Predoctoral Researcher Maria Ricart\u00a0from\u00a0Medicinal Chemistry &amp; Synthesis\u00a0(MCS) group is defending her thesis next\u00a0 4th December 2020\u00a0at\u00a010:00h. Title:\u00a0 Innovative tool to decipher the mode of action of light-regulated ligands for GPCRs and enzymes. Directors: Amadeu Llebaria (IQAC-CSIC) and Cyril Goudet\u00a0 (IGF-UM-CNRS, France) The thesis will be streamed in this link Abstract G Protein-Coupled Receptors (GPCRs),<a class=\"more-link\" href=\"https:\/\/www.iqac.csic.es\/en\/phd-thesis-defence-by-maria-ricart\/\">Continue reading <span class=\"screen-reader-text\">&#8220;PhD thesis defence by Maria Ricart&#8221;<\/span><\/a><\/p>\n","protected":false},"author":3,"featured_media":3625,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[70],"tags":[],"class_list":["post-7723","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news","entry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.7 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>PhD thesis defence by Maria Ricart | IQAC - Institut de Qu\u00edmica Avan\u00e7ada de Catalunya - CSIC<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.iqac.csic.es\/en\/phd-thesis-defence-by-maria-ricart\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"PhD thesis defence by Maria Ricart | IQAC - Institut de Qu\u00edmica Avan\u00e7ada de Catalunya - CSIC\" \/>\n<meta property=\"og:description\" content=\"The Predoctoral Researcher Maria Ricart\u00a0from\u00a0Medicinal Chemistry &amp; Synthesis\u00a0(MCS) group is defending her thesis next\u00a0 4th December 2020\u00a0at\u00a010:00h. Title:\u00a0 Innovative tool to decipher the mode of action of light-regulated ligands for GPCRs and enzymes. Directors: Amadeu Llebaria (IQAC-CSIC) and Cyril Goudet\u00a0 (IGF-UM-CNRS, France) The thesis will be streamed in this link Abstract G Protein-Coupled Receptors (GPCRs),Continue reading &quot;PhD thesis defence by Maria Ricart&quot;\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.iqac.csic.es\/en\/phd-thesis-defence-by-maria-ricart\/\" \/>\n<meta property=\"og:site_name\" content=\"IQAC - Institut de Qu\u00edmica Avan\u00e7ada de Catalunya - CSIC\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/iqac.csic.es\/\" \/>\n<meta property=\"article:published_time\" content=\"2020-11-30T09:29:09+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2026-06-16T09:11:08+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.iqac.csic.es\/wp-content\/uploads\/2026\/06\/Foto-Maria-Ricart-Ortega-web-IQAC.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"300\" \/>\n\t<meta property=\"og:image:height\" content=\"320\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Ana Sotres\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@IQAC_CSIC\" \/>\n<meta name=\"twitter:site\" content=\"@IQAC_CSIC\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Ana Sotres\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"3 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/www.iqac.csic.es\\\/en\\\/phd-thesis-defence-by-maria-ricart\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.iqac.csic.es\\\/en\\\/phd-thesis-defence-by-maria-ricart\\\/\"},\"author\":{\"name\":\"Ana Sotres\",\"@id\":\"https:\\\/\\\/www.iqac.csic.es\\\/#\\\/schema\\\/person\\\/ac65d00561d3a6d2810128c46771aff7\"},\"headline\":\"PhD thesis defence by Maria Ricart\",\"datePublished\":\"2020-11-30T09:29:09+00:00\",\"dateModified\":\"2026-06-16T09:11:08+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/www.iqac.csic.es\\\/en\\\/phd-thesis-defence-by-maria-ricart\\\/\"},\"wordCount\":536,\"publisher\":{\"@id\":\"https:\\\/\\\/www.iqac.csic.es\\\/#organization\"},\"image\":{\"@id\":\"https:\\\/\\\/www.iqac.csic.es\\\/en\\\/phd-thesis-defence-by-maria-ricart\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/www.iqac.csic.es\\\/wp-content\\\/uploads\\\/2026\\\/06\\\/Foto-Maria-Ricart-Ortega-web-IQAC.jpg\",\"articleSection\":[\"News\"],\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.iqac.csic.es\\\/en\\\/phd-thesis-defence-by-maria-ricart\\\/\",\"url\":\"https:\\\/\\\/www.iqac.csic.es\\\/en\\\/phd-thesis-defence-by-maria-ricart\\\/\",\"name\":\"PhD