{"id":11066,"date":"2026-07-07T13:10:41","date_gmt":"2026-07-07T11:10:41","guid":{"rendered":"https:\/\/www.iqac.csic.es\/proyecto\/toxicological-testing-platform-integrating-immunocompetent-in-vitro-ex-vivo-modules-with-real-time-sensors-and-machine-learning-based-in-silico-models-for-life-cycle-assessment-and-the-ssbd-approach\/"},"modified":"2026-07-07T13:10:41","modified_gmt":"2026-07-07T11:10:41","slug":"toxicological-testing-platform-integrating-immunocompetent-in-vitro-ex-vivo-modules-with-real-time-sensors-and-machine-learning-based-in-silico-models-for-life-cycle-assessment-and-the-ssbd-approach","status":"publish","type":"proyecto","link":"https:\/\/www.iqac.csic.es\/en\/project\/toxicological-testing-platform-integrating-immunocompetent-in-vitro-ex-vivo-modules-with-real-time-sensors-and-machine-learning-based-in-silico-models-for-life-cycle-assessment-and-the-ssbd-approach\/","title":{"rendered":"Toxicological testing platform integrating immunocompetent in vitro\/ex vivo modules with real-time sensors and machine learning-based in silico models for life cycle assessment and the SSbD approach"},"content":{"rendered":"<p>New potentially toxic chemicals and materials require strict safety assessments to comply with health and regulatory requirements. This relies heavily on <em>in vivo<\/em> studies, which are unable to fully address potential toxicity, while also omitting environmental aspects and life cycle assessment. <\/p>\n<p>TOXBOX seeks a solution to the limitations in chemical toxicity assessment through a modular, integrated, and ergonomic tool for safety and sustainability evaluation, with <em>high throughput<\/em> and predictive capacity. Building on a prototype developed in a previous EC-funded project (PANBioRA), a microfluidic system will be developed that will incorporate electrochemical sensors, microscopes\/cameras, and cytokine measurement. <\/p>\n<p>The intelligent combination of <em>in vitro<\/em> assays and <em>in silico<\/em> modeling will result in a system capable of better predicting human and environmental safety and providing a more accurate understanding of short- and long-term toxic effects.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>The &#8220;Safe and Sustainable by Design&#8221; approach requires monitoring throughout the entire life cycle of chemicals. TOXBOX aims to develop an instrument that provides reliable toxicity data under relevant conditions and enables the development of reliable in silico models. <\/p>\n","protected":false},"featured_media":11067,"parent":0,"template":"","meta":{"_acf_changed":false},"tags":[182,166],"enfermedad":[],"framework":[128],"linea-de-investigacion":[181,163],"class_list":["post-11066","proyecto","type-proyecto","status-publish","has-post-thumbnail","hentry","tag-nanobiotechnology","tag-one-health","framework-horizon-europe","linea-de-investigacion-detect","linea-de-investigacion-understand","entry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.7 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Toxicological testing platform integrating immunocompetent in vitro\/ex vivo modules with real-time sensors and machine learning-based in silico models for life cycle assessment and the SSbD approach | IQAC - Institut de Qu\u00edmica Avan\u00e7ada de Catalunya - CSIC<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.iqac.csic.es\/en\/project\/toxicological-testing-platform-integrating-immunocompetent-in-vitro-ex-vivo-modules-with-real-time-sensors-and-machine-learning-based-in-silico-models-for-life-cycle-assessment-and-the-ssbd-approach\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Toxicological testing platform integrating immunocompetent in vitro\/ex vivo modules with real-time sensors and machine learning-based in silico models for life cycle assessment and the SSbD approach | IQAC - Institut de Qu\u00edmica Avan\u00e7ada de Catalunya - CSIC\" \/>\n<meta property=\"og:description\" content=\"The &quot;Safe and Sustainable by Design&quot; approach requires monitoring throughout the entire life cycle of chemicals. 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