{"id":11026,"date":"2026-06-19T11:06:24","date_gmt":"2026-06-19T09:06:24","guid":{"rendered":"https:\/\/www.iqac.csic.es\/proyecto\/harnessing-aldh-enzyme-activity-to-develop-highly-selective-drugs-against-cancer-stem-cells\/"},"modified":"2026-06-19T11:06:24","modified_gmt":"2026-06-19T09:06:24","slug":"harnessing-aldh-enzyme-activity-to-develop-highly-selective-drugs-against-cancer-stem-cells","status":"publish","type":"proyecto","link":"https:\/\/www.iqac.csic.es\/en\/project\/harnessing-aldh-enzyme-activity-to-develop-highly-selective-drugs-against-cancer-stem-cells\/","title":{"rendered":"Harnessing ALDH enzyme activity to develop highly selective drugs against cancer stem cells"},"content":{"rendered":"<p class=\"p1\">Accumulating evidence reinforces the theory that cancer is developed and maintained by a subpopulation of cancer cells with stem cell properties. These cancer stem cells (CSCs) are typically in a quiescent state, making them resistant to standard therapies and responsible for disease relapse. The ERC-funded SeleCStem project aims to develop innovative strategies to target CSCs effectively by exploiting the enzyme aldehyde dehydrogenase (ALDH), which is overexpressed in CSCs across various cancers. The research team will harness the enzyme\u2019s activity to selectively release drugs within CSCs and combine it with light-mediated inhibition of ALDH in tumours.   <\/p>\n","protected":false},"excerpt":{"rendered":"<p>SeleCStem aims to target the cancer stem cells responsible for therapy resistance and relapse. It will harness ALDH activity to deliver drugs selectively and inhibit tumours using light. <\/p>\n","protected":false},"featured_media":11027,"parent":0,"template":"","meta":{"_acf_changed":false},"tags":[174,173],"enfermedad":[171],"framework":[128],"linea-de-investigacion":[172],"class_list":["post-11026","proyecto","type-proyecto","status-publish","has-post-thumbnail","hentry","tag-drug-discovery","tag-medicinal-chemistry","enfermedad-cancer","framework-horizon-europe","linea-de-investigacion-treat","entry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.7 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Harnessing ALDH enzyme activity to develop highly selective drugs against cancer stem cells | IQAC - Institut de Qu\u00edmica Avan\u00e7ada de Catalunya - CSIC<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.iqac.csic.es\/en\/project\/harnessing-aldh-enzyme-activity-to-develop-highly-selective-drugs-against-cancer-stem-cells\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Harnessing ALDH enzyme activity to develop highly selective drugs against cancer stem cells | IQAC - Institut de Qu\u00edmica Avan\u00e7ada de Catalunya - CSIC\" \/>\n<meta property=\"og:description\" content=\"SeleCStem aims to target the cancer stem cells responsible for therapy resistance and relapse. 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