In recent decades, bacterial infections caused by multidrug-resistant pathogens have become a global problem. This situation is aggravated by the ability of microorganisms to form biofilms, present in 80% of human infections, which hinder the action of antimicrobials. Current strategies, based on compounds such as quaternary ammonium, metals or antibiotics, present toxicity and environmental impact problems. This project proposes the development of environmentally friendly antimicrobial materials and formulations based on biodegradable compounds, such as biopolymers, naturally derived ionic liquids and surfactants derived from amino acids. Antimicrobial polymers will be designed to prevent colonization, as well as nanoparticles and adjuvant systems to eliminate biofilms. Their properties, efficacy, cytotoxicity and environmental impact will be evaluated. The results will contribute to the development of safer and more sustainable antimicrobial strategies.