The Percutaneous Absorption group deals with the knowledge and quantitation of the skin absorption of a given compound topically applied. Using an in vitro methodology officially adopted by the OECD (2004), the distribution of a chemical in the different skin compartments (stratum corneum, epidermis and dermis) can be detected and quantified.
A percutaneous absorption protocol depends on a number of experimental factors such as exposure time, presence or absence of occlusion, formulation type and frequency of use. Dermal absorption is evaluated on human skin, porcine skin, membranes or cosmeto-textiles.
Some tests are:
The Skin Efficacy group deals with the experimental design, evaluation and objective diagnostic of the skin efficacy and tolerance of cosmetic and dermatologic formulations topically applied by the use of non-invasive biophysical techniques. Evaluation and diagnosis of other keratinized tissues such as human nails are also evaluated.
In vivo skin efficacy
Studies are conducted with Caucasian panellists with skin phototype III-IV in a conditioned room at 22ºC and 50% RH under dermatological control. Some of these protocols are also used on nails.
In vitro skin efficacy
The Hair Efficacy group deals with the experimental design and evaluation of the in vitro efficacy of cosmetic formulations applied to the hair.
Institut de Química Avançada de Catalunya
c/ Jordi Girona 18-26
08034 Barcelona - Spain
Ph: +34 93 400 61 00
Fax: +34 93 204 59 04
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