KNOWLEDGE TRANSFER UNIT
The method here presented allows easy monitoring of the ACDase activity (ACDase) in lysosomal intact cells by using a specific substrate of ACDase. ACDase deficiency and storage of undegraded ceramides in lysosomes cause Farber disease. Currently, measurement of ACDase can be performed by genetic testing or by biochemical analyses, which require long and laborious analytical methods involving radiolabeling, being only available to highly specialized laboratories.
Precise and early diagnosis of cystinuria disease, through urine testing. It is based on dynamic molecular networks to produce a measurable signal when some substances are linked to a specific molecule.
Immunochemical method for diagnosis of infections produced by Pseudomonas aeruginosa, one of the leading causes of infections in hospitalised and immune compromised patients. The immunoassay is fast and efficient, with low LOD and adaptable to point-of care devices.
Immunochemical method for diagnosis of infections produced by Staphylococcus aureus, an important cause of community and hospital acquired infections. The immunoassay is specific, sensitive and adaptable to point-of care devices.
Monoclonal antibodies able to determine risk of cardiovascular disease based on the quantification of lipoprotein (a), taking into consideration the variability on its kringle IV type 2 domain (KIV-2) repeats.
IIQAC_019 Test for early diagnosis of rheumatoid arthritis based on chimeric fibrin and filaggrin peptides
An ELISA using chimeric citrullinated peptides derived from a-fibrin and filaggrin chains has been developed for early diagnosis of rheumatoid arthritis. Tested in sera from 900 patients, it shows improved sensitivity and prognostic value, as it is able to identify patients with aggressive disease and works where other commercial tests failed.
IMMUNOLOGY / ADJUVANTS
Novel non-glycosidic analogues of alpha-galactosylceramide (α-GalCer) that induce proliferation of natural killer T (NKT) cells, involved in immune responses. These compounds are versatile modulators of cytokine production and induce a strong and efficient immunitary response. They have potential as drugs in single therapy or as adjuvants for vaccine, antibody or cell immunotherapies in cancer, infections or autoimmune diseases.
Treatment of non-alcoholic fatty liver diseases, in particular steatohepatitis, based on the use of a family of fatty acid amides with phenylalkylamines related compounds (OLHHA), which induces a reduction of liver damage.
IQAC_007 Bicosomes: bicelles encapsulated in liposomes and their application in diluted systems. LICENSED
A new sort of liposomes containing bicelles, called bicosomes, in such a way that bicelle morphology is preserved in diluted environments. Bicosomes allow encapsulation and administration of drugs, dyes or pigments acting as carrier for substances of cosmetic, dermatological and pharmaceutical interest in diluted water solutions and as permeability enhancers of biological membranes.
Aldolase able to catalyze C-C bond formation at MOLAR aldehyde concentrations. With broad substrate acceptance (aldehydes and keto-acids), many functionalized products are synthesized at high productivities for industrial production. Application to L-homoserine production
FSA enzyme variants with improved chemo- and enantioselectivity in aldol carboligation reactions (single C-C bond formation) rendering (poly)hydroxylate products of industrial interest, such as Roche ester or of 4-chloro-3-hydroxybutanal, under environmentally friendly conditions.
Synthetic Human Skin model useful to study the capacity of permeation and percutaneous absorption of cosmetic and pharmaceutical actives.
New device that allows the simultaneous multiple analyte analysis in a fluid by biosensors dipped into a plurality of microchambers, in which such fluid is supplied, with identical flow, in independently controlled functional time periods. This technology can be applied to the on-site quantification of pollutants and other analytes, especially for environmental control in sea or river waters.
Three-dimensional impedimetric biosensor that allows a direct detection of analytes from a biological sample of human, veterinarian or environmental origin. The biosensor increases significantly the sensitivity to changes in impedance deriving from biochemical processes in comparison with conventional planar devices (2 orders of magnitude in signal/noise relation).
IQAC_ 064.Multicomponent particles for genetic modification of eukaryotic cells and selection of modified cells
Method based on multicomponent particles to enhance transfection of non viral genetic material in eukaryotic cells.
Haptens to generate antibodies to fluoroquinolone-based antibiotics for determining their residues in food. The immunoassay is fast and efficient, has detection limits of 0.025-6 ppb depending on the fluoroquinolone, matrix and animal species and detects fluoroquinolones undetectable with other methods.
Institut de Química Avançada de Catalunya
c/ Jordi Girona 18-26
08034 Barcelona - Spain
Ph: +34 93 400 61 00
Fax: +34 93 204 59 04