TENSIOACTIVOS Y LIQUIDOS IONICOS BIOCOMPATIBLES
Jefe de grupo: Aurora Pinazo
Actualmente, la industria química se enfrenta a uno de los retos más importantes de su historia. Las actuales directrices mundiales en cuanto a la calidad de vida, exigen el uso de procesos integrados de producción sostenible que, para generar productos de alto valor añadido, utilicen de manera racional las materias primas naturales renovables. La principal reacción a esto es el aumento en la investigación sobre cómo se pueden utilizar los recursos renovables en la síntesis de nuevos compuestos biocompatibles.
Dado que se sabe que los compuestos que presentan actividad superficial pueden afectar negativamente al medio acuático, hay una clara tendencia a emplear materias primas renovables no tóxicas como materiales de partida para la síntesis de compuestos biocompatibles no contaminantes. En este contexto, nuestro grupo lleva a cabo una investigación exhaustiva de nuevos tensioactivos y líquidos iónicos derivados de fuentes naturales renovables, tales como aminoácidos y aceites naturales. Nuestro objetivo es desarrollar tensioactivos y líquidos iónicos biocompatibles y biodegradables. Los tensioactivos y los líquidos iónicos con estas propiedades cubrirían, en parte, las necesidades de una serie de industrias tales como la industria de la alimentación, la cosmética y la farmacéutica.
LÍNEAS DE INVESTIGACIÓN
- Síntesis de nuevos tensioactivos y líquidos iónicos biocompatibles derivados de aminoácidos
- Estudio de su adsorción en interfaces y de sus propiedades de agregación.
- Estudio de las interacciones con membranas biológicas.
- Estudio de su actividad antimicrobiana, toxicidad y biodegradación.
Liquid crystals of biocompatible amino acid based surfactants and ionic liquids
Antimicrobial effect of biocompatible amino acid based surfactants on E. coli bacteria
Personal científico
Aurora Pinazo
Científico Titular
aurora.pinazo@iqac.csic.es
Mª Teresa García
Científico Titular
teresa.garcia@iqac.csic.es
Lourdes Pérez
Científico Titular
lourdes.perez@iqac.csic.es
Personal de laboratorio
Juan José González
Ayudante investigación
juanjose.gonzalez@iqac.csic.es
Isabel Ribosa
Investigador contratado
isabel.ribosa@iqac.csic.es
Anderson Ramos
Investigador predoctoral
anderson.ramos@iqac.csic.es
- Arginine-phenylalanine and arginine-tryptophan-based surfactants as new biocompatible antifungal agents and their synergistic effect with Amphotericin B against fluconazole-resistant Candida strains-
Serpa Sampaio Moreno, L., Nobre Junior, H.V., Ramos da Silva, A., Aires do Nascimento, F.B.S., Rocha da Silva, C., de Andrade Neto, J.B., Cavalcanti, B.C., Odorico de Moraes, M., Pinazo, A., Pérez, L.
Colloids and Surfaces B: Biointerfaces, 207, art. no. 112017, 2021
- Green cationic arginine surfactants: Influence of the polar head cationic character on the self-aggregation and biological properties-
Pérez, L., Pons, R., Oliveira de Sousa, F.F., Morán, M.D.C., Ramos da Silva, A., Pinazo, A
Journal of Molecular Liquids, 339, art. no. 116819, . 2021
- Antifungal activity of amino-alcohols based cationic surfactants and in silico, homology modeling, docking and molecular dynamics studies against lanosterol 14-α-demethylase enzyme-
Hafidi, Z., El achouri, M., O.Sousa, F.F., Pérez, L.
Journal of Biomolecular Structure and Dynamics, 2021
- Interaction of cationic surfactants with DPPC membranes: effect of a novel N α-benzoylated arginine-based compound-
Hermet, M., Elisa Fait, M., Vazquez, R.F., Mate, S., Daza Millone, M.A., Elena Vela, M., García, M.T., Morcelle, S.R., Bakas, L.
Amino Acids, 2021
- Development of anacardic acid-loaded zein nanoparticles: Physical chemical characterization, stability and antimicrobial improvement-
Araujo, J.T.C.D., Martin-Pastor, M., Pérez, L., Pinazo, A., Sousa, F.F.O.D.
Journal of Molecular Liquids, 332, art. no. 115808, 2021
- Aggregation behavior, antibacterial activity and biocompatibility of catanionic assemblies based on amino acid‐derived surfactants-
Pérez, L., Pinazo, A., Morán, M.C., Pons, R.
International Journal of Molecular Sciences, 21 (23), art. no. 8912, pp. 1-23. 2020
- Catanionic mixtures of surface-active ionic liquids and N-lauroyl sarcosinate: Surface adsorption, aggregation behavior and microbial toxicity-
Garcia, M.T., Ribosa, I., Gonzalez, J.J., Comelles, F.
