{"id":11112,"date":"2026-07-07T11:58:45","date_gmt":"2026-07-07T09:58:45","guid":{"rendered":"https:\/\/www.iqac.csic.es\/proyecto\/hydrolipidic-gel-as-a-substitute-material-for-the-acid-mantle-in-skin-pathologies\/"},"modified":"2026-07-07T11:58:45","modified_gmt":"2026-07-07T09:58:45","slug":"hydrolipidic-gel-as-a-substitute-material-for-the-acid-mantle-in-skin-pathologies","status":"publish","type":"proyecto","link":"https:\/\/www.iqac.csic.es\/en\/project\/hydrolipidic-gel-as-a-substitute-material-for-the-acid-mantle-in-skin-pathologies\/","title":{"rendered":"Hydrolipidic Gel as a Substitute Material for the Acid Mantle in Skin Pathologies"},"content":{"rendered":"<p>The skin acts as a protective barrier thanks, among other elements, to the acid mantle, a thin hydrolipidic film located in the stratum corneum that prevents dehydration, protects against infections, and maintains skin balance. In diseases such as atopic dermatitis or ichthyosis, this mantle is altered or absent, contributing to the development and chronification of the disease. Currently, there are no materials capable of replacing it, and available treatments are mainly symptomatic and not very effective. This project proposes to develop a biomimetic material based on a nanostructured hydrolipidic gel capable of imitating the acid mantle and restoring the functionality of diseased skin. The project will combine physicochemical and biomedical studies, including material characterization, lipid analysis of healthy and diseased skin, and in vitro and in vivo evaluation of its therapeutic efficacy.    <\/p>\n","protected":false},"excerpt":{"rendered":"<p>This project develops a biomimetic gel that mimics the skin&#8217;s acid mantle to restore barrier function in chronic diseases such as dermatitis or ichthyosis.<\/p>\n","protected":false},"featured_media":11113,"parent":0,"template":"","meta":{"_acf_changed":false},"tags":[190,173],"enfermedad":[206],"framework":[131],"linea-de-investigacion":[172,163],"class_list":["post-11112","proyecto","type-proyecto","status-publish","has-post-thumbnail","hentry","tag-lipids","tag-medicinal-chemistry","enfermedad-dermatological","framework-plan-estatal-peicti","linea-de-investigacion-treat","linea-de-investigacion-understand","entry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.7 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Hydrolipidic Gel as a Substitute Material for the Acid Mantle in Skin Pathologies | IQAC - 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