Speaker: Carme Fàbrega, from Nucleic Acids Chemistry group
Title: DNA nanostructures for the delivery of therapeutic drugs
CSIC Conecta link: https://conectaha.csic.es/b/mar-1ke-bvx-r7d
Abstract:
DNA is an attractive molecule for the fabrication of nanostructures due to its explicit characteristics such as specific recognition between complementary nucleotides, predictability and rigidity. The DNA origami development was one of the more interesting discoveries in the DNA nanotechnology field permitting the formation of around 100 nm nanostructures with exquisite control of the size and shape. My line of research is focused on developing new prototype of nanomedicines base on DNA origami technology. The concept is based on the use of precisely folded DNA nanostructures multi-functionalized at specific locations with a variety of antiproliferative and gene silencing drugs and molecules for enhancing cellular uptake. The therapeutic agents will be engineered in the nanostructure and expected to be liberated as the structure is internalized. Special attention will be paid to creating different DNA nanostructures as multifunctional delivery systems.