{"id":7950,"date":"2024-10-09T08:04:26","date_gmt":"2024-10-09T06:04:26","guid":{"rendered":"https:\/\/www.iqac.csic.es\/nanotechnology-to-slow-down-the-growth-of-glioblastomas\/"},"modified":"2026-06-16T11:11:21","modified_gmt":"2026-06-16T09:11:21","slug":"nanotechnology-to-slow-down-the-growth-of-glioblastomas","status":"publish","type":"post","link":"https:\/\/www.iqac.csic.es\/en\/nanotechnology-to-slow-down-the-growth-of-glioblastomas\/","title":{"rendered":"Nanotechnology to slow down the growth of glioblastomas"},"content":{"rendered":"<p>Each year, on October 9th, <strong>Nanotechnology Day<\/strong> is celebrated, a discipline dedicated to understanding and utilizing matter at a nanometric scale for purposes such as industrial or medical applications. Nanotechnology plays a fundamental role in many research lines developed at the <strong>Institute for Advanced Chemistry of Catalonia<\/strong> (<a href=\"https:\/\/www.iqac.csic.es\/\" target=\"_blank\" rel=\"noopener\">IQAC-CSIC<\/a>).<\/p>\n<p>One of the standout projects in this area is the <strong>ReachGlio<\/strong> project, which focuses on improving drug delivery designed to slow the growth of glioblastomas using multifunctional nanomedicines. \u201cOur goal is to propose one or more clinical trials in patients with glioblastoma using nanomedicines that can efficiently reach the brain and have antitumor activity,\u201d explains Ibane Abasolo, the project\u2019s principal investigator.<\/p>\n<p>ReachGlio is part of the <strong>TRANSCAN 3<\/strong> program, involving seven European entities, including two Spanish institutions: the <strong>Instituto de Salud Carlos III<\/strong> (<a href=\"https:\/\/www.isciii.es\/\" target=\"_blank\" rel=\"noopener\">ISCIII<\/a>) and the <strong>Biomedical Research Networking Center in Bioengineering, Biomaterials, and Nanomedicine<\/strong> (<a href=\"https:\/\/www.ciber-bbn.es\/\" target=\"_blank\" rel=\"noopener\">CIBER-BBN<\/a>). The <strong>Institute for Advanced Chemistry of Catalonia<\/strong> (<a href=\"https:\/\/www.iqac.csic.es\/\" target=\"_blank\" rel=\"noopener\">IQAC-CSIC<\/a>) participates through the CIBER-BBN groups led by researchers Miriam Royo and Ibane Abasolo.<\/p>\n<h5><strong>Nanomedicines with antitumor activity<\/strong><\/h5>\n<p>Glioblastomas are among the most aggressive tumors due to their location within the brain and their ability to invade surrounding tissue. Additionally, they are highly heterogeneous tumors. All of this explains why the prognosis for patients with this type of tumor remains very poor, with no curative therapy options available.<\/p>\n<p>&#8220;One of the main challenges for drugs designed to slow the growth of glioblastomas is how difficult it is for them to effectively reach the brain and distribute homogeneously within such a diverse tumor,&#8221; explains <strong>Miriam Royo<\/strong>, researcher of the project.<\/p>\n<p>To overcome this obstacle, the current project proposes <strong>the use of nanoparticles that <\/strong><strong>incorporate existing drugs<\/strong>, which, although they have already proven capable of slowing tumor cells, have difficulty accessing the brain. These nanoparticles, specifically polymeric micelles, have small peptide sequences on their surface that act as targeting molecules. These peptides help the nanoparticles cross the blood-brain barrier, between the blood vessels and the brain, and once inside the brain, they guide them towards the tumor cells.<\/p>\n<p>During the project, a drug (NGR-TNF) will also be tested, which makes the blood-brain barrier more permeable, in combination with antitumor treatments or the nanomedicines being developed. \u201cThis specific part is planned to be tested at the veterinary level in dogs that already suffer from spontaneous brain tumors, so we hope the project&#8217;s results can quickly reach glioblastoma patients,\u201d adds <strong>Ibane Abasolo<\/strong>.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Each year, on October 9th, Nanotechnology Day is celebrated, a discipline dedicated to understanding and utilizing matter at a nanometric scale for purposes such as industrial or medical applications. Nanotechnology plays a fundamental role in many research lines developed at the Institute for Advanced Chemistry of Catalonia (IQAC-CSIC). One of the standout projects in this<a class=\"more-link\" href=\"https:\/\/www.iqac.csic.es\/en\/nanotechnology-to-slow-down-the-growth-of-glioblastomas\/\">Continue reading <span class=\"screen-reader-text\">&#8220;Nanotechnology to slow down the growth of glioblastomas&#8221;<\/span><\/a><\/p>\n","protected":false},"author":3,"featured_media":3996,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[70],"tags":[],"class_list":["post-7950","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news","entry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.7 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Nanotechnology to slow down the growth of glioblastomas | IQAC - Institut de Qu\u00edmica Avan\u00e7ada de Catalunya - CSIC<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.iqac.csic.es\/en\/nanotechnology-to-slow-down-the-growth-of-glioblastomas\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Nanotechnology to slow down the growth of glioblastomas | IQAC - Institut de Qu\u00edmica Avan\u00e7ada de Catalunya - CSIC\" \/>\n<meta property=\"og:description\" content=\"Each year, on October 9th, Nanotechnology Day is celebrated, a discipline dedicated to understanding and utilizing matter at a nanometric scale for purposes such as industrial or medical applications. Nanotechnology plays a fundamental role in many research lines developed at the Institute for Advanced Chemistry of Catalonia (IQAC-CSIC). 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