{"id":11072,"date":"2026-07-07T12:45:25","date_gmt":"2026-07-07T10:45:25","guid":{"rendered":"https:\/\/www.iqac.csic.es\/proyecto\/photoimmunomodulation-in-glioblastoma-using-peptide-photosensitizer-conjugates\/"},"modified":"2026-07-07T12:45:25","modified_gmt":"2026-07-07T10:45:25","slug":"photoimmunomodulation-in-glioblastoma-using-peptide-photosensitizer-conjugates","status":"publish","type":"proyecto","link":"https:\/\/www.iqac.csic.es\/en\/project\/photoimmunomodulation-in-glioblastoma-using-peptide-photosensitizer-conjugates\/","title":{"rendered":"Photoimmunomodulation in glioblastoma using peptide-photosensitizer conjugates"},"content":{"rendered":"<p><span style=\"font-weight: 400;\">Approximately 1,350 new cases of glioblastoma (GBM) are diagnosed per year in Spain. The standard treatment, consisting of radiotherapy and temozolomide, is very ineffective. Immunotherapy with antibodies against PD1\/L1 or CTLA4 has also not yielded good results.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Photodynamic therapy is a promising approach to treat GBM, but currently there are no ligands that can effectively transport photosensitizers to GBM. In this project we use guide peptides identified by us to transport photosensitizers to selected populations of interest within GBM.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">The objective is to generate immunogenic cell death, using conjugates of a specific peptide for the SNAP25 protein, a new therapeutic target that we have identified.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">This is combined with the reversal of immunosuppression by reprogramming anti-inflammatory macrophages\/microglia using Mactide-V. Our hypothesis is that by attacking GBM on these two fronts, a durable antitumor immunity will be activated.<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>This project aims to investigate new treatment modalities for glioblastoma, the brain tumor with the most unfavorable prognosis. It investigates a multi-pronged approach consisting of simultaneously attacking cancer cells through immunostimulatory photodynamic therapy and reprogramming tumor-associated macrophages\/microglia using peptide conjugates and drugs selective for these cells. <\/p>\n","protected":false},"featured_media":11073,"parent":0,"template":"","meta":{"_acf_changed":false},"tags":[173,187],"enfermedad":[171],"framework":[155],"linea-de-investigacion":[172,163],"class_list":["post-11072","proyecto","type-proyecto","status-publish","has-post-thumbnail","hentry","tag-medicinal-chemistry","tag-peptides","enfermedad-cancer","framework-aei-agencia-estatal-de-investigacion","linea-de-investigacion-treat","linea-de-investigacion-understand","entry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.7 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Photoimmunomodulation in glioblastoma using peptide-photosensitizer conjugates | IQAC - Institut de Qu\u00edmica Avan\u00e7ada de Catalunya - CSIC<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.iqac.csic.es\/en\/project\/photoimmunomodulation-in-glioblastoma-using-peptide-photosensitizer-conjugates\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Photoimmunomodulation in glioblastoma using peptide-photosensitizer conjugates | IQAC - Institut de Qu\u00edmica Avan\u00e7ada de Catalunya - CSIC\" \/>\n<meta property=\"og:description\" content=\"This project aims to investigate new treatment modalities for glioblastoma, the brain tumor with the most unfavorable prognosis. 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