thesis defence by Maria Ricart | IQAC - Institut de Qu\u00edmica Avan\u00e7ada de Catalunya - CSIC\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.iqac.csic.es\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/www.iqac.csic.es\\\/en\\\/phd-thesis-defence-by-maria-ricart\\\/#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/www.iqac.csic.es\\\/en\\\/phd-thesis-defence-by-maria-ricart\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/www.iqac.csic.es\\\/wp-content\\\/uploads\\\/2026\\\/06\\\/Foto-Maria-Ricart-Ortega-web-IQAC.jpg\",\"datePublished\":\"2020-11-30T09:29:09+00:00\",\"dateModified\":\"2026-06-16T09:11:08+00:00\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/www.iqac.csic.es\\\/en\\\/phd-thesis-defence-by-maria-ricart\\\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/www.iqac.csic.es\\\/en\\\/phd-thesis-defence-by-maria-ricart\\\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/www.iqac.csic.es\\\/en\\\/phd-thesis-defence-by-maria-ricart\\\/#primaryimage\",\"url\":\"https:\\\/\\\/www.iqac.csic.es\\\/wp-content\\\/uploads\\\/2026\\\/06\\\/Foto-Maria-Ricart-Ortega-web-IQAC.jpg\",\"contentUrl\":\"https:\\\/\\\/www.iqac.csic.es\\\/wp-content\\\/uploads\\\/2026\\\/06\\\/Foto-Maria-Ricart-Ortega-web-IQAC.jpg\",\"width\":300,\"height\":320},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/www.iqac.csic.es\\\/en\\\/phd-thesis-defence-by-maria-ricart\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Portada\",\"item\":\"https:\\\/\\\/www.iqac.csic.es\\\/en\\\/home\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"PhD thesis defence by Maria Ricart\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/www.iqac.csic.es\\\/#website\",\"url\":\"https:\\\/\\\/www.iqac.csic.es\\\/\",\"name\":\"IQAC - Institut de Qu\u00edmica Avan\u00e7ada de Catalunya - CSIC\",\"description\":\"Chemistry for a better life\",\"publisher\":{\"@id\":\"https:\\\/\\\/www.iqac.csic.es\\\/#organization\"},\"alternateName\":\"IQAC - Institut de Qu\u00edmica Avan\u00e7ada de Catalunya - CSIC\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/www.iqac.csic.es\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Organization\",\"@id\":\"https:\\\/\\\/www.iqac.csic.es\\\/#organization\",\"name\":\"IQAC - Institut de Qu\u00edmica Avan\u00e7ada de Catalunya - CSIC\",\"alternateName\":\"IQAC - Institut de Qu\u00edmica Avan\u00e7ada de Catalunya - CSIC\",\"url\":\"https:\\\/\\\/www.iqac.csic.es\\\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/www.iqac.csic.es\\\/#\\\/schema\\\/logo\\\/image\\\/\",\"url\":\"https:\\\/\\\/www.iqac.csic.es\\\/wp-content\\\/uploads\\\/2025\\\/11\\\/cropped-favicon-1.png\",\"contentUrl\":\"https:\\\/\\\/www.iqac.csic.es\\\/wp-content\\\/uploads\\\/2025\\\/11\\\/cropped-favicon-1.png\",\"width\":512,\"height\":512,\"caption\":\"IQAC - Institut de Qu\u00edmica Avan\u00e7ada de Catalunya - CSIC\"},\"image\":{\"@id\":\"https:\\\/\\\/www.iqac.csic.es\\\/#\\\/schema\\\/logo\\\/image\\\/\"},\"sameAs\":[\"https:\\\/\\\/www.facebook.com\\\/iqac.csic.es\\\/\",\"https:\\\/\\\/x.com\\\/IQAC_CSIC\",\"https:\\\/\\\/www.instagram.com\\\/iqac_csic\",\"https:\\\/\\\/www.youtube.com\\\/channel\\\/UC1JXTOe3-s8UnYu_A6-SI3A\",\"https:\\\/\\\/www.linkedin.com\\\/company\\\/iqac-csic\\\/\"]},{\"@type\":\"Person\",\"@id\":\"https:\\\/\\\/www.iqac.csic.es\\\/#\\\/schema\\\/person\\\/ac65d00561d3a6d2810128c46771aff7\",\"name\":\"Ana