{"id":11074,"date":"2026-07-07T12:40:32","date_gmt":"2026-07-07T10:40:32","guid":{"rendered":"https:\/\/www.iqac.csic.es\/proyecto\/modulating-receptor-biology-function-with-photocontrolled-molecular-tools-the-vitamin-d-receptor-as-a-model\/"},"modified":"2026-07-07T12:40:32","modified_gmt":"2026-07-07T10:40:32","slug":"modulating-receptor-biology-function-with-photocontrolled-molecular-tools-the-vitamin-d-receptor-as-a-model","status":"publish","type":"proyecto","link":"https:\/\/www.iqac.csic.es\/en\/project\/modulating-receptor-biology-function-with-photocontrolled-molecular-tools-the-vitamin-d-receptor-as-a-model\/","title":{"rendered":"Modulating Receptor Biology Function with Photocontrolled Molecular Tools: The Vitamin D Receptor as a Model"},"content":{"rendered":"<p>This project aims to use photoswitchable agonists of the vitamin D receptor (VDR), combined with cutting-edge techniques such as time-resolved protein crystallography and hydrogen-deuterium exchange (HDX) photopharmacology, to establish causal links between time-dependent molecular mechanisms and the transcriptional regulation of genes associated with beneficial and adverse physiological effects of VDR.<\/p>\n<p>This approach will enable precise spatial and temporal control of VDR activity, providing mechanistic insights into how activation dynamics influence gene regulation across different cell types. 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