{"id":8005,"date":"2025-10-07T08:05:49","date_gmt":"2025-10-07T06:05:49","guid":{"rendered":"https:\/\/www.iqac.csic.es\/researchers-discover-a-compound-that-could-change-the-treatment-of-traumatic-brain-injuries\/"},"modified":"2026-06-16T11:11:23","modified_gmt":"2026-06-16T09:11:23","slug":"researchers-discover-a-compound-that-could-change-the-treatment-of-traumatic-brain-injuries","status":"publish","type":"post","link":"https:\/\/www.iqac.csic.es\/en\/researchers-discover-a-compound-that-could-change-the-treatment-of-traumatic-brain-injuries\/","title":{"rendered":"Researchers discover a compound that could change the treatment of traumatic brain injuries"},"content":{"rendered":"

An international team of scientists, including researchers from the Institute for Advanced Chemistry of Catalonia (IQAC)<\/a> of the Spanish National Research Council (CSIC)<\/a>, an institution under the Ministry of Science, Innovation and Universities, has discovered that a small compound\u2014a peptide made up of four amino acids called CAQK\u2014has a significant neuroprotective effect in mouse models of traumatic brain injury.<\/p>\n

When administered intravenously shortly after injury in animal models (mice and pigs), CAQK specifically targets the damaged areas of the brain, attracted by a protein that is overexpressed in injured tissue following trauma. CAQK accumulates in the region marked by this protein and is able to reduce inflammation, cell death, and damage to brain tissue. Moreover, in mice, it improved functional recovery without apparent toxicity.<\/p>\n

The results, published in the journal EMBO Molecular Medicine<\/em>, open new possibilities for treating injured areas of the brain. The study was led by the company Aivocode<\/a> (a spin-off of the Sanford Burnham Prebys Institute<\/a>) in San Diego, California, in collaboration with the Institute for Advanced Chemistry of Catalonia (IQAC-CSIC) and the University of California, Davis<\/a>.<\/p>\n

Aivocode, founded by researchers Aman P. Mann, Sazid Hussain, and Erkki Ruoslahti (authors of the study), plans to soon seek authorization from the U.S. Food and Drug Administration (FDA) to begin Phase I clinical trials in humans. Although no specific date has been set, the fact that CAQK is a short peptide\u2014easy to produce and with good tissue penetration\u2014makes it a strong candidate for drug development.<\/p>\n

Traumatic Brain Injury<\/strong><\/h5>\n

Traumatic brain injury (TBI) is brain damage typically caused by blows to the head, such as those resulting from traffic accidents, workplace incidents, or falls. It is estimated to affect around 200 people per 100,000 inhabitants each year. Currently, treatment focuses on stabilizing the patient by reducing intracranial pressure and maintaining blood flow, but there are no approved drugs to halt brain damage or its secondary effects, such as inflammation or cell death. In addition, the therapies under investigation require direct injections into the brain, an invasive technique that can cause complications.<\/p>\n

\u201cThe current interventions for treating acute brain injury aim to stabilize the patient by reducing intracranial pressure and maintaining blood flow, but there are no approved drugs to stop the damage and secondary effects of these injuries,\u201d explains Dr. Pablo Scodeller<\/strong>, researcher at IQAC-CSIC and co-author of the study.<\/p><\/blockquote>\n

The Great Challenge of Neurology<\/strong><\/h5>\n

Finding a non-invasive way to treat an injured brain is one of the major challenges in neurology. This study moves in that direction, building on previous work carried out by the researchers in 2016 and published in Nature Communications<\/a>.<\/p>\n

At that time, researcher Aman P. Mann, together with Pablo Scodeller, working in the laboratory of Dr. Ruoslahti (senior author of both studies) at Sanford Burnham Prebys, discovered a peptide\u2014a small chain of amino acids, the building blocks of proteins\u2014that specifically targeted injured areas of the brain in mice. The peptide, named CAQK, was identified through a large-scale screening technique known as peptide-phage display<\/em>, which allows the selection of molecules with affinity for specific tissues. In that earlier study, CAQK was used as a \u201cvehicle\u201d to deliver drugs directly to the damaged area. However, in their new work, the researchers went a step further and demonstrated that the CAQK peptide itself has therapeutic effects.<\/p>\n

To evaluate its therapeutic activity, the peptide was first administered intravenously shortly after a moderate or severe traumatic brain injury, and it was observed that the peptide accumulated in the injured brains of mice and pigs (the latter having brains more similar to humans than mice). Furthermore, it was found that the peptide binds to special molecules called glycoproteins (proteins attached to sugars), which become more abundant after an injury and are part of the extracellular matrix\u2014a supporting network that surrounds brain cells.<\/p>\n

Treatment of mice with traumatic brain injury using this peptide resulted in a reduction in lesion size compared to control mice. \u201cWe observed less cell death and lower expression of inflammatory markers in the injured area, indicating that CAQK alleviated neuroinflammation and its secondary effects. Behavioral and memory tests conducted after treatment also showed improvement in functional deficits, with no evident toxicity,\u201d explains the study\u2019s first author, Dr. Mann<\/strong>.<\/p>\n

The study\u2019s results demonstrate that the CAQK peptide can help repair the damaged area, highlighting its potential therapeutic applications following trauma. \u201cWhat\u2019s exciting is that, in addition to proving highly effective, it\u2019s a very simple compound\u2014a short peptide that is easy to synthesize safely at large scale. Peptides with these characteristics show good tissue penetration and are non-immunogenic,\u201d concludes Scodeller<\/strong>.<\/p>\n

 <\/p>\n

Mann AP, Hussain S, Scodeller P, Moore HNB, Sherazee E, Russo RM, Ruoslahti E. A neuroprotective tetrapeptide for treatment of acute traumatic brain injury<\/strong>. EMBO Mol Med. 2025 doi: 10.1038\/s44321-025-00312-5<\/a><\/p>\n

 <\/p>\n","protected":false},"excerpt":{"rendered":"

An international team of scientists, including researchers from the Institute for Advanced Chemistry of Catalonia (IQAC) of the Spanish National Research Council (CSIC), an institution under the Ministry of Science, Innovation and Universities, has discovered that a small compound\u2014a peptide made up of four amino acids called CAQK\u2014has a significant neuroprotective effect in mouse modelsContinue reading “Researchers discover a compound that could change the treatment of traumatic brain injuries”<\/span><\/a><\/p>\n","protected":false},"author":3,"featured_media":4073,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[70],"tags":[],"class_list":["post-8005","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news","entry"],"acf":[],"yoast_head":"\nResearchers discover a compound that could change the treatment of traumatic brain injuries | IQAC - 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