{"id":7831,"date":"2022-04-21T07:21:31","date_gmt":"2022-04-21T05:21:31","guid":{"rendered":"https:\/\/www.iqac.csic.es\/the-coming-revolution-synthetic-dna-and-rna-for-therapeutic-and-diagnostic-applications\/"},"modified":"2026-06-16T11:11:16","modified_gmt":"2026-06-16T09:11:16","slug":"the-coming-revolution-synthetic-dna-and-rna-for-therapeutic-and-diagnostic-applications","status":"publish","type":"post","link":"https:\/\/www.iqac.csic.es\/en\/the-coming-revolution-synthetic-dna-and-rna-for-therapeutic-and-diagnostic-applications\/","title":{"rendered":"The coming revolution: synthetic DNA and RNA for therapeutic and diagnostic applications"},"content":{"rendered":"<p>The discovery of the mRNA vaccines for the treatment of coronavirus, as well as new medicines for the treatment of genetic diseases, has been important in the quest of solutions for undrugable diseases in an unexpected short-time.<\/p>\n<p>Thus, the chemical modifications of nucleic acids with diagnostic and therapeutic purposes is now a reality, a revolution that promises to give hopes on unsolved medical problems or optimize previous approaches, largely due to the research push for the development of mRNA vaccines against SARS-CoV-2 infection.<\/p>\n<p>Now, the prestigious <strong>\u201c<\/strong><a href=\"https:\/\/doi.org\/10.1002\/tcr.202100270\" target=\"_blank\" rel=\"noopener\"><strong>The Chemical Record<\/strong><\/a><strong>\u201d<\/strong> journal has invited the <a href=\"https:\/\/www.iqac.csic.es\/research\/departments\/surfactants-and-nanobiotechnology\/nucleic-acids-chemistry\/\" target=\"_blank\" rel=\"noopener\"><strong>Nucleic Acids Chemistry<\/strong><\/a> group, of IQAC and CIBER-BBN and belonging to the<a href=\"https:\/\/pti-saludglobal-covid19.corp.csic.es\/\" target=\"_blank\" rel=\"noopener\"> Global Health Platform<\/a> of CSIC, to describe the advances and modificacions of the nucleic acids in the last decade. The article, authored by <strong>Dr. Carme F\u00e0brega<\/strong>, <strong>Dr.<\/strong> <strong>Anna Avi\u00f1\u00f3<\/strong> and <strong>Dr. Ramon Eritja <\/strong>(coordinator and director, respectively, of Unidad 29 of <a href=\"https:\/\/www.nanbiosis.es\/\">ICTS NANBIOSIS<\/a>), reports the development of synthetic DNA and RNA for therapeutic and diagnostic applications.<\/p>\n<p>The article describes the most important results from the <strong>Nucleic Acid Chemistry group<\/strong> in this area covering the international context that surrounded these studies. These include the development of modifications in <strong>potentially therapeutic oligonucleotides <\/strong>to enhance nuclease resistance as well as improving cellular uptake and avoiding side effects, and the advances in the use of DNA nanostructures in the controlled deposition of matter in surfaces and their potential application as drug delivery systems is reported.<\/p>\n<p>Moreover, the article has been selected to illustrate the <strong>front cover<\/strong> of <strong>The Chemical Record<\/strong> journal, with a suggestive image that shows the research activity in this area. The back image is the three dimensional reconstruction of a DNA array described by the group of <strong>Dr. Seeman <\/strong>obtained by A. Garibotti in Barcelona. On the top the crystal structure of the Argonaute protein from the Protein Data Bank is shown. This protein is a natural player that helps the therapeutic action of RNA molecules.<\/p>\n<p>Read the full article <a href=\"https:\/\/doi.org\/10.1002\/tcr.202100270\" target=\"_blank\" rel=\"noopener\"><em>in this link<\/em><\/a><em>.<\/em><\/p>\n<p><a href=\"http:\/\/www.iqac.csic.es\/wp-content\/uploads\/2022\/04\/tcr202280401-toc-0001-m.jpg\"><\/a><\/p>\n<p style=\"text-align: right;\"><strong>IQAC-CSIC Communication<\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"<p>The discovery of the mRNA vaccines for the treatment of coronavirus, as well as new medicines for the treatment of genetic diseases, has been important in the quest of solutions for undrugable diseases in an unexpected short-time. Thus, the chemical modifications of nucleic acids with diagnostic and therapeutic purposes is now a reality, a revolution<a class=\"more-link\" href=\"https:\/\/www.iqac.csic.es\/en\/the-coming-revolution-synthetic-dna-and-rna-for-therapeutic-and-diagnostic-applications\/\">Continue