Pablo Scodeller

Tenured Scientist

IQAC

Department

Biological Chemistry

Research group

Chemical Biology (CHEMBIO)

Contact

Email

pablo.scodeller@iqac.csic.es

Phone

934 00 61 00

Extension

437818

Profiles

ORCID

0000-0003- 0745-2467

LinkedIn

Pablo Scodeller

Pablo Scodeller

Tenured Scientist

Scodeller earned his degree in Biomedical Engineering from the University of Mendoza, Argentina and his PhD in Chemistry from the University of Buenos Aires in 2011. Following a two-year postdoctoral fellowship in materials science in CNEA (Argentina), he joined the laboratory of Dr. Erkki Ruoslahti (recipient of the 2022 Lasker Award) in La Jolla, USA, in 2013 to complete a two-year postdoctoral fellowship in the field of the tumor microenvironment.

In 2015, he moved to the University of Tartu, Estonia, to conduct postdoctoral research in the laboratory of Dr. Tambet Teesalu, a pioneer in the field of tumor-penetrating peptides.

In 2017, he was awarded a Starting Grant from the Estonian Research Council, and in 2018 was promoted to Associate Professor at the University of Tartu. In 2021 he was awarded a Ramón y Cajal contract and in 2025 he obtained tenure as a CSIC researcher.

His research focuses on identification of new targeting peptides and therapeutic targets in disease, precision drug delivery to solid tumors (breast cancer, glioma, neuroendocrine carcinomas), and new immunotherapies based on tumor macrophage reprogramming.

Using in vivo peptide phage display, Scodeller has co-identified targeting peptides for cancer, brain injuries, and Alzheimer´s disease, which have been used by over 40 independent research groups for targeted drug delivery and have led to 5 patents, 4 of which are licensed to companies. He has obtained 7 research grants (totaling ca. 1M€) as a principal investigator and supervised 3 doctoral thesis and 5 masters thesis.

Personal website

This project aims to drive the preclinical development of a patented peptide-drug conjugate we have developed, called "Mactide-V", for the treatment of breast cancer. Mactide-V represents a new immunotherapy that acts through the selective reprogramming of tumor-associated macrophages. In murine models of metastatic triple-negative breast cancer, Mactide-V treatment prevented metastases and outperformed the efficacy of anti-PD-1 (an immune checkpoint blocker used in clinical practice for this type of cancer).
This project aims to investigate new treatment modalities for glioblastoma, the brain tumor with the most unfavorable prognosis. It investigates a multi-pronged approach consisting of simultaneously attacking cancer cells through immunostimulatory photodynamic therapy and reprogramming tumor-associated macrophages/microglia using peptide conjugates and drugs selective for these cells.