{"id":11204,"date":"2026-07-06T14:11:19","date_gmt":"2026-07-06T12:11:19","guid":{"rendered":"https:\/\/www.iqac.csic.es\/proyecto\/chemical-biology-approaches-to-the-synthesis-and-study-of-lipid-modified-proteins\/"},"modified":"2026-07-06T14:11:19","modified_gmt":"2026-07-06T12:11:19","slug":"chemical-biology-approaches-to-the-synthesis-and-study-of-lipid-modified-proteins","status":"publish","type":"proyecto","link":"https:\/\/www.iqac.csic.es\/en\/project\/chemical-biology-approaches-to-the-synthesis-and-study-of-lipid-modified-proteins\/","title":{"rendered":"Chemical biology approaches to the synthesis and study of lipid-modified proteins"},"content":{"rendered":"

Lipids are essential cellular components involved in energy storage, membrane organization, cell signalling and the regulation of protein function. Proteins can be post-translationally modified through the covalent attachment of lipids, which confer hydrophobic character, promote membrane association and can modulate protein\u2013protein interactions. <\/p>\n

The most common lipidations include S-prenylation of cysteines, myristoylation of glycines, S-acylation and the incorporation of GPI units. Other relevant modifications are the cholesterylation of Hedgehog proteins and the conjugation of phosphatidylethanolamine to GABARAP and LC3. <\/p>\n

This project will study lipidated proteins by identifying and quantifying the lipids attached to them and developing chemical synthesis or semisynthesis methods, with the aim of gaining a better understanding of their function.<\/p>\n","protected":false},"excerpt":{"rendered":"

Proteins are modified through the covalent attachment of a wide variety of lipids, and these modifications regulate their localisation, interactions and function. This project aims to identify and quantify protein-bound lipids and generate modified proteins using chemical synthesis or semisynthesis methods. <\/p>\n","protected":false},"featured_media":11206,"parent":0,"template":"","meta":{"_acf_changed":false},"tags":[173,220,202],"enfermedad":[],"framework":[131],"linea-de-investigacion":[172,163],"class_list":["post-11204","proyecto","type-proyecto","status-publish","has-post-thumbnail","hentry","tag-medicinal-chemistry","tag-organic-synthesis","tag-proteins","framework-plan-estatal-peicti","linea-de-investigacion-treat","linea-de-investigacion-understand","entry"],"acf":[],"yoast_head":"\nChemical biology approaches to the synthesis and study of lipid-modified proteins | IQAC - Institut de Qu\u00edmica Avan\u00e7ada de Catalunya - CSIC<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.iqac.csic.es\/proyecto\/aproximaciones-de-biologia-quimica-para-la-sintesis-y-el-estudio-de-proteinas-modificadas-con-lipidos\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Chemical biology approaches to the synthesis and study of lipid-modified proteins | IQAC - Institut de Qu\u00edmica Avan\u00e7ada de Catalunya - CSIC\" \/>\n<meta property=\"og:description\" content=\"Proteins are modified through the covalent attachment of a wide variety of lipids, and these modifications regulate their localisation, interactions and function. 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