Journal of Molecular Liquids, 318, art. no. 114040, 2020
- Antifungal and antiprotozoal green amino acid-based rhamnolipids: Mode of action, antibiofilm efficiency and selective activity against resistant Candida spp. strains and Acanthamoeba castellanii-
da Silva, A., Nobre, H., Sampaio, L., Nascimento, B.D., da Silva, C., de Andrade Neto, J.B., Manresa, Á., Pinazo, A., Cavalcanti, B., de Moraes, M.O., Ruiz-Trillo, I., Antó, M., Morán, C., Pérez, L.
Colloids and Surfaces B: Biointerfaces, 193, art. no. 111148, 2020
- Biocompatible catanionic vesicles from arginine-based surfactants: A new strategy to tune the antimicrobial activity and cytotoxicity of vesicular systems-
Pinazo, A., Pons, R., Marqués, A., Farfan, M., da Silva, A., Perez, L.
Pharmaceutics, 12 (9), art. no. 857, pp. 1-24. 2020
- Protein expression knockdown in cancer cells induced by a gemini cationic lipid nanovector with histidine-based polar heads-
Sánchez-Arribas, N., Martínez-Negro, M., Villar, E.M., Pérez, L., Barcina, J.O., Aicart, E., Taboada, P., Guerrero-Martínez, A., Junquera, E.
Pharmaceutics, 12 (9), art. no. 791, pp. 1-22. 2020
- Biocompatible Nanovector of siRNA Consisting of Arginine-Based Cationic Lipid for Gene Knockdown in Cancer Cells-
Sánchez-Arribas, N., Martínez-Negro, M., Villar, E.M., Pérez, L., Aicart, E., Taboada, P., Guerrero-Martínez, A., Junquera, E.
ACS applied materials & interfaces, 12 (31), pp. 34536-34547. 2020
- Surface activity, self-aggregation and antimicrobial activity of catanionicmixtures of surface active imidazolium- or pyridinium-based ionicliquids and sodium bis(2-ethylhexyl) sulfosuccionate-
M. Teresa Garcia, Isabel Ribosa, Juan José González, Francesc Comelles
Journal of Molecular Liquids 303, 2020, 112637
- Rhamnolipids functionalized with basic amino acids: Synthesis, aggregation behavior, antibacterial activity and biodegradation studies-
Ramos da Silva, A., Manresa, M.Á., Pinazo, A., García, M.T., Pérez, L.
Colloids and Surfaces B: Biointerfaces, 181, pp. 234-243. 2019
- Gemini histidine based surfactants: Characterization; surface properties and biological activity-
Pinazo, A., Pons, R., Bustelo, M., Manresa, M.Á., Morán, C., Raluy, M., Pérez, L.
Journal of Molecular Liquids, 289, art. no. 111156, 2019
- Synthesis, self-assembly, bacterial and fungal toxicity, and preliminary biodegradation studies of a series of L-phenylalanine-derived surface-active ionic liquids-
Illia V. Kapitanov, Andrew Jordan, Yevgen Karpichev, Marcel Spulak, Lourdes Perez, Andrew Kellett, Klaus Kümmerer and Nicholas Gathergood
Green Chem. 2019
- Biodegradability and aquatic toxicity of new cleavable betainate cationic oligomeric surfactants-
M. Teresa Garcia, Isabel Ribosa, Iwona Kowalczyk, Marta Pakiet and Bogumil Brycki
Journal of Hazardous Materials 371 (2019) 108–114
- Green Catanionic Gemini Surfactant–Lichenysin Mixture: Improved Surface, Antimicrobial, and Physiological Properties.-
Ruiz A., A. Pinazo, L. Pérez, A. Manresa, A. Marquez
ACS Appl. Mater. Interfaces, 2017, 9, 22121-22131.
- Monocatenary histidine-based surfactants: Role of the alkyl chain length in antimicrobial activity and their selectivity over red blood cells-
Bustelo, M; Pinazo, A.; Manresa, M.A.; Vinardell, M.P.; Pérez, L.
Colloids Surf A, 2017, 532, 501-509.
- Pharmaceutical versatility of cationic niosomes derived from amino acid-based surfactants: Skin penetration behavior and controlled drug release.-
Muzzalupo, L. Pérez, A. Pinazo, L. Tavano
Int J Pharm., 2017, 529, 245-252.
- Protein-repellent and antimicrobial nanoparticle coatings from hyaluronic acid and a lysine-derived biocompatible surfactant-
Bračič, M., Fras-Zemljič, L.,Pérez, L.,Kogej, K.,Stana-Kleinschek, K.,Kargl, R., Mohan, T.
J Mater Chem B. 2017, 5, 3888-3897.
- Hydrophilicity and flexibility of the spacer as critical parameters on the aggregation behavior of long alkyl chain cationic gemini surfactants in aqueous solution.-
M.T. Garcia; O. Kaczerewska; I. Ribosa; B. Brycki; P. Materna; M. Drgas.
