Jordi Bujons earned his PhD in Organic Chemistry from the University of Barcelona in 1994. He subsequently moved to the University of British Columbia (Vancouver, Canada), where he completed a three-year postdoctoral stay in the group of Prof. A. G. Mauk, working on the generation and characterization of cytochrome c peroxidase enzyme mutants.

In 1998, he returned to the Institute for Advanced Chemistry of Catalonia, where he established himself as a CSIC Tenured Scientist in 2001, later joining the Biotransformations and Bioactive Compounds group (2006).

His research focuses on the computational design and mechanistic study of enzymes as biocatalysts in organic synthesis, with a particular emphasis on the stereoselective formation of C–X bonds. This work has enabled the rational optimization of the active sites of various enzymes, especially aldolases, with the aim of expanding substrate scope as well as improving catalytic efficiency and stereoselectivity.

Thanks to his expertise in molecular modeling, he has also contributed to a wide variety of projects in biological and medicinal chemistry, including the design of new apoptosis regulators, the study of GABAA receptor modulators, the modeling of supramolecular systems, and the development of PROTAC molecules targeting proteins of interest.