reading <span class=\"screen-reader-text\">&#8220;The coming revolution: synthetic DNA and RNA for therapeutic and diagnostic applications&#8221;<\/span><\/a><\/p>\n","protected":false},"author":3,"featured_media":3808,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[70],"tags":[],"class_list":["post-7831","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news","entry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.7 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>The coming revolution: synthetic DNA and RNA for therapeutic and diagnostic applications | IQAC - Institut de Qu\u00edmica Avan\u00e7ada de Catalunya - CSIC<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.iqac.csic.es\/en\/the-coming-revolution-synthetic-dna-and-rna-for-therapeutic-and-diagnostic-applications\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"The coming revolution: synthetic DNA and RNA for therapeutic and diagnostic applications | IQAC - Institut de Qu\u00edmica Avan\u00e7ada de Catalunya - CSIC\" \/>\n<meta property=\"og:description\" content=\"The discovery of the mRNA vaccines for the treatment of coronavirus, as well as new medicines for the treatment of genetic diseases, has been important in the quest of solutions for undrugable diseases in an unexpected short-time. Thus, the chemical modifications of nucleic acids with diagnostic and therapeutic purposes is now a reality, a revolutionContinue reading &quot;The coming revolution: synthetic DNA and RNA for therapeutic and diagnostic applications&quot;\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.iqac.csic.es\/en\/the-coming-revolution-synthetic-dna-and-rna-for-therapeutic-and-diagnostic-applications\/\" \/>\n<meta property=\"og:site_name\" content=\"IQAC - Institut de Qu\u00edmica Avan\u00e7ada de Catalunya - CSIC\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/iqac.csic.es\/\" \/>\n<meta property=\"article:published_time\" content=\"2022-04-21T05:21:31+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2026-06-16T09:11:16+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.iqac.csic.es\/wp-content\/uploads\/2026\/06\/Nucleic_Acid_Chemistry.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1037\" \/>\n\t<meta property=\"og:image:height\" content=\"691\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Ana Sotres\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@IQAC_CSIC\" \/>\n<meta name=\"twitter:site\" content=\"@IQAC_CSIC\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Ana Sotres\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/www.iqac.csic.es\\\/en\\\/the-coming-revolution-synthetic-dna-and-rna-for-therapeutic-and-diagnostic-applications\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.iqac.csic.es\\\/en\\\/the-coming-revolution-synthetic-dna-and-rna-for-therapeutic-and-diagnostic-applications\\\/\"},\"author\":{\"name\":\"Ana Sotres\",\"@id\":\"https:\\\/\\\/www.iqac.csic.es\\\/#\\\/schema\\\/person\\\/ac65d00561d3a6d2810128c46771aff7\"},\"headline\":\"The coming revolution: synthetic DNA and RNA for therapeutic and diagnostic applications\",\"datePublished\":\"2022-04-21T05:21:31+00:00\",\"dateModified\":\"2026-06-16T09:11:16+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/www.iqac.csic.es\\\/en\\\/the-coming-revolution-synthetic-dna-and-rna-for-therapeutic-and-diagnostic-applications\\\/\"},\"wordCount\":341,\"publisher\":{\"@id\":\"https:\\\/\\\/www.iqac.csic.es\\\/#organization\"},\"image\":{\"@id\":\"https:\\\/\\\/www.iqac.csic.es\\\/en\\\/the-coming-revolution-synthetic-dna-and-rna-for-therapeutic-and-diagnostic-applications\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/www.iqac.csic.es\\\/wp-content\\\/uploads\\\/2026\\\/06\\\/Nucleic_Acid_Chemistry.jpg\",\"articleSection\":[\"News\"],\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.iqac.csic.es\\\/en\\\/the-coming-revolution-synthetic-dna-and-rna-for-therapeutic-and-diagnostic-applications\\\/\",\"url\":\"https:\\\/\\\/www.iqac.csic.es\\\/en\\\/the-coming-revolution-synthetic-dna-and-rna-for-therapeutic-and-diagnostic-applications\\\/\",\"name\":\"The coming revolution: synthetic DNA and RNA for therapeutic and diagnostic applications | IQAC - 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