J Molec Liquids. 2017, .230, 453 - 460.
- Micellization and Antimicrobial Properties of Surface-Active Ionic Liquids Containing Cleavable Carbonate Linkages-
M.Teresa Garcia; Isabel Ribosa; Lourdes Perez; Angeles Manresa; Francesc Comelles..
Langmuir. 2017, 33 -26, 6511 - 6520.
- New cationic vesicles prepared with double chain surfactants from arginine: Role of the hydrophobic group on the antimicrobial activity and cytotoxicity.-
Pinazo, A; Petrizelli, V; Bustelo, M; Pons, R; Vinardell, M P; Mitjans, M; Manresa, A; Perez, L
Colloids Surf B Biointerfaces, 2016, 141, 19-27
- Amino acid-based surfactants: New antimicrobial agents-
Pinazo, A.; Manresa, M. A.; Marques, A. M.; Pérez, L.
Adv Colloid Interface Sci. 2016, 228, 17-39
- Biodegradability and aquatic toxicity of quaternary ammonium-based gemini surfactants: Effect of the spacer on their ecological properties.-
M.T. Garcia; O. Kaczerewska; I. Ribosa; B. Brycki; P. Materna; M. Drgas.
Chemosphere. 2016, 154, 155 - 160.
- Cationic vesicles based on biocompatible diacyl glycerol-arginine surfactants: Physicochemical properties, antimicrobial activity, encapsulation efficiency and drug release-
LTavano, A. Pinazo, M. Abo-Riya, M.R. Infante, M.A, Manresa, Pérez L.
Colloids Surf B Biointerfaces. 2014,120, 160-167.
- Self-assembly and antimicrobial activity of long-chain amide-functionalized ionic liquids in aqueous solution.-
M.T. Garcia; I. Ribosa; L. Perez; A. Manresa; F. Comelles.
Colloids Surf B Biointerfaces. 2014, 123, 318 - 325.
- Amino Acid Based Surfactants: An Overview-
Pérez, A. Pinazo, R. Pons, M.R. Infante
Adv Colloid Interface Sci. 2014, 205, 134-135.
- Role of aggregate size in the hemolytic and antimicrobial activity of colloidal solutions based on single and gemini surfactants from arginine-
Tavano, M.R. Infante, M. Abo Riya, A. Pinazo, M.P. Vinardell, M. Mitjans, M.A. Manresa, L. Perez
Soft Matter, 2013, 9, 306-319.
- Mixed Monolayer of DPPC and Lysine-Based Cationic Surfactants: An Investigation into the Antimicrobial Activity-
Colomer, L. Pérez, R. Pons, M.R. Infante, D. Perez-Clos, A. Manresa, M.J. Espuny, A. Pinazo
Langmuir, 2013, 29, 7912-7921.
- A new generation of aprotic yet Brønsted acidic imidazolium salts: effect of ester/amide groups in the C-2, C-4 and C-5 on antimicrobial toxicity and biodegradation.-
R.G. Gore, L. Myles, M. Spulak, I. Beadham, M.T. Garcia, S.J. Connon, N. Gathergood.
Green Chemistry. 2013, 15, 2747 - 2760.
- Aggregation behavior and antimicrobial activity of ester-functionalized imidazolium- and pyrdinium based ionic liquids in aqueous solution.-
M.T.Garcia , I. Ribosa, L. Perez, A. Manresa, F. Comelles.
Langmuir. 2013, 29, 2536 -2545.
- Antimicrobial toxicity studies of ionic liquids leading to a "hit" MRSA selective antibacterial imidazolium salt.-
Coleman; M. Spulak; M.T. Garcia; N. Gathergood.
Green Chemistry. 2012, 14, 1350 - 1356.
- Interaction of Nonionic Surfactants and Hydrophilic Ionic Liquids in Aqueous Solutions: Can Short Ionic Liquids Be More than a Solvent?.-
Comelles; I. Ribosa; J.J. González; M.T. Garcia.
Langmuir. 2012, 28, 14522 - 14530.
- Self-aggregation and antimicrobial activity of imidazolium and pyridinium based ionic liquids in aqueous solution.-
Cornellas, L. Pérez, F. Comelles, I. Ribosa, A. Manresa; M.T. García.
J Colloid Interface Sci. 2011, 355, 164 - 171.
- Adsorption of polyphenols in wastewater by organo-bentonites-
A.Marsal, E. Bautista, I. Ribosa, R. Pons, M.T. García
Applied Clay Science 44 (2009) 151 – 155
- Cationic gemini surfactants containing an O-substituted spacer and hydroxyethyl moiety in the polar heads: Self-assembly, biodegradability and aquatic toxicity-
O.Kaczerewska; B. Brycki; I. Ribosa; F. Comelles; M.T. Garcia.
J Industrial Engineer Chem. 2018, 59, 141-148