Sotres\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/25826e5f3a7a258c44e58bdd075d81df4fb82260d2ac4db8eb7f8a34fe10b563?s=96&d=mm&r=g\",\"url\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/25826e5f3a7a258c44e58bdd075d81df4fb82260d2ac4db8eb7f8a34fe10b563?s=96&d=mm&r=g\",\"contentUrl\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/25826e5f3a7a258c44e58bdd075d81df4fb82260d2ac4db8eb7f8a34fe10b563?s=96&d=mm&r=g\",\"caption\":\"Ana Sotres\"},\"sameAs\":[\"https:\\\/\\\/www.iqac.csic.es\\\/\"]}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"PhD thesis defence by Maria Ricart | IQAC - Institut de Qu\u00edmica Avan\u00e7ada de Catalunya - CSIC","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.iqac.csic.es\/en\/phd-thesis-defence-by-maria-ricart\/","og_locale":"en_US","og_type":"article","og_title":"PhD thesis defence by Maria Ricart | IQAC - Institut de Qu\u00edmica Avan\u00e7ada de Catalunya - CSIC","og_description":"The Predoctoral Researcher Maria Ricart\u00a0from\u00a0Medicinal Chemistry &amp; Synthesis\u00a0(MCS) group is defending her thesis next\u00a0 4th December 2020\u00a0at\u00a010:00h. Title:\u00a0 Innovative tool to decipher the mode of action of light-regulated ligands for GPCRs and enzymes. Directors: Amadeu Llebaria (IQAC-CSIC) and Cyril Goudet\u00a0 (IGF-UM-CNRS, France) The thesis will be streamed in this link Abstract G Protein-Coupled Receptors (GPCRs),Continue reading \"PhD thesis defence by Maria Ricart\"","og_url":"https:\/\/www.iqac.csic.es\/en\/phd-thesis-defence-by-maria-ricart\/","og_site_name":"IQAC - Institut de Qu\u00edmica Avan\u00e7ada de Catalunya - CSIC","article_publisher":"https:\/\/www.facebook.com\/iqac.csic.es\/","article_published_time":"2020-11-30T09:29:09+00:00","article_modified_time":"2026-06-16T09:11:08+00:00","og_image":[{"width":300,"height":320,"url":"https:\/\/www.iqac.csic.es\/wp-content\/uploads\/2026\/06\/Foto-Maria-Ricart-Ortega-web-IQAC.jpg","type":"image\/jpeg"}],"author":"Ana Sotres","twitter_card":"summary_large_image","twitter_creator":"@IQAC_CSIC","twitter_site":"@IQAC_CSIC","twitter_misc":{"Written by":"Ana Sotres","Est. reading time":"3 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/www.iqac.csic.es\/en\/phd-thesis-defence-by-maria-ricart\/#article","isPartOf":{"@id":"https:\/\/www.iqac.csic.es\/en\/phd-thesis-defence-by-maria-ricart\/"},"author":{"name":"Ana Sotres","@id":"https:\/\/www.iqac.csic.es\/#\/schema\/person\/ac65d00561d3a6d2810128c46771aff7"},"headline":"PhD thesis defence by Maria Ricart","datePublished":"2020-11-30T09:29:09+00:00","dateModified":"2026-06-16T09:11:08+00:00","mainEntityOfPage":{"@id":"https:\/\/www.iqac.csic.es\/en\/phd-thesis-defence-by-maria-ricart\/"},"wordCount":536,"publisher":{"@id":"https:\/\/www.iqac.csic.es\/#organization"},"image":{"@id":"https:\/\/www.iqac.csic.es\/en\/phd-thesis-defence-by-maria-ricart\/#primaryimage"},"thumbnailUrl":"https:\/\/www.iqac.csic.es\/wp-content\/uploads\/2026\/06\/Foto-Maria-Ricart-Ortega-web-IQAC.jpg","articleSection":["News"],"inLanguage":"en-US"},{"@type":"WebPage","@id":"https:\/\/www.iqac.csic.es\/en\/phd-thesis-defence-by-maria-ricart\/","url":"https:\/\/www.iqac.csic.es\/en\/phd-thesis-defence-by-maria-ricart\/","name":"PhD thesis defence by Maria Ricart | IQAC - Institut de Qu\u00edmica Avan\u00e7ada de Catalunya - CSIC","isPartOf":{"@id":"https:\/\/www.iqac.csic.es\/#website"},"primaryImageOfPage":{"@id":"https:\/\/www.iqac.csic.es\/en\/phd-thesis-defence-by-maria-ricart\/#primaryimage"},"image":{"@id":"https:\/\/www.iqac.csic.es\/en\/phd-thesis-defence-by-maria-ricart\/#primaryimage"},"thumbnailUrl":"https:\/\/www.iqac.csic.es\/wp-content\/uploads\/2026\/06\/Foto-Maria-Ricart-Ortega-web-IQAC.jpg","datePublished":"2020-11-30T09:29:09+00:00","dateModified":"2026-06-16T09:11:08+00:00","breadcrumb":{"@id":"https:\/\/www.iqac.csic.es\/en\/phd-thesis-defence-by-maria-ricart\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.iqac.csic.es\/en\/phd-thesis-defence-by-maria-ricart\/"]}]},{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.iqac.csic.es\/en\/phd-thesis-defence-by-maria-ricart\/#primaryimage","url":"https:\/\/www.iqac.csic.es\/wp-content\/uploads\/2026\/06\/Foto-Maria-Ricart-Ortega-web-IQAC.jpg","contentUrl":"https:\/\/www.iqac.csic.es\/wp-content\/uploads\/2026\/06\/Foto-Maria-Ricart-Ortega-web-IQAC.jpg","width":300,"height":320},{"@type":"BreadcrumbList","@id":"https:\/\/www.iqac.csic.es\/en\/phd-thesis-defence-by-maria-ricart\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Portada","item":"https:\/\/www.iqac.csic.es\/en\/home\/"},{"@type":"ListItem","position":2,"name":"PhD thesis defence by Maria Ricart"}]},{"@type":"WebSite","@id":"https:\/\/www.iqac.csic.es\/#website","url":"https:\/\/www.iqac.csic.es\/","name":"IQAC - Institut de Qu\u00edmica Avan\u00e7ada de Catalunya - CSIC","description":"Chemistry for a better life","publisher":{"@id":"https:\/\/www.iqac.csic.es\/#organization"},"alternateName":"IQAC - Institut de Qu\u00edmica Avan\u00e7ada de Catalunya - CSIC","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.iqac.csic.es\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Organization","@id":"https:\/\/www.iqac.csic.es\/#organization","name":"IQAC - Institut de Qu\u00edmica Avan\u00e7ada de Catalunya - CSIC","alternateName":"IQAC - Institut de Qu\u00edmica Avan\u00e7ada de Catalunya - CSIC","url":"https:\/\/www.iqac.csic.es\/","logo":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.iqac.csic.es\/#\/schema\/logo\/image\/","url":"https:\/\/www.iqac.csic.es\/wp-content\/uploads\/2025\/11\/cropped-favicon-1.png","contentUrl":"https:\/\/www.iqac.csic.es\/wp-content\/uploads\/2025\/11\/cropped-favicon-1.png","width":512,"height":512,"caption":"IQAC - Institut de Qu\u00edmica Avan\u00e7ada de Catalunya - CSIC"},"image":{"@id":"https:\/\/www.iqac.csic.es\/#\/schema\/logo\/image\/"},"sameAs":["https:\/\/www.facebook.com\/iqac.csic.es\/","https:\/\/x.com\/IQAC_CSIC","https:\/\/www.instagram.com\/iqac_csic","https:\/\/www.youtube.com\/channel\/UC1JXTOe3-s8UnYu_A6-SI3A","https:\/\/www.linkedin.com\/company\/iqac-csic\/"]},{"@type":"Person","@id":"https:\/\/www.iqac.csic.es\/#\/schema\/person\/ac65d00561d3a6d2810128c46771aff7","name":"Ana Sotres","image":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/secure.gravatar.com\/avatar\/25826e5f3a7a258c44e58bdd075d81df4fb82260d2ac4db8eb7f8a34fe10b563?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/25826e5f3a7a258c44e58bdd075d81df4fb82260d2ac4db8eb7f8a34fe10b563?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/25826e5f3a7a258c44e58bdd075d81df4fb82260d2ac4db8eb7f8a34fe10b563?s=96&d=mm&r=g","caption":"Ana Sotres"},"sameAs":["https:\/\/www.iqac.csic.es\/"]}]}},"_links":{"self":[{"href":"https:\/\/www.iqac.csic.es\/en\/wp-json\/wp\/v2\/posts\/7723","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.iqac.csic.es\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.iqac.csic.es\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.iqac.csic.es\/en\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/www.iqac.csic.es\/en\/wp-json\/wp\/v2\/comments?post=7723"}],"version-history":[{"count":1,"href":"https:\/\/www.iqac.csic.es\/en\/wp-json\/wp\/v2\/posts\/7723\/revisions"}],"predecessor-version":[{"id":8575,"href":"https:\/\/www.iqac.csic.es\/en\/wp-json\/wp\/v2\/posts\/7723\/revisions\/8575"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.iqac.csic.es\/en\/wp-json\/wp\/v2\/media\/3625"}],"wp:attachment":[{"href":"https:\/\/www.iqac.csic.es\/en\/wp-json\/wp\/v2\/media?parent=7723"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.iqac.csic.es\/en\/wp-json\/wp\/v2\/categories?post=7723"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.iqac.csic.es\/en\/wp-json\/wp\/v2\/tags?post=7723"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}